Edward C. Hsiao

Characterization of Growth-Differentiation Factor 15, a Transforming Growth Factor β Superfamily Member Induced following Liver Injury

Hsiao, Edward C., Koniaris, Leonidas G., Zimmers-Koniaris, Teresa, Sebald, Suzanne M., Huynh, Thanh V., Lee, Se-Jin

We have identified a new murine transforming growth factor β superfamily member, growth-differentiation factor 15 (Gdf15), that is expressed at highest levels in adult liver. As determined by...

Characterization of Growth-Differentiation Factor 15, a Transforming Growth Factor β Superfamily Member Induced following Liver Injury

Hsiao, Edward C., Koniaris, Leonidas G., Zimmers-Koniaris, Teresa, Sebald, Suzanne M., Huynh, Thanh V., Lee, Se-Jin

We have identified a new murine transforming growth factor β superfamily member, growth-differentiation factor 15 (Gdf15), that is expressed at highest levels in adult liver. As determined by...

Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors

Kwon, Chulan, Arnold, Joshua, Hsiao, Edward C., Taketo, Makoto M., Conklin, Bruce R., Srivastava, Deepak

Guiding multipotent cells into distinct lineages and controlling their expansion remain fundamental challenges in developmental and stem cell biology. Members of the Wnt pathway control many pivotal...

Modifying Ligand-Induced and Constitutive Signaling of the Human 5-HT4 Receptor

Chang, Wei Chun, Ng, Jennifer K., Nguyen, Trieu, Pellissier, Lucie, Claeysen, Sylvie, Hsiao, Edward C., ...

G protein–coupled receptors (GPCRs) signal through a limited number of G-protein pathways and play crucial roles in many biological processes. Studies of their in vivo functions have been hampered...

Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass

Hsiao, Edward C., Boudignon, Benjamin M., Chang, Wei C., Bencsik, Margaret, Peng, Jeffrey, Nguyen, Trieu D., ...

Osteoblasts are essential for maintaining bone mass, avoiding osteoporosis, and repairing injured bone. Activation of osteoblast G protein-coupled receptors (GPCRs), such as the parathyroid hormone...