Peng, Yong, Murray, Elizabeth L., Sarkar, Madhubanti, Liu, Xiaoqiang, Schoenberg, Daniel R.
The PMR1 mRNA endonuclease catalyzes the selective decay of a limited number of mRNAs. It participates in multiple complexes, including one containing c-Src, its activating kinase, and one containing...
PENG, JING, MURRAY, ELIZABETH L., SCHOENBERG, DANIEL R.
The poly(A)-limiting element (PLE) is a conserved sequence originally found in the 3′ UTR of Xenopus albumin mRNA whose presence restricts the length of the poly(A) tail on both pre-mRNA and fully...
PENG, JING, MURRAY, ELIZABETH L., SCHOENBERG, DANIEL R.
The poly(A)-limiting element (PLE) is a conserved sequence originally found in the 3′ UTR of Xenopus albumin mRNA whose presence restricts the length of the poly(A) tail on both pre-mRNA and fully...
Multiple Regulators Control Expression of the Entner-Doudoroff Aldolase (Eda) of Escherichia coli
Murray, Elizabeth L., Conway, Tyrrell
The Escherichia coli eda gene, which encodes the Entner-Doudoroff aldolase, is central to the catabolism of several sugar acids. Here, we show that Eda synthesis is induced by growth on gluconate,...
PENG, JING, MURRAY, ELIZABETH L., SCHOENBERG, DANIEL R.
The poly(A)-limiting element (PLE) is a conserved sequence originally found in the 3′ UTR of Xenopus albumin mRNA whose presence restricts the length of the poly(A) tail on both pre-mRNA and fully...
Multiple Regulators Control Expression of the Entner-Doudoroff Aldolase (Eda) of Escherichia coli
Murray, Elizabeth L., Conway, Tyrrell
The Escherichia coli eda gene, which encodes the Entner-Doudoroff aldolase, is central to the catabolism of several sugar acids. Here, we show that Eda synthesis is induced by growth on gluconate,...
PENG, JING, MURRAY, ELIZABETH L., SCHOENBERG, DANIEL R.
The poly(A)-limiting element (PLE) is a conserved sequence originally found in the 3′ UTR of Xenopus albumin mRNA whose presence restricts the length of the poly(A) tail on both pre-mRNA and fully...
Yang, Feng, Peng, Yong, Murray, Elizabeth L., Otsuka, Yuichi, Kedersha, Nancy, Schoenberg, Daniel R.
The generalized process of mRNA decay involves deadenylation followed by release from translating polysomes, decapping, and exonuclease decay of the mRNA body. In contrast the mRNA endonuclease PMR1...
A+U-Rich Instability Elements Differentially Activate 5′-3′ and 3′-5′ mRNA Decay▿
Murray, Elizabeth L., Schoenberg, Daniel R.
The A+U-rich elements (or AREs) are cis-acting sequences that activate rapid mRNA decay, yet the overall polarity of this process is unknown. The current study describes an unbiased approach to this...
A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay
Ferraiuolo, Maria A., Basak, Sanjukta, Dostie, Josee, Murray, Elizabeth L., Schoenberg, Daniel R., Sonenberg, Nahum
4E-transporter (4E-T) is one of several proteins that bind the mRNA 5′cap-binding protein, eukaryotic initiation factor 4E (eIF4E), through a conserved binding motif. We previously showed that 4E-T...
Jazdzewski, Krystian, Murray, Elizabeth L., Franssila, Kaarle, Jarzab, Barbara, Schoenberg, Daniel R., De La Chapelle, Albert
Although papillary thyroid carcinoma (PTC) displays strong heritability, no predisposing germ-line mutations have been found. We show that a common G/C polymorphism (rs2910164) within the...
Peng, Yong, Murray, Elizabeth L., Sarkar, Madhubanti, Liu, Xiaoqiang, Schoenberg, Daniel R.
The PMR1 mRNA endonuclease catalyzes the selective decay of a limited number of mRNAs. It participates in multiple complexes, including one containing c-Src, its activating kinase, and one containing...