Email Alerting, G Verbruggen, S De Backer, D Deforce, P Demetter, C Cuvelier, ...
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Kruithof, E, Baeten, D, De Rycke, L, Vandooren, B, Foell, D, Roth, J, ...
At present only few biological data are available to indicate whether psoriatic arthritis (PsA) is part of the spondyloarthropathy (SpA) concept, whether it is a separate disease entity or a...
Baeten, D, Kruithof, E, De Rycke, L, Boots, A, Mielants, H, Veys, E, ...
Considering the relation between synovial inflammation and global disease activity in rheumatoid arthritis (RA) and the distinct but heterogeneous histology of spondyloarthropathy (SpA) synovitis,...
Timing of DAS28 in infliximab therapy: reply (2005)
Durez, P., Corluy, L., Veys, E., De Clerck, L., Peretz, A., ...
Timing of DAS28 in infliximab therapy: reply (2005)
Durez, P., Corluy, L., Veys, E., De Clerck, L., Peretz, A., ...
De Keyser, Filip, Baeten, Dominique, Van Den Bosch, Filip, KRUITHOF, ELLI, VERBRUGGEN, G, Mielants, Herman, ...
De Keyser, F, Peeters, H, Marichal, D, Hoffman, I, ...
No abstract available.
Gu, J., Märker-Hermann, E., Baeten, D., Tsai, W. C., Gladman, D., Xiong, M., ...
Objectives. To identify genes which are more highly expressed in the peripheral blood mononuclear cells (PBMC) of patients with spondyloarthropathy (SpA), rheumatoid arthritis...
Inflammatory arthropathy and inflammatory bowel disease (1999)
De Vos, Martine, Mielants, Herman, De Keyser, Filip, CUVELIER, C, VEYS, E
Joosten, I., Veys, E., Elewaut, D., Bos, E., ...
Microgel immunoblotting of thymus and nuclear extracts by unidirectional diffusion (1989)
Verbruggen, G, Veys, E, Segers, J, Rabaey, M
A variant immunoblotting procedure is presented, starting from sodium dodecyl sulfate-containing ultra-thin microgels. The use of these gels allows efficient transfer of proteins to an immobilizing...
Elewaut, D., De Keyser, F., De Wever, N., Baeten, D., Van Damme, N., Verbruggen, G., ...
OBJECTIVES—(1)To analyse the in situ expression of adhesion molecules in rheumatoid nodules. (2) To compare the endothelial expression of adhesion molecules in synovial tissue and subcutaneous...
Vincent, C., De Keyser, F., Masson-Bessiere, C., Sebbag, M., Veys, E., Serre, G.
OBJECTIVE—Antiperinuclear factor (APF), "antikeratin antibodies" ("AKA"), and antibodies to human epidermis filaggrin (AFA), are highly specific serological markers of rheumatoid arthritis (RA),...
Non-Hodgkin's lymphoma presenting with spinal involvement
Vanneuville, B, Janssens, A, Lemmerling, M, De Vlam, K, Mielants, H, Veys, E
Anatomy and biochemistry of entheses
BENJAMIN, M., BOLLOW, M., BRAUN, J., BRANDT, J., BRAUN, J., BRAUN, J., ...
Baeten, D, Demetter, P, Cuvelier, C, Kruithof, E, Van Damme, N, ...
OBJECTIVES—To compare the macroscopic and microscopic characteristics of synovial tissue in rheumatoid arthritis (RA), spondyloarthropathy (SpA), and osteoarthritis (OA) after exclusion of possible...
Demetter, P, Baeten, D, De Keyser, F, De Vos, M, Van Damme, N, Verbruggen, G, ...
OBJECTIVE—Previously an upregulation of E-cadherin and its associated molecules α-catenin, β-catenin and plakoglobin has been demonstrated in clinically overt inflammatory bowel disease (IBD)....
Kruithof, E., Baeten, D., De Keyser, F., Mielants, H., Veys, E.
OBJECTIVE—To evaluate the efficacy and safety of a loading dose regimen of three intravenous infusions with infliximab in patients with active spondyloarthropathy. METHODS—A monocentre,...
Peene, I, Meheus, L, Veys, E, De Keyser, F
OBJECTIVE—To provide data on (a) the probability of detecting antinuclear antibodies (ANA) in a large and consecutive cohort of serum samples referred for ANA testing and (b) the probability of...
Van Damme, N, De Vos, M, Baeten, D, Demetter, P, Mielants, H, Verbruggen, G, ...
OBJECTIVE—To quantify the fraction of gut mucosal lymphocytes expressing the T helper type 1 (Th1) cytokines, interferon γ (IFNγ) and interleukin (IL)2, and the Th2 cytokines, IL4 and IL10, at...
Impaired Th1 cytokine production in spondyloarthropathy is restored by anti-TNFα
Baeten, D, Van Damme, N, Kruithof, E, De Vos, M, Mielants, H, ...
OBJECTIVES—To evaluate the effect of anti-TNFα on the Th1 and Th2 cytokines in patients with spondyloarthropathy (SpA). METHODS—Peripheral blood mononuclear cells (PBMC) were obtained from...
Almqvist, K, Wang, L, Wang, J, Baeten, D, Cornelissen, M, Verdonk, R, ...
OBJECTIVE—To produce tissue engineered cartilage by human articular chondrocytes in vitro for further use in in vivo manipulations for the treatment of cartilage defects. METHODS—Human...
Anti-Ro52 reactivity is an independent and additional serum marker in connective tissue disease
Peene, I, Meheus, L, De Keyser, S, Humbel, R, Veys, E, De Keyser, F
Methods: Over a two year period, 1727 consecutive antinuclear antibody (ANA) positive serum samples were analysed in parallel by double immunodiffusion with thymus/spleen nuclear extract and by line...
Peene, I, Meheus, L, Veys, E, De Keyser, F
Objective: To determine the diagnostic distribution in a consecutive anti-SSA and/or anti-SSB positive population.
Kruithof, E, Baeten, D, Herssens, A, De Keyser, F, Mielants, H, ...
Background: In a pilot study, the anti-tumour necrosis factor α monoclonal antibody, infliximab, induced a rapid and significant improvement in global, peripheral, and axial disease manifestations...
Hohler, T, Grossmann, S, Stradmann-Belling..., B, Kaluza, W, Reuss, E, De Vlam, K, ...
Objective: To investigate the potential association of tumour necrosis factor α (TNFα) microsatellite and promoter alleles with psoriatic arthritis (PsA).
Tenosynovitis with acute onset: unexpected giant cell tumour of the tendon sheath
Kruithof, E, Baeten, D, Dierckxsens, P, Veys, E, De Keyser, F
Hoffman, I, Demetter, P, Peeters, M, De Vos, M, Mielants, H, Veys, E, ...
Objectives: To investigate whether anti-Saccharomyces cerevisiae antibodies (ASCA), a marker for Crohn's disease (CD), are present in spondyloarthropathies (SpA) and in the subgroups ankylosing...
Baeten, D, Kruithof, E, Herssens, A, Mielants, H, ...
Background: Recent studies with infliximab indicate the therapeutic potential of tumour necrosis factor α blockade in spondyloarthropathy (SpA). Because defective host defence is implicated in the...
Wang, J, Elewaut, D, Hoffman, I, Veys, E, Verbruggen, G
Objective: To investigate the effects of physiological doses of hydrocortisone on synthesis and turnover of cell associated matrix (CAM) by human chondrocytes obtained from normal articular cartilage.
Case Number 29: Ochronosis: synovial histopathological characteristics
Kruithof, E, Baeten, D, Veys, E, De Keyser, F, Suykens, S, De Wilde, L, ...
Baeten, D, De Keyser, F, Veys, E, Theate, Y, Houssiau, F, Durez, P
Background: It has been suggested that the immunopathology of rheumatoid nodules parallels that of inflamed synovium in rheumatoid arthritis (RA).
Rihl, M, Baeten, D, Seta, N, Gu, J, De Keyser, F, Veys, E, ...
Objectives: To validate the use of cDNA based microarray on synovial biopsies by analysing the experimental variability due to amplification of RNA, reproducibility of the assay, heterogeneity of the...
Cuvelier, C, Mielants, H, De Vos, M, Veys, E, Roels, H
Major histocompatibility complex molecules act as non-specific receptors for antigenic proteins and present them to T-cells. Presented antigen together with class II molecules activates antigen...
Histopathology of intestinal inflammation related to reactive arthritis.
Cuvelier, C, Barbatis, C, Mielants, H, De Vos, M, Roels, H, Veys, E
This study has identified a group of patients with inflammatory chronic, or relapsing acute arthritis who even in the absence of gastrointestinal symptoms have histological evidence of ileocolitis....
Cuvelier, C, Mielants, H, De Vos, M, Veys, E, Roels, H
In 40 distal ileal and 40 colonic biopsies of arthritic patients mostly without gastrointestinal symptoms, but with histological evidence of acute or chronic inflammation of the gut, the number of...
Hoffman, I, Peene, I, Meheus, L, Huizinga, T, Cebecauer, L, Isenberg, D, ...
Methods: A consecutive cohort of 289 patients with SLE was included; 235 fulfilled ACR criteria for SLE and were further analysed. ANA profiles were determined by line immunoassay and by indirect...
Outcomes of a multicentre randomised clinical trial of etanercept to treat ankylosing spondylitis
Calin, A, Dijkmans, B, Emery, P, Hakala, M, Kalden, J, Leirisalo-Repo, M, ...
Objective: A double blind, randomised, placebo controlled study to evaluate the safety and efficacy of etanercept to treat adult patients with ankylosing spondylitis (AS).
De Rycke, L, Peene, I, Hoffman, I, Kruithof, E, Union, A, Meheus, L, ...
Background: Autoantibodies such as rheumatoid factor (RF) and anticitrullinated protein antibodies can be detected in rheumatoid arthritis (RA) sera.
Demetter, P, De Vos, M, Van Huysse, J A, Baeten, D, Ferdinande, L, Peeters, H, ...
Objective: To investigate macrophages and other antigen presenting cells in gut mucosa from patients with SpA and Crohn's disease, given the relationship between both entities.
De Rycke, L, Verhelst, X, Kruithof, E, Hoffman, I, Veys, E, ...
Patients and methods: 62 patients with refractory RA were treated with infliximab combined with methotrexate. At baseline and week 30, serum samples were tested for IgM RF by two agglutination...
Hoffman, I, Peene, I, Cebecauer, L, Isenberg, D, Huizinga, T, Union, A, ...
Kruithof, E, Baeten, D, Mielants, H, Veys, E, De Keyser, F
Objective: To confirm and extend the immunopathological evidence of effects of infliximab on the synovium in active spondyloarthropathy.
Laukens, D, Peeters, H, Marichal, D, Vander, C, Mielants, H, Elewaut, D, ...
Background: The association between spondyloarthropathy and Crohn's disease is well known. A risk for evolution to Crohn's disease has already been shown in the subgroup of patients with...
X linked agammaglobulinaemia and rheumatoid arthritis
Verbruggen, G, De Backer, S, Deforce, D, Demetter, P, Cuvelier, C, Veys, E, ...
Case report: A patient with X linked agammaglobulinaemia (XLA) presented with an erosive symmetric polyarthritis with histological features of RA, including formation of a destructive pannus....
Anti-citrullinated peptide antibodies may occur in patients with psoriatic arthritis
Vander, C, Hoffman, I, Zmierczak, H, Kruithof, E, De Rycke, L, ...
Background: Anti-cyclic citrullinated peptide (anti-CCP) antibodies are considered highly specific markers of rheumatoid arthritis. Despite the high specificity of the test, anti-CCP antibodies have...
Carron, P, Hoffman, I, De Rycke, L, Peene, I, Veys, E, De Keyser, F, ...
Cantaert, T, Coucke, P, De Rycke, L, Veys, E, De Keyser, F, Baeten, D
Background: Haplotypes of PADI4, encoding for a citrullinating enzyme, were associated with rheumatoid arthritis in a Japanese population. It was suggested they were related to the presence of...
Rihl, M, Kruithof, E, Barthel, C, De Keyser, F, Veys, E, Zeidler, H, ...
Objective: To investigate whether expression of the four members of the neurotrophin (NT) family and their four corresponding receptors is related to synovial inflammation in patients with...