Edward E. Lemmens

Cytosolic Entry Controls CD8+-T-Cell Potency during Bacterial Infection▿

Bahjat, Keith S., Liu, Weiqun, Lemmens, Edward E., Schoenberger, Stephen P., Portnoy, Daniel A., Dubensky, Thomas W., ...

Interaction with host immunoreceptors during microbial infection directly impacts the magnitude of the ensuing innate immune response. How these signals affect the quality of the adaptive T-cell...

Constitutive Activation of the PrfA Regulon Enhances the Potency of Vaccines Based on Live-Attenuated and Killed but Metabolically Active Listeria monocytogenes Strains▿

Lauer, Peter, Hanson, Bill, Lemmens, Edward E., Liu, Weiqun, Luckett, William S., Leong, Meredith L., ...

Recombinant vaccines derived from the facultative intracellular bacterium Listeria monocytogenes are presently undergoing early-stage clinical evaluation in oncology treatment settings. This effort...

Suppression of Cell-Mediated Immunity following Recognition of Phagosome-Confined Bacteria

Bahjat, Keith S., Meyer-Morse, Nicole, Lemmens, Edward E., Shugart, Jessica A., Dubensky, Thomas W., Brockstedt, Dirk G., ...

Listeria monocytogenes is a facultative intracellular pathogen capable of inducing a robust cell-mediated immune response to sub-lethal infection. The capacity of L. monocytogenes to escape from the...