Transplantation of selected or transgenic blood stem cells – a future treatment for HIV/AIDS? (2009)
Hütter, Gero, Schneider, Thomas, Thiel, Eckhard
Abstract Interaction with the chemokine receptor, CCR5, is a necessary precondition for maintaining HIV-1 infection. Individuals with the CCR5-delta32 deletion who lack this receptor are highly...
An intron 9 containing splice variant of PAX2 (2009)
Busse, Antonia, Rietz, Anika, Schwartz, Stefan, Thiel, Eckhard, Keilholz, Ulrich
Abstract Background PAX2 is a transcription factor with an important role in embryogenic development. However, PAX2 expression was frequently identified in neoplasia responsible for the growth and...
Hütter, Gero, Letsch, Anne, Nowak, Daniel, Poland, Julia, Sinha, Pranav, Thiel, Eckhard, ...
Abstract Background When comparing myelogenous blasts from bone marrow and peripheral blood, immunophenotyping usually show a strong correlation of expression of surface antigens. However, it remains...
Maza, Sofiane, Kiewe, Philipp, Munz, Dieter L., Korfel, Agnieszka, Hamm, Bernd, Jahnke, Kristoph, ...
Most patients with primary CNS lymphoma (PCNSL) relapse after primary therapy. Standard salvage treatment has not yet been established in PCNSL. Anti-CD20 immunotherapy has expanded treatment options...
Differential Effects of a Stem Cell Factor-Immunoglobulin Fusion Protein on (2008)
Normal Hematopoietic Cells, Ulrike Erben, Eckhard Thiel, Michael Notter
We genetically connected the extracellular domain of human stem cell factor to the Fc-portion of human IgG1. The chimeric recombinant stem cell factor IgG1 fusion protein (rSCF-IgG1) had an apparent...
Ochsenreither, Sebastian, Fusi, Alberto, Busse, Antonia, Nagorsen, Dirk, Schrama, David, Becker, Jürgen, ...
Abstract Background Quantification of T-cell receptor (TCR) chain families can be utilized for detection of clonal T-cell populations. Besides southern blotting and antibody-based approaches,...
Dirk Bottke, Daniel Koychev, Antonia Busse, Karin Heufelder, Thomas Wiegel, Eckhard Thiel, ...
Bottke, D., Koychev, D., Busse, A., Heufelder, K., Wiegel, T., Thiel, E., Hinkelbein, W. and Keilholz, U. Fractionated Irradiation Can Induce Functionally Relevant Multidrug Resistance Gene and...
Burmeister, Thomas, Meyer, Claus, Thiel, Gundula, Reinhardt, Richard, Thiel, Eckhard, Marschalek, Rolf
MLL aberrations are found in approximately 10% of acute leukemias. More than 80 different MLL fusion genes have been cytogenetically described but a significant number of MLL fusion partners remain...
Nagorsen, Dirk, Voigt, Sabine, Berg, Erika, Stein, Harald, Thiel, Eckhard, Loddenkemper, Christoph
Abstract Introduction Although systemic T-cell responses against tumor antigens and tumor infiltration by T cells have been investigated in colorectal cancer (CRC), the initiation of spontaneous...
Burmeister, Thomas, Schwartz, Stefan, Hummel, Michael, Hoelzer, Dieter, Thiel, Eckhard
Abstract Background The Deltaretrovirus genus comprises viruses that infect humans (HTLV), various simian species (STLV) and cattle (BLV). HTLV-I is the main causative agent in adult T-cell leukemia...
Kiewe, Philipp, Loddenkemper, Christoph, Anagnostopoulos, Ioannis, Reinwald, Mark, Thiel, Eckhard, Korfel, Agnieszka
In patients with parenchymal brain masses of uncertain origin responsive to corticosteroids, primary CNS lymphoma (PCNSL) should be considered. PCNSL is a rare but aggressive brain tumor that is...
Kiewe, Philipp, Loddenkemper, Christoph, Anagnostopoulos, Ioannis, Reinwald, Mark, Thiel, Eckhard, Korfel, Agnieszka
In patients with parenchymal brain masses of uncertain origin responsive to corticosteroids, primary CNS lymphoma (PCNSL) should be considered. PCNSL is a rare but aggressive brain tumor that is...
Petrausch, Ulf, Dernedde, Jens, Coelho, Vânia, Panjideh, Hossein, Frey, Dietmar, Fuchs, Hendrik, ...
Chemical conjugates of monoclonal antibodies with fluorophores or enzymes have long been used for diagnostic purposes and experimental therapeutic approaches. Recombinant technology allows for the...
Kiewe, Philipp, Loddenkemper, Christoph, Anagnostopoulos, Ioannis, Reinwald, Mark, Thiel, Eckhard, Korfel, Agnieszka
In patients with parenchymal brain masses of uncertain origin responsive to corticosteroids, primary CNS lymphoma (PCNSL) should be considered. PCNSL is a rare but aggressive brain tumor that is...
In situ analysis of FOXP3+ regulatory T cells in human colorectal cancer (2006)
Loddenkemper, Christoph, Schernus, Martin, Noutsias, Michel, Stein, Harald, Thiel, Eckhard, Nagorsen, Dirk
Abstract The immune system spontaneously responds to tumor-associated antigens in peripheral blood of colorectal cancer (CRC) patients. Regulatory T cells (Treg) are suspected of influencing the...
Burmeister, Thomas, MacLeod, Roderick A. F., Reinhardt, Richard, Mansmann, Veit, Loddenkemper, Christoph, Marinets, Olga, ...
We report the establishment and characterization, including HLA-typing, immunophenotypic and molecular cytogenetic analysis, of a novel EBV-negative cell line (BLUE-1) derived from adult relapsed...
Nagorsen, Dirk, Scheibenbogen, Carmen, Letsch, Anne, Germer, Christoph-Thomas, Buhr, Heinz-Johannes, Hegewisch-Becker, Susanna, ...
Abstract Introduction Spontaneous T cell responses against specific tumor-associated antigens (TAA) are frequently detected in peripheral blood of tumor patients of various histiotypes. However,...
Tübingen, Med. F., Diss. v. 4. Aug. 1969.
Thesis (doctoral)--Eberhard-Karls-Universität zu Tübingen, 1969.
T cell responses against tumor associated antigens and prognosis in colorectal cancer patients
Nagorsen, Dirk, Scheibenbogen, Carmen, Letsch, Anne, Germer, Christoph-Thomas, Buhr, Heinz-Johannes, Hegewisch-Becker, Susanna, ...
Mutation Analysis of hCDC4 in AML Cells Identifies a New Intronic Polymorphism
Nowak, Daniel, Mossner, Maximilian, Baldus, Claudia D., Hopfer, Olaf, Thiel, Eckhard, Hofmann, Wolf-Karsten
hCDC4 (FBW7, FBXW7) is a new potential tumor suppressor gene which provides substrate specificity for SCF (Skp–Cullin–F-box) ubiquitin ligases and thereby regulates the degradation of potent...
T cell responses against tumor associated antigens and prognosis in colorectal cancer patients
Nagorsen, Dirk, Scheibenbogen, Carmen, Letsch, Anne, Germer, Christoph-Thomas, Buhr, Heinz-Johannes, Hegewisch-Becker, Susanna, ...
Mutation Analysis of hCDC4 in AML Cells Identifies a New Intronic Polymorphism
Nowak, Daniel, Mossner, Maximilian, Baldus, Claudia D., Hopfer, Olaf, Thiel, Eckhard, Hofmann, Wolf-Karsten
hCDC4 (FBW7, FBXW7) is a new potential tumor suppressor gene which provides substrate specificity for SCF (Skp–Cullin–F-box) ubiquitin ligases and thereby regulates the degradation of potent...
In situ analysis of FOXP3+ regulatory T cells in human colorectal cancer
Loddenkemper, Christoph, Schernus, Martin, Noutsias, Michel, Stein, Harald, Thiel, Eckhard, Nagorsen, Dirk
The immune system spontaneously responds to tumor-associated antigens in peripheral blood of colorectal cancer (CRC) patients. Regulatory T cells (Treg) are suspected of influencing the interaction...
Kiewe, Philipp, Loddenkemper, Christoph, Anagnostopoulos, Ioannis, Reinwald, Mark, Thiel, Eckhard, Korfel, Agnieszka
In patients with parenchymal brain masses of uncertain origin responsive to corticosteroids, primary CNS lymphoma (PCNSL) should be considered. PCNSL is a rare but aggressive brain tumor that is...
Ochsenreither, Sebastian, Fusi, Alberto, Busse, Antonia, Nagorsen, Dirk, Schrama, David, Becker, Jürgen, ...
Fischer, Lars, Gökbuget, Nicola, Schwartz, Stefan, Burmeister, Thomas, Rieder, Harald, Brüggemann, Monika, ...
The findings of this study indicate that CD56 is expressed on a subset of adult T-cell acute lymphoblastic leukemia cells with distinct immunophenotypic features and greater resistance to therapy....
An intron 9 containing splice variant of PAX2
Busse, Antonia, Rietz, Anika, Schwartz, Stefan, Thiel, Eckhard, Keilholz, Ulrich
Transplantation of selected or transgenic blood stem cells – a future treatment for HIV/AIDS?
Hütter, Gero, Schneider, Thomas, Thiel, Eckhard
Interaction with the chemokine receptor, CCR5, is a necessary precondition for maintaining HIV-1 infection. Individuals with the CCR5-delta32 deletion who lack this receptor are highly resistant to...
Diagnosis and management of primary intraocular lymphoma: an update
Jahnke, Kristoph, Thiel, Eckhard, Abrey, Lauren E, Neuwelt, Edward A, Korfel, Agnieszka
Despite recent advances in diagnosis and treatment, the prognosis of primary intraocular lymphoma (PIOL) remains poor, and the optimal treatment has yet to be defined. This review presents an...
Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia
Baldus, Claudia D., Thibaut, Julia, Goekbuget, Nicola, Stroux, Andrea, Schlee, Cornelia, Mossner, Max, ...
NOTCH1 mutations are found in more than 50 % of patients with T-lineage acute lymphoblastic leukemia (TALL), and have been associated with a favorable outcome in pediatric T-ALL. FBXW7 mutations are...