Zhang, Xiaohong, Ozawa, Yukiyasu, Lee, Heehyoung, Wen, Yu-Der, Tan, Tse-Hua, Wadzinski, Brian E., ...
Histone deacetylase 3 (HDAC3) is one of four members of the human class I HDACs that regulates gene expression by deacetylation of histones and nonhistone proteins. Early studies have suggested that...
McNeil, Sandra Marie, Guo, Bo, Stein, Janet L., Lian, Jane B., Bushmeyer, Sarah M., Seto, Edward, ...
The multifunctional transcription factor YY1 is associated with the nuclear matrix. In osteoblasts, the interaction of several nuclear matrix-associated transcription factors with the bone specific...
The histone deacetylase-3 complex contains nuclear receptor corepressors
Wen, Yu-Der, Perissi, Valentina, Staszewski, Lena M., Yang, Wen-Ming, Krones, Anna, Glass, Christopher K., ...
Acetylation and deacetylation of nucleosomal histones have profound effects on gene transcription in all eukaryotes. In humans, three highly homologous class I and four class II histone deacetylase...
Yang, Wen-Ming, Inouye, Carla, Zeng, Yingying, Bearss, David, Seto, Edward
YY1 is a mammalian zinc-finger transcription factor with unusual structural and functional features. It has been implicated as a positive and a negative regulatory factor that binds to the CCATNTT...
Tang, Chih-Min, Westling, Jennifer, Seto, Edward
Metallothioneins are small, highly conserved, cysteine-rich proteins that bind a variety of metal ions. They are found in virtually all eukaryotic organisms and are regulated primarily at the...
Lai, Albert, Lee, Joseph M., Yang, Wen-Ming, DeCaprio, James A., Kaelin, William G., Seto, Edward, ...
Retinoblastoma (RB) tumor suppressor family proteins block cell proliferation in part by repressing certain E2F-specific promoters. Both histone deacetylase (HDAC)-dependent and -independent...
Wu, Wen-Shu, Vallian, Sadeq, Seto, Edward, Yang, Wen-Ming, Edmondson, Diane, Roth, Sharon, ...
The growth suppressor promyelocytic leukemia protein (PML) is disrupted by the chromosomal translocation t(15;17) in acute promyelocytic leukemia (APL). PML plays a key role in multiple pathways of...
Lai, Albert, Kennedy, Brian K., Barbie, David A., Bertos, Nicholas R., Yang, Xiang Jiao, Theberge, Marie-Christine, ...
Retinoblastoma (RB) tumor suppressor family pocket proteins induce cell cycle arrest by repressing transcription of E2F-regulated genes through both histone deacetylase (HDAC)-dependent and...
Regulation of Transcription Factor YY1 by Acetylation and Deacetylation
Yao, Ya-Li, Yang, Wen-Ming, Seto, Edward
YY1 is a sequence-specific DNA-binding transcription factor that has many important biological roles. It activates or represses many genes during cell growth and differentiation and is also required...
Osborne, Aaron, Zhang, Hongquan, Yang, Wen-Ming, Seto, Edward, Blanck, George
Expression of the retinoblastoma tumor suppressor protein (Rb) is required for gamma interferon (IFN-γ)-inducible major histocompatibility complex class II gene expression and transcriptionally...
ETO, a Target of t(8;21) in Acute Leukemia, Interacts with the N-CoR and mSin3 Corepressors
Lutterbach, Bart, Westendorf, Jennifer J., Linggi, Bryan, Patten, Andrea, Moniwa, Mariko, Davie, James R., ...
t(8;21) is one of the most frequent translocations associated with acute myeloid leukemia. It produces a chimeric protein, acute myeloid leukemia-1 (AML-1)–eight-twenty-one (ETO), that contains the...
Yang, Wen-Ming, Yao, Ya-Li, Seto, Edward
FK506-binding proteins (FKBPs) are cellular receptors for immunosuppressants that belong to a subgroup of proteins, known as immunophilins, with peptidylprolyl cis–trans isomerase (PPIase)...
Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxβ
Tussié-Luna, María Isabel, Bayarsaihan, Dashzeveg, Seto, Edward, Ruddle, Frank H., Roy, Ananda L.
TFII-I family proteins are characterized structurally by the presence of multiple reiterated I-repeats, each containing a putative helix–loop–helix domain. Functionally, they behave as...
JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun
Weiss, Carsten, Schneider, Sandra, Wagner, Erwin F., Zhang, Xiaohong, Seto, Edward, Bohmann, Dirk
The AP-1 transcription factor c-Jun is a prototypical nuclear effector of the JNK signal transduction pathway. The integrity of JNK phosphorylation sites at serines 63/73 and at threonines 91/93 in...
Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1
Rezai-Zadeh, Natalie, Zhang, Xiaohong, Namour, Fares, Fejer, Gyorgy, Wen, Yu-Der, Yao, Ya-Li, ...
Methylation of specific residues within the N-terminal histone tails plays a critical role in regulating eukaryotic gene expression. Although great advances have been made toward identifying histone...
Negative Regulation of Histone Deacetylase 8 Activity by Cyclic AMP-Dependent Protein Kinase A
Lee, Heehyoung, Rezai-Zadeh, Natalie, Seto, Edward
Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl groups from lysine residues of histone and nonhistone proteins. Recent studies suggest that they are key regulators of...
Zhang, Xiaohong, Wharton, Walker, Yuan, Zhigang, Tsai, Shih-Chang, Olashaw, Nancy, Seto, Edward
Histone deacetylase (HDAC) inhibitors inhibit the proliferation of transformed cells in vitro, restrain tumor growth in animals, and are currently being actively exploited as potential anticancer...
Zhang, Xiaohong, Ozawa, Yukiyasu, Lee, Heehyoung, Wen, Yu-Der, Tan, Tse-Hua, Wadzinski, Brian E., ...
Histone deacetylase 3 (HDAC3) is one of four members of the human class I HDACs that regulates gene expression by deacetylation of histones and nonhistone proteins. Early studies have suggested that...
Baumeister, Peter, Luo, Shengzhan, Skarnes, William C., Sui, Guangchao, Seto, Edward, Shi, Yang, ...
The unfolded protein response is an evolutionarily conserved mechanism whereby cells respond to stress conditions that target the endoplasmic reticulum (ER). The transcriptional activation of the...
COACTIVATORS AND COREPRESSORS OF NF-KB IN IkB ALPHA GENE PROMOTER
Gao, Zhanguo, Chiao, Paul, Zhang, Xia, Zhang, Xiaohong, Lazar, Mitchell, Seto, Edward, ...
In this study, we investigated recruitment of coactivators (SRC-1, SRC-2 and SRC-3) and corepressors (HDAC1, HDAC2, HDAC3, SMRT and NCoR) to the IkBα gene promoter after NF-kB activation by TNF-α....
Lee, Heehyoung, Sengupta, Nilanjan, Villagra, Alejandro, Rezai-Zadeh, Natalie, Seto, Edward
Histone deacetylases (HDACs) are enzymes that regulate the functions of histones as well as nonhistones by catalyzing the removal of acetyl groups from lysine residues. HDACs regulate many biological...
The histone deacetylase-3 complex contains nuclear receptor corepressors
Wen, Yu-Der, Perissi, Valentina, Staszewski, Lena M., Yang, Wen-Ming, Krones, Anna, Glass, Christopher K., ...
Acetylation and deacetylation of nucleosomal histones have profound effects on gene transcription in all eukaryotes. In humans, three highly homologous class I and four class II histone deacetylase...
Yang, Wen-Ming, Inouye, Carla, Zeng, Yingying, Bearss, David, Seto, Edward
YY1 is a mammalian zinc-finger transcription factor with unusual structural and functional features. It has been implicated as a positive and a negative regulatory factor that binds to the CCATNTT...
Tang, Chih-Min, Westling, Jennifer, Seto, Edward
Metallothioneins are small, highly conserved, cysteine-rich proteins that bind a variety of metal ions. They are found in virtually all eukaryotic organisms and are regulated primarily at the...
Lai, Albert, Lee, Joseph M., Yang, Wen-Ming, DeCaprio, James A., Kaelin, William G., Seto, Edward, ...
Retinoblastoma (RB) tumor suppressor family proteins block cell proliferation in part by repressing certain E2F-specific promoters. Both histone deacetylase (HDAC)-dependent and -independent...
Wu, Wen-Shu, Vallian, Sadeq, Seto, Edward, Yang, Wen-Ming, Edmondson, Diane, Roth, Sharon, ...
The growth suppressor promyelocytic leukemia protein (PML) is disrupted by the chromosomal translocation t(15;17) in acute promyelocytic leukemia (APL). PML plays a key role in multiple pathways of...
Lai, Albert, Kennedy, Brian K., Barbie, David A., Bertos, Nicholas R., Yang, Xiang Jiao, Theberge, Marie-Christine, ...
Retinoblastoma (RB) tumor suppressor family pocket proteins induce cell cycle arrest by repressing transcription of E2F-regulated genes through both histone deacetylase (HDAC)-dependent and...
Regulation of Transcription Factor YY1 by Acetylation and Deacetylation
Yao, Ya-Li, Yang, Wen-Ming, Seto, Edward
YY1 is a sequence-specific DNA-binding transcription factor that has many important biological roles. It activates or represses many genes during cell growth and differentiation and is also required...
Osborne, Aaron, Zhang, Hongquan, Yang, Wen-Ming, Seto, Edward, Blanck, George
Expression of the retinoblastoma tumor suppressor protein (Rb) is required for gamma interferon (IFN-γ)-inducible major histocompatibility complex class II gene expression and transcriptionally...
ETO, a Target of t(8;21) in Acute Leukemia, Interacts with the N-CoR and mSin3 Corepressors
Lutterbach, Bart, Westendorf, Jennifer J., Linggi, Bryan, Patten, Andrea, Moniwa, Mariko, Davie, James R., ...
t(8;21) is one of the most frequent translocations associated with acute myeloid leukemia. It produces a chimeric protein, acute myeloid leukemia-1 (AML-1)–eight-twenty-one (ETO), that contains the...
Yang, Wen-Ming, Yao, Ya-Li, Seto, Edward
FK506-binding proteins (FKBPs) are cellular receptors for immunosuppressants that belong to a subgroup of proteins, known as immunophilins, with peptidylprolyl cis–trans isomerase (PPIase)...
Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxβ
Tussié-Luna, María Isabel, Bayarsaihan, Dashzeveg, Seto, Edward, Ruddle, Frank H., Roy, Ananda L.
TFII-I family proteins are characterized structurally by the presence of multiple reiterated I-repeats, each containing a putative helix–loop–helix domain. Functionally, they behave as...
JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun
Weiss, Carsten, Schneider, Sandra, Wagner, Erwin F., Zhang, Xiaohong, Seto, Edward, Bohmann, Dirk
The AP-1 transcription factor c-Jun is a prototypical nuclear effector of the JNK signal transduction pathway. The integrity of JNK phosphorylation sites at serines 63/73 and at threonines 91/93 in...
Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1
Rezai-Zadeh, Natalie, Zhang, Xiaohong, Namour, Fares, Fejer, Gyorgy, Wen, Yu-Der, Yao, Ya-Li, ...
Methylation of specific residues within the N-terminal histone tails plays a critical role in regulating eukaryotic gene expression. Although great advances have been made toward identifying histone...
Negative Regulation of Histone Deacetylase 8 Activity by Cyclic AMP-Dependent Protein Kinase A
Lee, Heehyoung, Rezai-Zadeh, Natalie, Seto, Edward
Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl groups from lysine residues of histone and nonhistone proteins. Recent studies suggest that they are key regulators of...
Zhang, Xiaohong, Wharton, Walker, Yuan, Zhigang, Tsai, Shih-Chang, Olashaw, Nancy, Seto, Edward
Histone deacetylase (HDAC) inhibitors inhibit the proliferation of transformed cells in vitro, restrain tumor growth in animals, and are currently being actively exploited as potential anticancer...
Zhang, Xiaohong, Ozawa, Yukiyasu, Lee, Heehyoung, Wen, Yu-Der, Tan, Tse-Hua, Wadzinski, Brian E., ...
Histone deacetylase 3 (HDAC3) is one of four members of the human class I HDACs that regulates gene expression by deacetylation of histones and nonhistone proteins. Early studies have suggested that...
Baumeister, Peter, Luo, Shengzhan, Skarnes, William C., Sui, Guangchao, Seto, Edward, Shi, Yang, ...
The unfolded protein response is an evolutionarily conserved mechanism whereby cells respond to stress conditions that target the endoplasmic reticulum (ER). The transcriptional activation of the...
Lee, Heehyoung, Sengupta, Nilanjan, Villagra, Alejandro, Rezai-Zadeh, Natalie, Seto, Edward
Histone deacetylases (HDACs) are enzymes that regulate the functions of histones as well as nonhistones by catalyzing the removal of acetyl groups from lysine residues. HDACs regulate many biological...
Histone Deacetylase 3 Interacts with and Deacetylates Myocyte Enhancer Factor 2▿ †
Grégoire, Serge, Xiao, Lin, Nie, Jianyun, Zhang, Xiaohong, Xu, Minghong, Li, Jiarong, ...
The myocyte enhancer factor 2 (MEF2) family of transcription factors is not only important for controlling gene expression in normal cellular programs, like muscle differentiation, T-cell apoptosis,...