Deconstructing and Reconstructing Obesity-Induced Diabetes (Diabesity) in Mice (2008)
Peter C. Reifsnyder, Edward H. Leiter, Address Correspondence
Obesity-driven type 2 diabetes (diabesity) involves complex genetic and environmental interactions to trigger disease. Here, we combine variable numbers of known quantitative trait loci (QTL) for...
Miller, Aaron L, Komak, Spogmai, Webb, M Scott, Leiter, Edward H, Thompson, E Brad
Abstract Background Glucocorticoids (GC's) play an integral role in treatment strategies designed to combat various forms of hematological malignancies. GCs also are powerful inhibitors of the immune...
Marcia F. McInerney, Sonia M. Najjar, Deanna Brickley, Mary Lutzke, Peter Reifsnyder, ...
The New Zealand obese (NZO) mouse strain shares with the related New Zealand black (NZB) strain a number of immunophenotypic traits. Among these is a high proportion of B-1 B lymphocytes, a subset...
Shultz, Leonard D., Lang, Pamela A., Christianson, Sherri W., Gott, Bruce, Lyons, Bonnie L., Umeda, Syuji, ...
Development of a small animal model for the in vivo study of human immunity and infectious disease remains an important goal, particularly for investigations of HIV vaccine development. NOD/Lt mice...
Mathews, Clayton E., Graser, Robert T., Savinov, Alexei, Serreze, David V., Leiter, Edward H.
Genetic analysis of autoimmune insulin-dependent diabetes mellitus (IDDM) has focused on genes controlling immune functions, with little investigation of innate susceptibility determinants expressed...
A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice
Farmer, Mark A., Sundberg, John P., Bristol, Ian J., Churchill, Gary A., Li, Renhua, Elson, Charles O., ...
Colitic lesions are much more severe in C3H/HeJBir (C3H) than C57BL/6J (B6) mice after 10 backcrosses of a disrupted interleukin-10 (Il10) gene. This study identified cytokine deficiency-induced...
Tracking autoimmune T cells in diabetes
Serreze, David V., Leiter, Edward H.
Insulin-dependent diabetes mellitus is usually caused by the autoimmune destruction of pancreatic β cells by T cells. Methodologies to track the development, migration, and functional activation of...
Maternal Environment and Genotype Interact to Establish Diabesity in Mice
Reifsnyder, Peter C., Churchill, Gary, Leiter, Edward H.
Obesity, a major risk factor for type II diabetes, is becoming more prevalent in Western populations consuming high calorie diets while expending less energy both at the workplace and at home. Most...
Insulin-dependent diabetes induced in susceptible strains of mice by multiple, low-dose streptozotocin treatment has been proposed to entail a thymus-dependent, autoimmune destruction of beta cells....
Absence of a reductase, NCB5OR, causes insulin-deficient diabetes
Xie, Jianxin, Zhu, Hao, Larade, Kevin, Ladoux, Annie, Seguritan, Ayden, Chu, Michelle, ...
NCB5OR is a highly conserved NAD(P)H reductase that contains a cytochrome b5-like domain at the N terminus and a cytochrome b5 reductase-like domain at the C terminus. The enzyme is located in the...
Mathews, Clayton E., Graser, Robert T., Savinov, Alexei, Serreze, David V., Leiter, Edward H.
Genetic analysis of autoimmune insulin-dependent diabetes mellitus (IDDM) has focused on genes controlling immune functions, with little investigation of innate susceptibility determinants expressed...
A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice
Farmer, Mark A., Sundberg, John P., Bristol, Ian J., Churchill, Gary A., Li, Renhua, Elson, Charles O., ...
Colitic lesions are much more severe in C3H/HeJBir (C3H) than C57BL/6J (B6) mice after 10 backcrosses of a disrupted interleukin-10 (Il10) gene. This study identified cytokine deficiency-induced...
Tracking autoimmune T cells in diabetes
Serreze, David V., Leiter, Edward H.
Insulin-dependent diabetes mellitus is usually caused by the autoimmune destruction of pancreatic β cells by T cells. Methodologies to track the development, migration, and functional activation of...
Maternal Environment and Genotype Interact to Establish Diabesity in Mice
Reifsnyder, Peter C., Churchill, Gary, Leiter, Edward H.
Obesity, a major risk factor for type II diabetes, is becoming more prevalent in Western populations consuming high calorie diets while expending less energy both at the workplace and at home. Most...
Insulin-dependent diabetes induced in susceptible strains of mice by multiple, low-dose streptozotocin treatment has been proposed to entail a thymus-dependent, autoimmune destruction of beta cells....
Absence of a reductase, NCB5OR, causes insulin-deficient diabetes
Xie, Jianxin, Zhu, Hao, Larade, Kevin, Ladoux, Annie, Seguritan, Ayden, Chu, Michelle, ...
NCB5OR is a highly conserved NAD(P)H reductase that contains a cytochrome b5-like domain at the N terminus and a cytochrome b5 reductase-like domain at the C terminus. The enzyme is located in the...
McInerney, Marcia F., Najjar, Sonia M., Brickley, Deanna, Lutzke, Mary, Abou-Rjaily, George A., Reifsnyder, Peter, ...
The New Zealand obese (NZO) mouse strain shares with the related New Zealand black (NZB) strain a number of immunophenotypic traits. Among these is a high proportion of B-1 B lymphocytes, a subset...