Modulierung der NF-KB-Aktivität in T-Zellen durch den Carmal1-Bcl10-Malt1 Komplex (2006)
Das Schicksal aktivierter T-Zellen wird durch eine Vielzahl NF-kappaB regulierter Ziel-Gene bestimmt, wobei aktivierende und deaktivierende Signale für die Ausbalancierung einer adäquaten T-Zell...
Modulierung der NF-KB-Aktivität in T-Zellen durch den Carmal1-Bcl10-Malt1 Komplex (2006)
Das Schicksal aktivierter T-Zellen wird durch eine Vielzahl NF-kappaB regulierter Ziel-Gene bestimmt, wobei aktivierende und deaktivierende Signale für die Ausbalancierung einer adäquaten T-Zell...
Degradation of Bcl10 Induced by T-Cell Activation Negatively Regulates NF-κB Signaling
Scharschmidt, Erika, Wegener, Elmar, Heissmeyer, Vigo, Rao, Anjana, Krappmann, Daniel
Bcl10 is a critical regulator of NF-κB activity in T and B cells, coupling antigen receptor signaling to NF-κB activation via protein kinase C (PKC). Here we show that PKC or T-cell receptor...
Krappmann, Daniel, Wegener, Elmar, Sunami, Yoshiaki, Esen, Meral, Thiel, Andreas, Mordmuller, Benjamin, ...
Toll-like receptors (TLRs) recognize conserved products of microbial pathogens to initiate the innate immune response. TLR4 signaling is triggered upon binding of lipopolysaccharides (LPS) from...
Lymphotoxin and lipopolysaccharide induce NF-κB-p52 generation by a co-translational mechanism
Mordmüller, Benjamin, Krappmann, Daniel, Esen, Meral, Wegener, Elmar, Scheidereit, Claus
The 'classical' NF-κB activation pathway proceeds via IκB kinase (IKK)-β/γ-mediated phosphorylation, induced ubiquitination and the degradation of small IκBs. An alternative, NF-κB-inducing...
Degradation of Bcl10 Induced by T-Cell Activation Negatively Regulates NF-κB Signaling
Scharschmidt, Erika, Wegener, Elmar, Heissmeyer, Vigo, Rao, Anjana, Krappmann, Daniel
Bcl10 is a critical regulator of NF-κB activity in T and B cells, coupling antigen receptor signaling to NF-κB activation via protein kinase C (PKC). Here we show that PKC or T-cell receptor...
Krappmann, Daniel, Wegener, Elmar, Sunami, Yoshiaki, Esen, Meral, Thiel, Andreas, Mordmuller, Benjamin, ...
Toll-like receptors (TLRs) recognize conserved products of microbial pathogens to initiate the innate immune response. TLR4 signaling is triggered upon binding of lipopolysaccharides (LPS) from...
Lymphotoxin and lipopolysaccharide induce NF-κB-p52 generation by a co-translational mechanism
Mordmüller, Benjamin, Krappmann, Daniel, Esen, Meral, Wegener, Elmar, Scheidereit, Claus
The 'classical' NF-κB activation pathway proceeds via IκB kinase (IKK)-β/γ-mediated phosphorylation, induced ubiquitination and the degradation of small IκBs. An alternative, NF-κB-inducing...
Malt1 ubiquitination triggers NF-κB signaling upon T-cell activation
Oeckinghaus, Andrea, Wegener, Elmar, Welteke, Verena, Ferch, Uta, Arslan, Seda Çöl, Ruland, Jürgen, ...
Triggering of antigen receptors on lymphocytes is critical for initiating adaptive immune response against pathogens. T-cell receptor (TCR) engagement induces the formation of the...