Scheen, André, Buxton, O M, Jison, M, Van Reeth, O, Leproult, R, L'Hermite-Baleriaux, M, ...
To study the effects of time of day on neuroendocrine and metabolic responses to exercise, body temperature, plasma glucose, insulin secretion rates (ISR), and plasma cortisol, growth hormone (GH)...
Consistent variations in glucose regulation across the 24-hour cycle are present in normal subjects. These diurnal variations are altered in various states of impaired glucose tolerance (aging,...
Relationships between sleep quality and glucose regulation in normal humans. (1996)
Scheen, André, Byrne, M M, Plat, L, Leproult, R, Van Cauter, E
To define the effects of sleep on glucose regulation, we analyzed plasma glucose levels, insulin secretion rates (ISR), and plasma growth hormone and cortisol levels in normal subjects receiving a...
Alterations in the ultradian oscillations of insulin secretion and plasma glucose in aging. (1996)
Scheen, André, Sturis, J, Polonsky, K S, Van Cauter, E
Normal insulin secretion includes oscillations with a period length of 80-150 min which are tightly coupled to glucose oscillations of similar period. To determine whether normal aging is associated...
Sturis, J, Scheen, André, Leproult, R, Polonsky, K S, Van Cauter, E
Under basal and stimulated conditions, normal insulin secretion oscillates with periods in the ultradian 100-150-min range. To test the hypothesis that oscillatory insulin delivery is more efficient...
O'Meara, N M, Sturis, J, Van Cauter, E, Polonsky, K S
Normal subjects demonstrate the presence of ultradian oscillations (period 80-150 min) in insulin secretion rate (ISR) tightly coupled to glucose oscillations of similar period. These oscillations...
Entrainment of pulsatile insulin secretion by oscillatory glucose infusion.
Sturis, J, Van Cauter, E, Blackman, J D, Polonsky, K S
Ultradian "oscillations" or "pulses" of insulin secretion with periods around 120 min occur in man. It is not known whether glucose plays an active role in generating these oscillations, or if an...
Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep.
Van Cauter, E, Blackman, J D, Roland, D, Spire, J P, Refetoff, S, Polonsky, K S
To define the roles of circadian rhythmicity (intrinsic effects of time of day independent of the sleep or wake condition) and sleep (intrinsic effects of the sleep condition, irrespective of the...
Sturis, J, Scheen, A J, Leproult, R, Polonsky, K S, Van Cauter, E
Under basal and stimulated conditions, normal insulin secretion oscillates with periods in the ultradian 100-150-min range. To test the hypothesis that oscillatory insulin delivery is more efficient...
Quantitative study of insulin secretion and clearance in normal and obese subjects.
Polonsky, K S, Given, B D, Hirsch, L, Shapiro, E T, Tillil, H, Beebe, C, ...
The secretion and hepatic extraction of insulin were compared in 14 normal volunteers and 15 obese subjects using a previously validated mathematical model of insulin secretion and rate constants for...
Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects.
Polonsky, K S, Given, B D, Van Cauter, E
The pattern of endogenous insulin secretion over a 24-h period, which included three mixed meals, was evaluated in 14 normal volunteers and 15 obese subjects. Insulin secretory rates were calculated...
Van Cauter, E, Hardman, J G, Dumont, J E
Mediators of hormone and neurotransmitter action may exert negative control on the accumulation of one another (adenosine 3':5'-cyclic monophosphate, or conversely). A model in which one agonist...
Van Cauter, E, Plat, L, Scharf, M B, Leproult, R, Cespedes, S, L'Hermite-Balériaux, M, ...
The aim of this study was to investigate, in normal young men, whether gamma-hydroxybutyrate (GHB), a reliable stimulant of slow-wave (SW) sleep in normal subjects, would simultaneously enhance sleep...
O'Meara, N M, Sturis, J, Van Cauter, E, Polonsky, K S
Normal subjects demonstrate the presence of ultradian oscillations (period 80-150 min) in insulin secretion rate (ISR) tightly coupled to glucose oscillations of similar period. These oscillations...
Entrainment of pulsatile insulin secretion by oscillatory glucose infusion.
Sturis, J, Van Cauter, E, Blackman, J D, Polonsky, K S
Ultradian "oscillations" or "pulses" of insulin secretion with periods around 120 min occur in man. It is not known whether glucose plays an active role in generating these oscillations, or if an...
Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep.
Van Cauter, E, Blackman, J D, Roland, D, Spire, J P, Refetoff, S, Polonsky, K S
To define the roles of circadian rhythmicity (intrinsic effects of time of day independent of the sleep or wake condition) and sleep (intrinsic effects of the sleep condition, irrespective of the...
Sturis, J, Scheen, A J, Leproult, R, Polonsky, K S, Van Cauter, E
Under basal and stimulated conditions, normal insulin secretion oscillates with periods in the ultradian 100-150-min range. To test the hypothesis that oscillatory insulin delivery is more efficient...
Quantitative study of insulin secretion and clearance in normal and obese subjects.
Polonsky, K S, Given, B D, Hirsch, L, Shapiro, E T, Tillil, H, Beebe, C, ...
The secretion and hepatic extraction of insulin were compared in 14 normal volunteers and 15 obese subjects using a previously validated mathematical model of insulin secretion and rate constants for...
Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects.
Polonsky, K S, Given, B D, Van Cauter, E
The pattern of endogenous insulin secretion over a 24-h period, which included three mixed meals, was evaluated in 14 normal volunteers and 15 obese subjects. Insulin secretory rates were calculated...
Van Cauter, E, Hardman, J G, Dumont, J E
Mediators of hormone and neurotransmitter action may exert negative control on the accumulation of one another (adenosine 3':5'-cyclic monophosphate, or conversely). A model in which one agonist...
Van Cauter, E, Plat, L, Scharf, M B, Leproult, R, Cespedes, S, L'Hermite-Balériaux, M, ...
The aim of this study was to investigate, in normal young men, whether gamma-hydroxybutyrate (GHB), a reliable stimulant of slow-wave (SW) sleep in normal subjects, would simultaneously enhance sleep...