Schoenemeyer, Annett, Barnes, Betsy J., Mancl, Margo E., Latz, Eicke, Goutagny, Nadege, Pitha, Paula M., ...
Interferon regulatory factors (IRFs) are critical components of virus-induced immune activation and type I interferon regulation. IRF3 and IRF7 are activated in response to a variety of viruses or...
Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling (2003)
Sandor, Frantisek, Latz, Eicke, Re, Fabio, Mandell, Leisa, Repik, Galina, Golenbock, Douglas, ...
Recognition of ligands by toll-like receptor (TLR) 2 requires interactions with other TLRs. TLRs form a combinatorial repertoire to discriminate between the diverse microbial ligands. Diversity...
Visintin, Alberto, Latz, Eicke, Monks, Brian G., Espevik, Terje, Golenbock, Douglas
Three cell-surface proteins have been recognized as components of the mammalian signaling receptor for bacterial lipopolysaccharide (LPS): CD14, Toll-like receptor-4 (TLR4), and MD-2. Biochemical and...
Latz, Eicke, Visintin, Alberto, Lien, Egil, Fitzgerald, Kate A., Monks, Brian G., Kurt-Jones, Evelyn A., ...
Mammalian responses to LPS require the expression of Toll-like receptor 4 (TLR4), CD14, and MD-2. We expressed fluorescent TLR4 in cell lines and found that TLR4 densely localized to the surface and...
Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2
Compton, Teresa, Kurt-Jones, Evelyn A., Boehme, Karl W., Belko, John, Latz, Eicke, Golenbock, Douglas T., ...
Human cytomegalovirus (CMV) is a ubiquitous opportunistic pathogen that causes significant morbidity and mortality in immuncompromised people. An understanding of how CMV induces and circumvents host...
Receptor “cross talk” in innate immunity
Latz, Eicke, Golenbock, Douglas T.
Toll-like receptors (TLRs) recognize microbial molecular signatures and can initiate innate immune responses against invading pathogens. A new study reports how TLR2 expression by endothelia is...
Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9
Means, Terry K., Latz, Eicke, Hayashi, Fumitaka, Murali, Mandakolathur R., Golenbock, Douglas T., Luster, Andrew D.
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by pathogenic autoantibodies against nucleoproteins and DNA. Here we show that DNA-containing immune complexes (ICs) within...
Comparative Toll-Like Receptor 4-Mediated Innate Host Defense to Bordetella Infection
Mann, Paul B., Wolfe, Daniel, Latz, Eicke, Golenbock, Douglas, Preston, Andrew, Harvill, Eric T.
Bordetella pertussis, B. parapertussis, and B. bronchiseptica are closely related species associated with respiratory disease in humans and other mammals. While B. bronchiseptica has a wide host...
Rowe, Daniel C., McGettrick, Anne F., Latz, Eicke, Monks, Brian G., Gay, Nicholas J., Yamamoto, Masahiro, ...
TRIF-related adaptor molecule (TRAM) is the fourth Toll/IL-1 resistance domain-containing adaptor to be described that participates in Toll-like receptor (TLR) signaling. TRAM functions exclusively...
Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2
Compton, Teresa, Kurt-Jones, Evelyn A., Boehme, Karl W., Belko, John, Latz, Eicke, Golenbock, Douglas T., ...
Human cytomegalovirus (CMV) is a ubiquitous opportunistic pathogen that causes significant morbidity and mortality in immuncompromised people. An understanding of how CMV induces and circumvents host...
Receptor “cross talk” in innate immunity
Latz, Eicke, Golenbock, Douglas T.
Toll-like receptors (TLRs) recognize microbial molecular signatures and can initiate innate immune responses against invading pathogens. A new study reports how TLR2 expression by endothelia is...
Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9
Means, Terry K., Latz, Eicke, Hayashi, Fumitaka, Murali, Mandakolathur R., Golenbock, Douglas T., Luster, Andrew D.
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by pathogenic autoantibodies against nucleoproteins and DNA. Here we show that DNA-containing immune complexes (ICs) within...
Comparative Toll-Like Receptor 4-Mediated Innate Host Defense to Bordetella Infection
Mann, Paul B., Wolfe, Daniel, Latz, Eicke, Golenbock, Douglas, Preston, Andrew, Harvill, Eric T.
Bordetella pertussis, B. parapertussis, and B. bronchiseptica are closely related species associated with respiratory disease in humans and other mammals. While B. bronchiseptica has a wide host...
Rowe, Daniel C., McGettrick, Anne F., Latz, Eicke, Monks, Brian G., Gay, Nicholas J., Yamamoto, Masahiro, ...
TRIF-related adaptor molecule (TRAM) is the fourth Toll/IL-1 resistance domain-containing adaptor to be described that participates in Toll-like receptor (TLR) signaling. TRAM functions exclusively...
Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity
Husebye, Harald, Halaas, Øyvind, Stenmark, Harald, Tunheim, Gro, Sandanger, Øystein, Bogen, Bjarne, ...
Immune responses are initiated when molecules of microbial origin are sensed by the Toll-like receptors (TLRs). We now report the identification of essential molecular components for the trafficking...
Parroche, Peggy, Lauw, Fanny N., Goutagny, Nadege, Latz, Eicke, Monks, Brian G., Visintin, Alberto, ...
Hemozoin (HZ) is an insoluble crystal formed in the food vacuole of malaria parasites. HZ has been reported to induce inflammation by directly engaging Toll-like receptor (TLR) 9, an endosomal...
LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF
Fitzgerald, Katherine A., Rowe, Daniel C., Barnes, Betsy J., Caffrey, Daniel R., Visintin, Alberto, Latz, Eicke, ...
Toll–IL-1–resistance (TIR) domain–containing adaptor-inducing IFN-β (TRIF)–related adaptor molecule (TRAM) is the fourth TIR domain–containing adaptor protein to be described that...
Schromm, Andra B., Lien, Egil, Henneke, Philipp, Chow, Jesse C., Yoshimura, Atsutoshi, Heine, Holger, ...
Somatic cell mutagenesis is a powerful tool for characterizing receptor systems. We reported previously two complementation groups of mutant cell lines derived from CD14-transfected Chinese hamster...
Importance of extra- and intracellular domains of TLR1 and TLR2 in NFκB signaling
Sandor, Frantisek, Latz, Eicke, Re, Fabio, Mandell, Leisa, Repik, Galina, Golenbock, Douglas T., ...
Recognition of ligands by toll-like receptor (TLR) 2 requires interactions with other TLRs. TLRs form a combinatorial repertoire to discriminate between the diverse microbial ligands. Diversity...