JPET Fast Forward. Published on April 19, 2007 as DOI:10.1124/jpet.107.123109 1 (2008)
Robert Schwarcz, Edson X. Albuquerque
Competitive antagonism between the nicotinic allosteric potentiating ligand galantamine and kynurenic acid at α7 * nicotinic receptors
Manickavasagom Alkondon, Edson X. Albuquerque, J Neurophysiol, L. Jiang, L. W. Role, J. A. Davis, ...
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The major goals of this project have been: a) to continue our investigation of organophosphorus compounds (OPs) on chemosensitive receptors located at various synapses; b) to attempt to discern the...
The Acetylcholine Receptor and Its Ionic Channel as Targets for Drugs and Toxins (2002)
Eldefrawi, Mohyee E., Albuquerque, Edson X.
The overall objective of this study was to establish the pharmacology of the ionic channel of the peripheral nicotinic acetylcholine (ACh) receptor and to understand the mechanism by which this...
Eldefrawi, Mohyee E., Warnick, Jordan E., Schofield, G. G., Albuquerque, Edson X., Eldefrawi, Amira T.
Aguayo, L. G., Pazhenchevsky, B., Daly, J. W., Albuquerque, Edson X.
Sponsored in part by Grant PHS-NS-12063.
Tiedt, Thomas N., Albuquerque, Edson X., Bakry, Nabil M., Eldefrawi, Mohyee E., Eldefrawi, Amira T.
Sponsored in part by Grant NSF-BNS76-21683
Sites of Action of Phencyclidine. III. Interactions with Muscarinic Receptors (2002)
Aronstam, Robert S., Eldefrawi, Mohyee E., Eldefrawi, Amira T., Albuquerque, Edson X., Jim, Kam F.
Sponsored in part by Grants PHS-NS-12063 and PHS-HL-16003
Nereistoxin Interaction with the Acetylcholine Receptor-Ionic Channel Complex (2002)
Eldefrawi, Amira T., Bakry, Nabil M., Eldefrawi, Mohyee E., Tsai, Ming-Cheng, Albuquerque, Edson X.
Sponsored in part by Grants PHS-NS-15261 and PHS-NS-12063
Tsai, Ming-Cheng, Albuquerque, Edson X., Aronstam, Robert S., Eldefrawi, Amira T., Eldefrawi, Mohyee E.
See also AD-A109 356. Sponsored in part by grants PHS-NS- 15261 and PHS-HL-16003
Brown, George B., Tieszen, Stuart C., Daly, John W., Warnick, Jordan E., Albuquerque, Edson X.
Sponsored in part by Grant PHS-NS-12063
Eldefrawi, Mohyee E., Aronstam, Robert S., Bakry, Nabil M., Eldefrawi, Amira T., Albuquerque, Edson X.
Sponsored in part by Grant PHS-NS-12063.
Synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0]octane derivative (2001)
Peçanha,Emerson P., Fraga,Carlos A. M., Barreiro,Eliezer J., Braga,Maria F. M., Pereira,Edna F. R., Albuquerque,Edson X.
As part of a research program aiming at the design, synthesis and pharmacological evaluation of a novel lead-candidates of neuroactive compounds, we describe herein the synthesis and the central...
Máriton D. Santos, Manickavasagom Alkondon, Yasco Aracava, Howard M. Eisenberg, Alfred Maelicke, ...
In this study, the patch-clamp technique was used to determine the effects of galantamine, a cholinesterase inhibitor and a nicotinic allosteric potentiating ligand (APL) used for treatment of...
REDDY, VANGA K., DESHPANDE, SHARAD S., CINTRA, WAGNER M., SCOBLE, GILES T., ALBUQUERQUE, EDSON X.
Effectiveness of Oximes 2-PAM and HI-6 in Recovery of Muscle Function Depressed by Organophosphate Agents in the Rat Hemidiaphragm: An in vitro Study. REDDY, V. K., DESHPANDE, S. S., CINTRA, W. M.,...
DESHPANDE, SHARAD S., VIANA, GLAUCE B., KAUFFMAN, FREDERICK C., RICKETT, DANIEL L., ALBUQUERQUE, EDSON X.
Effectiveness of Physostigmine as a Pretreatment Drug for Protection of Rats from Organophosphate Poisoning. DESHPANDE, S. S., VIANA, G. B., KAUFFMAN, F. C., RICKETT, D. L., AND ALBUQUERQUE, E. X....
Albuquerque, Edson X., Tsai, Ming-Cheng, Aronstam, Robert S., Witkop, Bernhard, Eldefrawi, Amira T., Eldefrawi, Mohyee E.
The effects of phencyclidine (PCP) were studied on the electrogenic and chemosensitive properties of the neuromuscular junction of skeletal muscle as well as on the binding sites on the acetylcholine...
Eldefrawi, Mohyee E., Aronstam, Robert S., Bakry, Nabil M., Eldefrawi, Amira T., Albuquerque, Edson X.
The effects of receptor activation were studied on the interaction of perhydrohistrionicotoxin (H12-HTX) with the ionic channel of the nicotinic acetylcholine (AcCho) receptor in membranes from the...
Adler, Michael, Oliveira, Antonio C., Eldefrawi, Mohyee E., Eldefrawi, Amira T., Albuquerque, Edson X.
Tetraethylammonium (Et4N+) ions depressed the amplitude and accelerated the decay rate of spontaneously occurring and nerve-evoked endplate currents (EPCs) in frog sartorius muscle. The relationship...
Albuquerque, Edson X., Barnard, Eric A., Porter, Carl W., Warnick, Jordan E.
In various skeletal muscles, the mean density of acetylcholine receptors in the muscle postsynaptic membrane is constant at about 8700 per μm2, even though the overall size of an endplate ranged...
Albuquerque, Edson X., Barnard, Eric A., Chiu, Tieh H., Lapa, Antonio J., Dolly, J. Oliver, Jansson, Sten-Erik, ...
The perhydro derivative of histrionicotoxin reversibly blocks the excitatory ionic transduction system in the synaptic and sarcolemmal membranes of mammalian skeletal muscle cells. The efficacy of...
Albuquerque, Edson X., Tsai, Ming-Cheng, Aronstam, Robert S., Witkop, Bernhard, Eldefrawi, Amira T., Eldefrawi, Mohyee E.
The effects of phencyclidine (PCP) were studied on the electrogenic and chemosensitive properties of the neuromuscular junction of skeletal muscle as well as on the binding sites on the acetylcholine...
Eldefrawi, Mohyee E., Aronstam, Robert S., Bakry, Nabil M., Eldefrawi, Amira T., Albuquerque, Edson X.
The effects of receptor activation were studied on the interaction of perhydrohistrionicotoxin (H12-HTX) with the ionic channel of the nicotinic acetylcholine (AcCho) receptor in membranes from the...
Adler, Michael, Oliveira, Antonio C., Eldefrawi, Mohyee E., Eldefrawi, Amira T., Albuquerque, Edson X.
Tetraethylammonium (Et4N+) ions depressed the amplitude and accelerated the decay rate of spontaneously occurring and nerve-evoked endplate currents (EPCs) in frog sartorius muscle. The relationship...
Albuquerque, Edson X., Barnard, Eric A., Porter, Carl W., Warnick, Jordan E.
In various skeletal muscles, the mean density of acetylcholine receptors in the muscle postsynaptic membrane is constant at about 8700 per μm2, even though the overall size of an endplate ranged...
Albuquerque, Edson X., Barnard, Eric A., Chiu, Tieh H., Lapa, Antonio J., Dolly, J. Oliver, Jansson, Sten-Erik, ...
The perhydro derivative of histrionicotoxin reversibly blocks the excitatory ionic transduction system in the synaptic and sarcolemmal membranes of mammalian skeletal muscle cells. The efficacy of...
Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents
Albuquerque, Edson X., Pereira, Edna F. R., Aracava, Yasco, Fawcett, William P., Oliveira, Maristela, Randall, William R., ...
The nerve agents soman, sarin, VX, and tabun are deadly organophosphorus (OP) compounds chemically related to OP insecticides. Most of their acute toxicity results from the irreversible inhibition of...
A Study of the Reinnervation of Fast and Slow Mammalian Muscles
McArdle, Joseph J., Albuquerque, Edson X.
Miniature end plate potential (mepp) frequency in innervated extensor muscle is significantly higher than in soleus muscle. 9 days after nerve crush mepps of low amplitude and prolonged duration...
Effects of Batrachotoxin on Membrane Potential and Conductance of Squid Giant Axons
Narahashi, Toshio, Albuquerque, Edson X., Deguchi, Takehiko
The effects of batrachotoxin (BTX) on the membrane potential and conductances of squid giant axons have been studied by means of intracellular microelectrode recording, internal perfusion, and...