Edward P. O'Brien

Molecular origin of constant m-values, denatured state collapse, and residue-dependent transition midpoints in globular proteins (2009)

O'Brien, Edward P., Brooks, Bernard R., Thirumalai, Dave

Experiments show that for many two state folders the free energy of the native state DG_ND([C]) changes linearly as the denaturant concentration [C] is varied. The slope, m = d DG_ND([C])/d[C], is...

Effect of finite size on cooperativity and rates of protein folding (2006)

Kouza, Maksim, Li, Mai Suan, O'Brien Jr., Edward P., Hu, Chin-Kun, Thirumalai, D.

We analyze the dependence of cooperativity of the thermal denaturation transition and folding rates of globular proteins on the number of amino acid residues, $N$, using lattice models with side...

Ru2 and Ru encode mouse orthologs of the genes mutated in human Hermansky-Pudlak syndrome types 5 and 6 (2003)

Zhao, Baohui, Li, Wei, Oiso, Naoki, Novak, Edward K, Rusiniak, Michael E, ...

Hermansky-Pudlak syndrome (HPS) is a genetically heterogeneous disease involving abnormalities of melanosomes, platelet dense granules and lysosomes. Here we have used positional candidate and...

Effects of denaturants and osmolytes on proteins are accurately predicted by the molecular transfer model

O'Brien, Edward P., Ziv, Guy, Haran, Gilad, Brooks, Bernard R., Thirumalai, D.

Interactions between denaturants and proteins are commonly used to probe the structures of the denatured state ensemble and their stabilities. Osmolytes, a class of small intracellular organic...