Elias Hobeika

Yin Yang 1 is a critical regulator of B-cell development (2007)

Liu, Huifei, Schmidt-Supprian, Marc, Shi, Yujiang, Hobeika, Elias, Barteneva, Natasha, Jumaa, Hassan, ...

The role of the transcription factor Yin Yang 1 (YY1) in development is largely unknown. Here we show that specific ablation of YY1 in mouse B cells caused a defect in somatic rearrangement in the...

Analysis of the imb-1 mouse strain with an inducible B-cell system / (2005)

Hobeika, Elias.

Freiburg (Breisgau), Univ., Diss., 2004 (Nur beschränkt für den Austausch).

Yin Yang 1 is a critical regulator of B-cell development

Liu, Huifei, Schmidt-Supprian, Marc, Shi, Yujiang, Hobeika, Elias, Barteneva, Natasha, Jumaa, Hassan, ...

The role of the transcription factor Yin Yang 1 (YY1) in development is largely unknown. Here we show that specific ablation of YY1 in mouse B cells caused a defect in somatic rearrangement in the...

Identification of a Pre-BCR Lacking Surrogate Light Chain

Su, Yu-wen, Flemming, Alexandra, Wossning, Thomas, Hobeika, Elias, Reth, Michael, Jumaa, Hassan

SLP-65−/− pre-B cells show a high proliferation rate in vitro. We have shown previously that λ5 expression and consequently a conventional pre-B cell receptor (pre-BCR) are essential for this...

The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development

Kulathu, Yogesh, Hobeika, Elias, Turchinovich, Gleb, Reth, Michael

Upon B-cell antigen receptor (BCR) activation, the protein tyrosine kinase Syk phosphorylates the adaptor protein SH2 domain-containing leukocyte protein of 65 kDa (SLP-65), thus coupling the BCR to...