Eliette Touati

Organ-targeted mutagenicity of nitrofurantoin in Big Blue transgenic mice (2006)

Quillardet, Philippe, Arrault, Xavier, Michel, Valérie, Touati, Eliette

Nitrofurans are widely used in human medicine, as nitrofurantoin and nifuroxazide, still prescribed for long-term antimicrobial prophylaxis of urinary tract and gastrointestinal infection in humans...

Organ-targeted mutagenicity of nitrofurantoin in Big Blue transgenic mice (2006)

Quillardet, Philippe, Arrault, Xavier, Michel, Valérie, Touati, Eliette

Nitrofurans are widely used in human medicine, as nitrofurantoin and nifuroxazide, still prescribed for long-term antimicrobial prophylaxis of urinary tract and gastrointestinal infection in humans...

Comparison of kinetics of induction of DNA adducts and gene mutations by a nitrofuran compound, 7-methoxy-2-nitronaphtho[2,1-b]furan (R7000), in the caecum and small intestine of Big BlueTM mice (2002)

Arrault, Xavier, Michel, Valérie, Quillardet, Philippe, Hofnung, Maurice, Touati, Eliette

In previous experiments, i.p. injection of the 5 nitronaphthofuran derivative 7-methoxy-2-nitronaphtho[2,1-b]furan (R7000) to lacI transgenic Big Blue™ mice led to an increase in the...

Short-term infection with Helicobacter pylori and 1 week exposure to metronidazole does not enhance gastric mutation frequency in transgenic mice (2000)

Touati, Eliette, Hofnung, Maurice, Thiberge, Jean-Michel, Michel, Valérie, Labigne, Agnès, Jenks, Peter J.

The aim of this study was to determine whether exposure of Helicobacter pylori-infected mice to metronidazole resulted in the delivery of mutagenic compounds to the gastric epithelium via the...

7-Methoxy-2-nitronaphtho(2, l-b)furan (R7000)-induced mutation spectrum in the lacI gene of Escherichia coli: influence of SOS mutagenesis (1996)

Touati, Eliette, Krin, Evelyne, Quillardet, Philippe, Hofnung, Maurice

The mutagenic specificity of 7-methoxy-2-nitronaphtho(2, l-b)furan (R7000), a very potent genotoxie 2-nitrofuran, was investigated in the lacl gene of E.coli. To analyze the influence of...