Edwin P. Alyea

Corresponding Author: (2005)

Roberto Bellucci, Edwin P Alyea, Sabina Chiaretti, Catherine J Wu, Emmanuel Zorn, Edie Weller, ...

doi:10.1182/blood-2004-11-4463 Graft versus tumor response in patients with multiple myeloma is associated with antibody response to BCMA, a plasma cell membrane receptor

CML66, a broadly immunogenic tumor antigen, elicits a humoral immune response associated with remission of chronic myelogenous leukemia

Yang, Xiao-Feng, Wu, Catherine J., McLaughlin, Stephen, Chillemi, Antoinette, Wang, Kathy S., Canning, Christine, ...

This report describes a tumor-associated antigen, termed CML66, initially cloned from a chronic myelogenous leukemia (CML) cDNA expression library. CML66 encodes a 583-aa protein with a molecular...

ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction

Hodi, F. Stephen, Schmollinger, Jan C., Soiffer, Robert J., Salgia, Ravi, Lynch, Thomas, Ritz, Jerome, ...

An important goal of cancer immunology is the identification of antigens associated with tumor destruction. Vaccination with irradiated tumor cells engineered to secrete granulocyte/macrophage...

Detection of a potent humoral response associated with immune-induced remission of chronic myelogenous leukemia

Wu, Catherine J., Yang, Xiao-Feng, McLaughlin, Stephen, Neuberg, Donna, Canning, Christine, Stein, Brady, ...

The effectiveness of donor-lymphocyte infusion (DLI) for treatment of relapsed chronic myelogenous leukemia (CML) after allogeneic bone marrow transplantation is a clear demonstration of the...

Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission

Miklos, David B., Kim, Haesook T., Miller, Katherine H., Guo, Luxuan, Zorn, Emmanuel, Lee, Stephanie J., ...

Minor histocompatibility antigens (mHAs) are known targets of donor T cells after allogeneic hematopoietic stem cell transplantation (HSCT). In contrast, B-cell responses to mHAs have not been...

Emergence of a Clinical Daptomycin-Resistant Staphylococcus aureus Isolate during Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia and Osteomyelitis

Marty, Francisco M., Yeh, Wendy W., Wennersten, Christine B., Venkataraman, Lata, Albano, Esperanza, Alyea, Edwin P., ...

The emergence of a clinically daptomycin-resistant Staphylococcus aureus isolate occurred during treatment of methicillin-resistant S. aureus bacteremia and probable vertebral osteomyelitis. The...

CML66, a broadly immunogenic tumor antigen, elicits a humoral immune response associated with remission of chronic myelogenous leukemia

Yang, Xiao-Feng, Wu, Catherine J., McLaughlin, Stephen, Chillemi, Antoinette, Wang, Kathy S., Canning, Christine, ...

This report describes a tumor-associated antigen, termed CML66, initially cloned from a chronic myelogenous leukemia (CML) cDNA expression library. CML66 encodes a 583-aa protein with a molecular...

ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction

Hodi, F. Stephen, Schmollinger, Jan C., Soiffer, Robert J., Salgia, Ravi, Lynch, Thomas, Ritz, Jerome, ...

An important goal of cancer immunology is the identification of antigens associated with tumor destruction. Vaccination with irradiated tumor cells engineered to secrete granulocyte/macrophage...

Detection of a potent humoral response associated with immune-induced remission of chronic myelogenous leukemia

Wu, Catherine J., Yang, Xiao-Feng, McLaughlin, Stephen, Neuberg, Donna, Canning, Christine, Stein, Brady, ...

The effectiveness of donor-lymphocyte infusion (DLI) for treatment of relapsed chronic myelogenous leukemia (CML) after allogeneic bone marrow transplantation is a clear demonstration of the...

Emergence of a Clinical Daptomycin-Resistant Staphylococcus aureus Isolate during Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia and Osteomyelitis

Marty, Francisco M., Yeh, Wendy W., Wennersten, Christine B., Venkataraman, Lata, Albano, Esperanza, Alyea, Edwin P., ...

The emergence of a clinically daptomycin-resistant Staphylococcus aureus isolate occurred during treatment of methicillin-resistant S. aureus bacteremia and probable vertebral osteomyelitis. The...

Graft-versus-tumor response in patients with multiple myeloma is associated with antibody response to BCMA, a plasma-cell membrane receptor

Bellucci, Roberto, Alyea, Edwin P., Chiaretti, Sabina, Wu, Catherine J., Zorn, Emmanuel, Weller, Edie, ...

Donor lymphocyte infusions (DLIs) induce effective graft-versus-tumor responses in patients with multiple myeloma who relapse after allogeneic hematopoietic stem-cell transplantation. The...

Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia

Gribben, John G., Zahrieh, David, Stephans, Katherine, Bartlett-Pandite, Lini, Alyea, Edwin P., Fisher, David C., ...

We report here on the long-term follow-up on 162 patients with high-risk chronic lymphocytic leukemia (CLL) who have undergone hematopoietic stem cell transplantation (SCT) at a single center from...

Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host disease

Zorn, Emmanuel, Kim, Haesook T., Lee, Stephanie J., Floyd, Blair H., Litsa, Despina, Arumugarajah, Sankari, ...

Chronic graft-versus-host disease (cGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation but the immune mechanisms leading to the diverse clinical manifestations of...

Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis

Bellucci, Roberto, Oertelt, Sabine, Gallagher, Meagan, Li, Sigui, Zorn, Emmanuel, Weller, Edie, ...

A unique characteristic of the autoimmune liver disease primary biliary cirrhosis (PBC) is the presence of high-titer and extremely specific autoantibodies to the E2 component of the pyruvate...

Prognostic impact of elevated pretransplantation serum ferritin in patients undergoing myeloablative stem cell transplantation

Armand, Philippe, Kim, Haesook T., Cutler, Corey S., Ho, Vincent T., Koreth, John, Alyea, Edwin P., ...

Iron overload could be a significant contributor to treatment-related mortality (TRM) for patients with hematologic malignancies undergoing hematopoietic stem cell transplantation (HSCT). We studied...

Sirolimus-based graft-versus-host disease prophylaxis protects against cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation: a cohort analysis

Marty, Francisco M., Bryar, Julie, Browne, Sarah K., Schwarzberg, Talya, Ho, Vincent T., Bassett, Ingrid V., ...

Sirolimus-based immunosuppressive regimens in organ transplantation have been associated with a lower than expected incidence of cytomegalovirus (CMV) disease. Whether sirolimus has a similar effect...