Structural Polymorphism of 441-Residue Tau at Single Residue Resolution (2009)
Marco D. Mukrasch, Stefan Bibow, Jegannath Korukottu, Sadasivam Jeganathan, Jacek Biernat, Christian Griesinger, ...
Alzheimer disease is characterized by abnormal protein deposits in the brain, such as extracellular amyloid plaques and intracellular neurofibrillary tangles. The tangles are made of a protein called...
Entwicklung von Inhibitoren der Tau-Aggregation bei Morbus Alzheimer (2009)
Bulic, Bruno, Pickhardt, Marcus, Schmidt, Boris, Mandelkow, Eva Maria, Waldmann, Herbert, Mandelkow, Eckhard
Development of Tau Aggregation Inhibitors for Alzheimer's Disease (2009)
Bulic, Bruno, Pickhardt, Marcus, Schmidt, Boris, Mandelkow, Eva-Maria, Waldmann, Herbert, Mandelkow, Eckhard
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing (2009)
Wang, Yipeng, Martinez-Vicente, Marta, Krüger, Ulrike, Kaushik, Susmita, Wong, Esther, Mandelkow, Eva-Maria, ...
Aggregation and cleavage are two hallmarks of Tau pathology in Alzheimer disease (AD), and abnormal fragmentation of Tau is thought to contribute to the nucleation of Tau paired helical filaments....
Timm, Thomas, Marx, Alexander, Panneerselvam, Saravanan, Mandelkow, Eckhard, Mandelkow, Eva-Maria
Abstract Protein kinases of the MARK family phosphorylate tau protein in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired...
Rhodanine-Based Tau Aggregation Inhibitors in Cell Models of Tauopathy (2007)
Bulic, Bruno, Pickhardt, Marcus, Khlistunova, Inna, Biernat, Jacek, Mandelkow, Eva-Maria, Mandelkow, Eckhard, ...
Rhodanine-Based Tau Aggregation Inhibitors in Cell Models of Tauopathy (2007)
Bulic, Bruno, Pickhardt, Marcus, Khlistunova, Inna, Biernat, Jacek, Mandelkow, Eva-Maria, Mandelkow, Eckhard, ...
The structure of motor-MAP-microtubule interactions (2006)
Marx, Alexander, Müller, Jens, Mandelkow, Eva-Maria, Hoenger, Andreas, Mandelkow, Eckhard
Modulation of kinesin binding by the C-termini of tubulin (2004)
Skiniotis, Georgios, Cochran, Jared C., Müller, Jens, Mandelkow, Eckhard, Gilbert, Susan P., Hoenger, Andreas
MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons (2004)
Mandelkow, Eva-Maria, Thies, Edda, Trinczek, Bernhard, Biernat, Jacek, Mandelkow, Eckhard
Surface-decoration of Microtubules by Human Tau (2004)
Santarella, Rachel A., Skiniotis, Georgios, Goldie, Kenneth N., Tittmann, Peter, Gross, Heinz, Mandelkow, Eva-Maria, ...
Pickhardt, Marcus, Gazova, Zuzana, Von Bergen, Martin, Khlistunova, Inna, Wang, Yipeng, Hascher, Antje, ...
Single-molecule investigation of the interference between kinesin, tau and MAP2c (2002)
Seitz, Arne, Kojima, Hiroaki, Oiwa, Kazuhiro, Mandelkow, Eva-Maria, Song, Young-Hwa, Mandelkow, Eckhard
Motor proteins and microtubule-associated proteins (MAPs) play important roles in cellular transport, regulation of shape and polarity of cells. While motor proteins generate motility, MAPs are...
Biernat, Jacek, Wu, Yong-Zhong, Timm, Thomas, Zheng-Fischhöfer, Qingyi, Mandelkow, Eckhard, Meijer, Laurent, ...
Protein kinases of the microtubule affinity-regulating kinase (MARK) family were originally discovered because of their ability to phosphorylate certain sites in tau protein (KXGS motifs in the...
Li, Li, Von Bergen, Martin, Mandelkow, Eva-Maria, Mandelkow, Eckhard
By using tryptophan scanning mutagenesis, we observed the kinetics and structure of the polymerization of tau into paired helical filaments (PHFs) independently of exogenous reporter dyes. The...
Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd (2002)
Wendt, Thomas G., Volkmann, Niels, Skiniotis, Georgios, Goldie, Kenneth N., Müller, Jens, Mandelkow, Eckhard, ...
We used cryo-electron microscopy and image reconstruction to investigate the structure and microtubule-binding configurations of dimeric non-claret disjunctional (ncd) motor domains under various...
Kinesin motors and disease (2002)
Mandelkow, Eckhard, Mandelkow, Eva-Maria
Kinesins are motor proteins that move cargoes such as vesicles, organelles and chromosomes along microtubules. They are best known for their role in axonal transport and in mitosis. There is a...
Röntgenstrukturuntersuchungen am Tabakmosaikvirus. (1973)
Heidelberg, Univ., Naturwiss. Gesamtfak., Diss. 1973. (Nicht f. d. Austausch.).
Illenberger, Susanne, Zheng-Fischhöfer, Qingyi, Preuss, Ute, Stamer, Karsten, Baumann, Karlheinz, Trinczek, Bernhard, ...
In Alzheimer’s disease the neuronal microtubule-associated protein tau becomes highly phosphorylated, loses its binding properties, and aggregates into paired helical filaments. There is increasing...
Single-molecule investigation of the interference between kinesin, tau and MAP2c
Seitz, Arne, Kojima, Hiroaki, Oiwa, Kazuhiro, Mandelkow, Eva-Maria, Song, Young-Hwa, Mandelkow, Eckhard
Motor proteins and microtubule-associated proteins (MAPs) play important roles in cellular transport, regulation of shape and polarity of cells. While motor proteins generate motility, MAPs are...
Protein Kinase MARK/PAR-1 Is Required for Neurite Outgrowth and Establishment of Neuronal Polarity
Biernat, Jacek, Wu, Yong-Zhong, Timm, Thomas, Zheng-Fischhöfer, Qingyi, Mandelkow, Eckhard, Meijer, Laurent, ...
Protein kinases of the microtubule affinity-regulating kinase (MARK) family were originally discovered because of their ability to phosphorylate certain sites in tau protein (KXGS motifs in the...
Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd
Wendt, Thomas G., Volkmann, Niels, Skiniotis, Georgios, Goldie, Kenneth N., Müller, Jens, Mandelkow, Eckhard, ...
We used cryo-electron microscopy and image reconstruction to investigate the structure and microtubule-binding configurations of dimeric non-claret disjunctional (ncd) motor domains under various...
Nucleotide-induced conformations in the neck region of dimeric kinesin
Skiniotis, Georgios, Surrey, Thomas, Altmann, Stephan, Gross, Heinz, Song, Young-Hwa, Mandelkow, Eckhard, ...
The neck region of kinesin constitutes a key component in the enzyme’s walking mechanism. Here we applied cryoelectron microscopy and image reconstruction to investigate the location of the kinesin...
MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1
Timm, Thomas, Li, Xiao-Yu, Biernat, Jacek, Jiao, Jian, Mandelkow, Eckhard, Vandekerckhove, Joel, ...
MARK, a kinase family related to PAR-1 involved in establishing cell polarity, phosphorylates microtubule-associated proteins (tau/MAP2/MAP4) at KXGS motifs, causes detachment from microtubules, and...
Modulation of kinesin binding by the C-termini of tubulin
Skiniotis, Georgios, Cochran, Jared C, Müller, Jens, Mandelkow, Eckhard, Gilbert, Susan P, Hoenger, Andreas
The flexible tubulin C-terminal tails (CTTs) have recently been implicated in the walking mechanism of dynein and kinesin. To address their role in the case of conventional kinesin, we examined the...
PAK5 Kinase Is an Inhibitor of MARK/Par-1, Which Leads to Stable Microtubules and Dynamic ActinD⃞
Matenia, Dorthe, Griesshaber, Bettina, Li, Xiao-yu, Thiessen, Anja, Johne, Cindy, Jiao, Jian, ...
MARK/Par-1 is a kinase involved in development of embryonic polarity. In neurons, MARK phosphorylates tau protein and causes its detachment from microtubules, the tracks of axonal transport. Because...
Inhibition of APP Trafficking by Tau Protein Does Not Increase the Generation of Amyloid-β Peptides
Goldsbury, Claire, Mocanu, Maria-Magdalena, Thies, Edda, Kaether, Christoph, Haass, Christian, Keller, Patrick, ...
Amyloid-β, a peptide derived from the precursor protein APP, accumulates in the brain and contributes to the neuropathology of Alzheimer's disease. Increased generation of amyloid-β might be caused...
Illenberger, Susanne, Zheng-Fischhöfer, Qingyi, Preuss, Ute, Stamer, Karsten, Baumann, Karlheinz, Trinczek, Bernhard, ...
In Alzheimer’s disease the neuronal microtubule-associated protein tau becomes highly phosphorylated, loses its binding properties, and aggregates into paired helical filaments. There is increasing...
Single-molecule investigation of the interference between kinesin, tau and MAP2c
Seitz, Arne, Kojima, Hiroaki, Oiwa, Kazuhiro, Mandelkow, Eva-Maria, Song, Young-Hwa, Mandelkow, Eckhard
Motor proteins and microtubule-associated proteins (MAPs) play important roles in cellular transport, regulation of shape and polarity of cells. While motor proteins generate motility, MAPs are...
Protein Kinase MARK/PAR-1 Is Required for Neurite Outgrowth and Establishment of Neuronal Polarity
Biernat, Jacek, Wu, Yong-Zhong, Timm, Thomas, Zheng-Fischhöfer, Qingyi, Mandelkow, Eckhard, Meijer, Laurent, ...
Protein kinases of the microtubule affinity-regulating kinase (MARK) family were originally discovered because of their ability to phosphorylate certain sites in tau protein (KXGS motifs in the...
Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd
Wendt, Thomas G., Volkmann, Niels, Skiniotis, Georgios, Goldie, Kenneth N., Müller, Jens, Mandelkow, Eckhard, ...
We used cryo-electron microscopy and image reconstruction to investigate the structure and microtubule-binding configurations of dimeric non-claret disjunctional (ncd) motor domains under various...
Nucleotide-induced conformations in the neck region of dimeric kinesin
Skiniotis, Georgios, Surrey, Thomas, Altmann, Stephan, Gross, Heinz, Song, Young-Hwa, Mandelkow, Eckhard, ...
The neck region of kinesin constitutes a key component in the enzyme’s walking mechanism. Here we applied cryoelectron microscopy and image reconstruction to investigate the location of the kinesin...
MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1
Timm, Thomas, Li, Xiao-Yu, Biernat, Jacek, Jiao, Jian, Mandelkow, Eckhard, Vandekerckhove, Joel, ...
MARK, a kinase family related to PAR-1 involved in establishing cell polarity, phosphorylates microtubule-associated proteins (tau/MAP2/MAP4) at KXGS motifs, causes detachment from microtubules, and...
Modulation of kinesin binding by the C-termini of tubulin
Skiniotis, Georgios, Cochran, Jared C, Müller, Jens, Mandelkow, Eckhard, Gilbert, Susan P, Hoenger, Andreas
The flexible tubulin C-terminal tails (CTTs) have recently been implicated in the walking mechanism of dynein and kinesin. To address their role in the case of conventional kinesin, we examined the...
PAK5 Kinase Is an Inhibitor of MARK/Par-1, Which Leads to Stable Microtubules and Dynamic ActinD⃞
Matenia, Dorthe, Griesshaber, Bettina, Li, Xiao-yu, Thiessen, Anja, Johne, Cindy, Jiao, Jian, ...
MARK/Par-1 is a kinase involved in development of embryonic polarity. In neurons, MARK phosphorylates tau protein and causes its detachment from microtubules, the tracks of axonal transport. Because...
Protein Crystallography at PETRA-III: Proposal for a sector with two beamlines
Bartunik, Hans Dieter, Bourenkov, Gleb, Mandelkow, Eckhard, Betzel, Christian, Hilgenfeld, Rolf
Domains of Neuronal Microtubule-associated Proteins and Flexural Rigidity of Microtubules
Felgner, Harald, Frank, Rainer, Biernat, Jacek, Mandelkow, Eva-Maria, Mandelkow, Eckhard, Ludin, Beat, ...
Microtubules are flexible polymers whose mechanical properties are an important factor in the determination of cell architecture and function. It has been proposed that the two most prominent...
Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein
Timm, Thomas, Marx, Alexander, Panneerselvam, Saravanan, Mandelkow, Eckhard, Mandelkow, Eva-Maria
Protein kinases of the MARK family phosphorylate tau protein in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical...
Structural Polymorphism of 441-Residue Tau at Single Residue Resolution
Mukrasch, Marco D, Bibow, Stefan, Korukottu, Jegannath, Jeganathan, Sadasivam, Biernat, Jacek, Griesinger, Christian, ...
Alzheimer disease is characterized by abnormal protein deposits in the brain, such as extracellular amyloid plaques and intracellular neurofibrillary tangles. The tangles are made of a protein called...