Edward R. Whittemore

Nootropic α7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators

Ng, Herman J., Whittemore, Edward R., Tran, Minhtam B., Hogenkamp, Derk J., Broide, Ron S., Johnstone, Timothy B., ...

Activation of brain α7 nicotinic acetylcholine receptors (α7 nAChRs) has broad therapeutic potential in CNS diseases related to cognitive dysfunction, including Alzheimer's disease and...

V102862 (Co 102862): a potent, broad-spectrum state-dependent blocker of mammalian voltage-gated sodium channels

Ilyin, Victor I, Hodges, Dianne D, Whittemore, Edward R, Carter, Richard B, Cai, Sui Xiong, Woodward, Richard M

4-(4-Fluorophenoxy)benzaldehyde semicarbazone (V102862) was initially described as an orally active anticonvulsant with robust activity in a variety of rodent models of epilepsy. The mechanism of...