Tahara, Hideaki, Sato, Marimo, Thurin, Magdalena, Wang, Ena, Butterfield, Lisa H, Disis, Mary L, ...
Abstract Supported by the Office of International Affairs, National Cancer Institute (NCI), the " US-Japan Workshop on Immunological Biomarkers in Oncology " was held in March 2009. The workshop was...
Toward a Systems Biology Software Toolkit (2009)
Donald J. Johann, Michael D. Mcguigan, Stanmire Tomov, Eric Blum, R. Whiteley, Emanuel F. Petricoin, ...
Insight to complex problems may be revealed when domain data sets are viewed or structured in new and innovative ways. Systems approaches to biomedical problems fundamentally involve forecasting, and...
A Serum Proteomic Approach to Gauging the State of Remission in Wegener’s Granulomatosis (2009)
John H. Stone, Vinodh N. Rajapakse, Gary S. Hoffman, Ulrich Specks, Peter A. Merkel, Robert F. Spiera, ...
for the Wegener’s Granulomatosis Etanercept Trial (WGET) Research Group Objective. To identify serum ion patterns that distinguish remission from active disease in patients with Wegener’s...
Weida Tong, Qian Xie, Huixiao Hong, Hong Fang, Leming Shi, Roger Perkins, ...
Class prediction using “omics ” data is playing an increasing role in toxicogenomics, diagnosis/prognosis, and risk assessment. These data are usually noisy and represented by relatively few...
BIOINFORMATICS Analysis of Mass Spectral Serum Profiles for Biomarker Selection (2008)
Habtom W. Ressom, Rency S. Varghese, Mohamed Abdel-hamid, Sohair Abdel-latif, Daniel Saha, Lenka Goldman, ...
Motivation: Mass spectrometric profiles of peptides and proteins obtained by current technologies are characterized by complex spectra, high dimensionality, and substantial noise. These...
Charge Transport Phenomena in Peptide Molecular Junctions (2008)
Alessandra Luchini, David P. Long, Iosif I. Vaisman, Emanuel F. Petricoin, David H. Geho, Lance A. Liotta
Inelastic electron tunneling spectroscopy (IETS) is a valuable in situ spectroscopic analysis technique that provides a direct portrait of the electron transport properties of a molecular species. In...
Proteomics Discovery of Disease Biomarkers (2008)
Mamoun Ahram, Emanuel F. Petricoin
Recent technological developments in proteomics have shown promising initiatives in identifying novel biomarkers of various diseases. Such technologies are capable of investigating multiple samples...
Charge Transport Phenomena in Peptide Molecular Junctions (2008)
Alessandra Luchini, David P. Long, Iosif I. Vaisman, Emanuel F. Petricoin, David H. Geho, Lance A. Liotta
Inelastic electron tunneling spectroscopy (IETS) is a valuable in situ spectroscopic analysis technique that provides a direct portrait of the electron transport properties of a molecular species. In...
Charboneau, Lu, Tory, Heather, Chen, Tina, Winters, Mary, Petricoin, Emanuel F., Liotta, Lance A., ...
Analysis of mass spectral serum profiles for biomarker selection (2005)
Habtom W. Ressom, Rency S. Varghese, Mohamed Abdel-hamid, Daniel Saha, Lenka Goldman, ...
doi:10.1093/bioinformatics/bti670
Liotta, Lance A., Lowenthal, Mark, Mehta, Arpita, Conrads, Thomas P., Veenstra, Timothy D., Fishman, David A., ...
The application of mass spectrometry to discover new cancer biomarkers is in its infancy. Many of these new markers are low-abundance proteins that exist as fragments associated with carrier...
Analysis of mass spectral serum profiles for biomarker selection (2005)
Ressom, Habtom W., Varghese, Rency S., Abdel-Hamid, Mohamed, Saha, Daniel, Goldman, Lenka, ...
Motivation: Mass spectrometric profiles of peptides and proteins obtained by current technologies are characterized by complex spectra, high dimensionality, and substantial noise. These...
Analysis of mass spectral serum profiles for biomarker selection (2005)
Ressom, Habtom W., Varghese, Rency S., Abdel-Hamid, Mohamed, Eissa, Sohair Abdel-Latif, Saha, Daniel, Goldman, Lenka, ...
Motivation: Mass spectrometric profiles of peptides and proteins obtained by current technologies are characterized by complex spectra, high dimensionality and substantial noise. These...
Charboneau, Lu, Scott, Heather, Chen, Tina, Winters, Mary, Petricoin, Emanuel F., Liotta, Lance A., ...
Protein microarrays offer a new means by which to conduct quantitative profiling of disease-associated proteins. The knowledge gained may provide novel strategies for early detection, diagnosis and...
Serum Proteomic Patterns for Detection of Prostate Cancer (2002)
Petricoin, Emanuel F., Ornstein, David K., Paweletz, Cloud P., Ardekani, Ali, Hackett, Paul S., Hitt, Ben A., ...
Pathologic states within the prostate may be reflected by changes in serum proteomic patterns. To test this hypothesis, we analyzed serum proteomic mass spectra with a bioinformatics tool to reveal...
Beyond the genome to tissue proteomics (1999)
Liotta, Lance A, Petricoin, Emanuel F
No abstract available.
Drosophila screening model for metastasis: Semaphorin 5c is required for l(2)gl cancer phenotype
Woodhouse, Elisa C., Fisher, Amy, Bandle, Russell W., Bryant-Greenwood, Bianca, Charboneau, Lula, Petricoin, Emanuel F., ...
Cancer metastasis is a complex process involving many genes and pathways. This complexity hinders the identification of molecules functionally required for this process. We have developed and used a...
Iyengar, Puneeth, Espina, Virginia, Williams, Terence W., Lin, Ying, Berry, David, Jelicks, Linda A., ...
The interactions of transformed cells with the surrounding stromal cells are of importance for tumor progression and metastasis. The relevance of adipocyte-derived factors to breast cancer cell...
Tong, Weida, Xie, Qian, Hong, Huixiao, Fang, Hong, Shi, Leming, Perkins, Roger, ...
Class prediction using “omics” data is playing an increasing role in toxicogenomics, diagnosis/prognosis, and risk assessment. These data are usually noisy and represented by relatively few...
Serum peptidome for cancer detection: spinning biologic trash into diagnostic gold
Liotta, Lance A., Petricoin, Emanuel F.
The low molecular weight region of the serum peptidome contains protein fragments derived from 2 sources: (a) high-abundance endogenous circulating proteins and (b) cell and tissue proteins. While...
Drosophila screening model for metastasis: Semaphorin 5c is required for l(2)gl cancer phenotype
Woodhouse, Elisa C., Fisher, Amy, Bandle, Russell W., Bryant-Greenwood, Bianca, Charboneau, Lula, Petricoin, Emanuel F., ...
Cancer metastasis is a complex process involving many genes and pathways. This complexity hinders the identification of molecules functionally required for this process. We have developed and used a...
Iyengar, Puneeth, Espina, Virginia, Williams, Terence W., Lin, Ying, Berry, David, Jelicks, Linda A., ...
The interactions of transformed cells with the surrounding stromal cells are of importance for tumor progression and metastasis. The relevance of adipocyte-derived factors to breast cancer cell...
Tong, Weida, Xie, Qian, Hong, Huixiao, Fang, Hong, Shi, Leming, Perkins, Roger, ...
Class prediction using “omics” data is playing an increasing role in toxicogenomics, diagnosis/prognosis, and risk assessment. These data are usually noisy and represented by relatively few...
Serum peptidome for cancer detection: spinning biologic trash into diagnostic gold
Liotta, Lance A., Petricoin, Emanuel F.
The low molecular weight region of the serum peptidome contains protein fragments derived from 2 sources: (a) high-abundance endogenous circulating proteins and (b) cell and tissue proteins. While...
Smith, Fraser M., Gallagher, William M., Fox, Edward, Stephens, Richard B., Rexhepaj, Elton, Petricoin, Emanuel F., ...
SELDI-TOF analysis was performed on 115 sequential serum samples taken from 20 patients with rectal cancer during the course of neoadjuvant radiochemotherapy. Biostatistical analysis of spectra...
Sakamoto, Norihisa, Tsuji, Kazuhide, Muul, Linda M., Lawler, Ann M., Petricoin, Emanuel F., Candotti, Fabio, ...
Recent studies have demonstrated that cell populations intended for therapeutic purposes that are cultured in heterologous animal products can acquire xenoantigens, potentially limiting their...
Core-Shell Hydrogel Particles Harvest, Concentrate and Preserve Labile Low Abundance Biomarkers
Longo, Caterina, Patanarut, Alexis, George, Tony, Bishop, Barney, Zhou, Weidong, Fredolini, Claudia, ...
Proteomics Discovery of Disease Biomarkers
Ahram, Mamoun, Petricoin, Emanuel F.
Recent technological developments in proteomics have shown promising initiatives in identifying novel biomarkers of various diseases. Such technologies are capable of investigating multiple samples...
Tahara, Hideaki, Sato, Marimo, Thurin, Magdalena, Wang, Ena, Butterfield, Lisa H, Disis, Mary L, ...
Supported by the Office of International Affairs, National Cancer Institute (NCI), the "US-Japan Workshop on Immunological Biomarkers in Oncology" was held in March 2009. The workshop was related to...
VanMeter, Amy J., Rodriguez, Adrianna S., Bowman, Elise D., Jen, Jin, Harris, Curtis C., Deng, Jianghong, ...
Little is known about lung carcinoma epidermal growth factor (EGF) kinase pathway signaling within the context of the tissue microenvironment. We quantitatively profiled the phosphorylation and...
A Portrait of Tissue Phosphoprotein Stability in the Clinical Tissue Procurement Process*
Espina, Virginia, Edmiston, Kirsten H., Heiby, Michael, Pierobon, Mariaelena, Sciro, Manuela, Merritt, Barbara, ...
Little is known about the preanalytical fluctuations of phosphoproteins during tissue procurement for molecular profiling. This information is crucial to establish guidelines for the reliable...
Havaleshko, Dmytro M, Smith, Steven Christopher, Cho, HyungJun, Cheon, Sooyoung, Owens, Charles R, Lee, Jae K, ...
Chemotherapy for metastatic bladder cancer is rarely curative. The recently developed small molecule, lapatinib, a dual epidermal growth factor receptor (EGFR)/human epidermal growth factor...