Kim, Taesung, Kao, Ming-Tse, Meyhöfer, Edgar, Hasselbrink, Ernest F
We suggest a concept for powering microfluidic devices with biomolecular motors and microtubules to meet the demands for highly efficient microfluidic devices. However, to successfully implement such...
Back on track – On the role of the microtubule for kinesin motility and cellular function (2006)
Lakämper, Stefan, Meyhöfer, Edgar
The evolution of cytoskeletal filaments (actin- and intermediate-filaments, and the microtubules) and their associated motor- and non-motor-proteins has enabled the eukaryotic cell to achieve complex...
A Theoretical Model of a Molecular-Motor-Powered Pump (2005)
Bull, Joseph L., Hunt, Alan J., Meyhöfer, Edgar
The motion of a cylindrical bead in a fluid contained within a two-dimensional channel is investigated using the boundary element method as a model of a biomolecular-motor-powered microfluidics pump....
Toxoplasma gondii myosin A and its light chain: a fast, single-headed, plusend directed motor (2002)
Herm-Götz,Angelika, Weiss,Stefan, Stratmann,Rolf, Fujita-Becker,Setsuko, Ruff,Christine, Meyhöfer,Edgar, ...
Successful host cell invasion is a prerequisite for survival of the obligate intracellular apicomplexan parasites and establishment of infection. Toxoplasma gondii penetrates host cells by an active...
Toxoplasma gondii myosin A and its light chain: a fast, single-headed, plusend directed motor (2002)
Herm-Götz,Angelika, Weiss,Stefan, Stratmann,Rolf, Fujita-Becker,Setsuko, Ruff,Christine, Meyhöfer,Edgar, ...
Successful host cell invasion is a prerequisite for survival of the obligate intracellular apicomplexan parasites and establishment of infection. Toxoplasma gondii penetrates host cells by an active...
Toxoplasma gondii myosin A and its light chain: a fast, single-headed, plusend directed motor (2002)
Herm-Götz, Angelika, Weiss, Stefan, Stratmann, Rolf, Fujita-Becker, Setsuko, Ruff, Christine, Meyhöfer, Edgar, ...
Successful host cell invasion is a prerequisite for survival of the obligate intracellular apicomplexan parasites and establishment of infection. Toxoplasma gondii penetrates host cells by an active...
Toxoplasma gondii myosin A and its light chain: a fast, single-headed, plusend directed motor (2002)
Herm-Götz, Angelika, Weiss, Stefan, Stratmann, Rolf, Fujita-Becker, Setsuko, Ruff, Christine, Meyhöfer, Edgar, ...
Successful host cell invasion is a prerequisite for survival of the obligate intracellular apicomplexan parasites and establishment of infection. Toxoplasma gondii penetrates host cells by an active...
Single-molecule tracking of myosins with genetically engineered amplifier domains (2001)
Ruff,Christine, Furch,Marcus, Brenner,Bernhard, Manstein,Dietmar J., Meyhöfer,Edgar
We combined protein engineering and single molecule measurements to directly record the step size of a series of myosin constructs with shortened and elongated artificial neck domains. Our results...
Single-molecule tracking of myosins with genetically engineered amplifier domains (2001)
Ruff, Christine, Furch, Marcus, Brenner, Bernhard, Manstein, Dietmar J., Meyhöfer, Edgar
We combined protein engineering and single molecule measurements to directly record the step size of a series of myosin constructs with shortened and elongated artificial neck domains. Our results...
Unusual properties of the fungal conventional kinesin neck domain from Neurospora crassa
Kallipolitou, Athina, Deluca, Dominga, Majdic, Ulrike, Lakämper, Stefan, Cross, Robert, Meyhöfer, Edgar, ...
Fungal conventional kinesins are unusually fast microtubule motor proteins. To compare the functional organization of fungal and animal conventional kinesins, a set of C-terminal deletion mutants of...
Toxoplasma gondii myosin A and its light chain: a fast, single-headed, plus-end-directed motor
Herm-Götz, Angelika, Weiss, Stefan, Stratmann, Rolf, Fujita-Becker, Setsuko, Ruff, Christine, Meyhöfer, Edgar, ...
Successful host cell invasion is a prerequisite for survival of the obligate intracellular apicomplexan parasites and establishment of infection. Toxoplasma gondii penetrates host cells by an active...
Optics at critical intensity: Applications to nanomorphing
Joglekar, Ajit P., Liu, Hsiao-hua, Meyhöfer, Edgar, Mourou, Gerard, Hunt, Alan J.
Laser-induced optical breakdown by femtosecond pulses is extraordinarily precise when the energy is near threshold. Despite numerous applications, the basis for this deterministic nature has not been...
Single Fungal Kinesin Motor Molecules Move Processively along Microtubules
Lakämper, Stefan, Kallipolitou, Athina, Woehlke, Günther, Schliwa, Manfred, Meyhöfer, Edgar
Conventional kinesins are two-headed molecular motors that move as single molecules micrometer-long distances on microtubules by using energy derived from ATP hydrolysis. The presence of two heads is...
The E-Hook of Tubulin Interacts with Kinesin's Head to Increase Processivity and Speed
Lakämper, Stefan, Meyhöfer, Edgar
Kinesins are dimeric motor proteins that move processively along microtubules. It has been proposed that the processivity of conventional kinesins is increased by electrostatic interactions between...
Unusual properties of the fungal conventional kinesin neck domain from Neurospora crassa
Kallipolitou, Athina, Deluca, Dominga, Majdic, Ulrike, Lakämper, Stefan, Cross, Robert, Meyhöfer, Edgar, ...
Fungal conventional kinesins are unusually fast microtubule motor proteins. To compare the functional organization of fungal and animal conventional kinesins, a set of C-terminal deletion mutants of...
Toxoplasma gondii myosin A and its light chain: a fast, single-headed, plus-end-directed motor
Herm-Götz, Angelika, Weiss, Stefan, Stratmann, Rolf, Fujita-Becker, Setsuko, Ruff, Christine, Meyhöfer, Edgar, ...
Successful host cell invasion is a prerequisite for survival of the obligate intracellular apicomplexan parasites and establishment of infection. Toxoplasma gondii penetrates host cells by an active...
Optics at critical intensity: Applications to nanomorphing
Joglekar, Ajit P., Liu, Hsiao-hua, Meyhöfer, Edgar, Mourou, Gerard, Hunt, Alan J.
Laser-induced optical breakdown by femtosecond pulses is extraordinarily precise when the energy is near threshold. Despite numerous applications, the basis for this deterministic nature has not been...
Single Fungal Kinesin Motor Molecules Move Processively along Microtubules
Lakämper, Stefan, Kallipolitou, Athina, Woehlke, Günther, Schliwa, Manfred, Meyhöfer, Edgar
Conventional kinesins are two-headed molecular motors that move as single molecules micrometer-long distances on microtubules by using energy derived from ATP hydrolysis. The presence of two heads is...
The E-Hook of Tubulin Interacts with Kinesin's Head to Increase Processivity and Speed
Lakämper, Stefan, Meyhöfer, Edgar
Kinesins are dimeric motor proteins that move processively along microtubules. It has been proposed that the processivity of conventional kinesins is increased by electrostatic interactions between...
Different degrees of lever arm rotation control myosin step size
Köhler, Danny, Ruff, Christine, Meyhöfer, Edgar, Bähler, Martin
Myosins are actin-based motors that are generally believed to move by amplifying small structural changes in the core motor domain via a lever arm rotation of the light chain binding domain. However,...
Tracking Single Kinesin Molecules in the Cytoplasm of Mammalian Cells
Cai, Dawen, Verhey, Kristen J., Meyhöfer, Edgar
Understanding dynamic cellular processes requires precise knowledge of the distribution, transport, and interactions of individual molecules in living cells. Despite recent progress in in vivo...
Intrinsic Curvature of DNA Influences LacR-Mediated Looping
Goyal, Sachin, Lillian, Todd, Blumberg, Seth, Meiners, Jens-Christian, Meyhöfer, Edgar, Perkins, N. C.
Protein-mediated DNA looping is a common mechanism for regulating gene expression. Loops occur when a protein binds to two operators on the same DNA molecule. The probability of looping is...
Nanomechanical Model of Microtubule Translocation in the Presence of Electric Fields
Kim, Taesung, Kao, Ming-Tse, Hasselbrink, Ernest F., Meyhöfer, Edgar
Research efforts in recent years have been directed toward actively controlling the direction of translocation of microtubules on a kinesin-coated glass surface with E-fields (electric fields),...