Bucca, Giselda, Laing, Emma, Mersinias, Vassilis, Allenby, Nicholas, Hurd, Douglas, Holdstock, Jolyon, ...
Abstract Background DNA microarrays are a key resource for global analysis of genome content, gene expression and the distribution of transcription factor binding sites. We describe the development...
Laing, Emma, Sidhu, Khushwant, Hubbard, Simon J
Abstract Background As a polycistronic transcriptional unit of one or more adjacent genes, operons play a key role in regulation and function in prokaryotic biology, and a better understanding of how...
in Escherichia coli and Streptomyces coelicolor (2008)
Bmc Genomics, Emma Laing, Khushwant Sidhu, Simon J Hubbard, Simon J Hubbard
Research article Predicted transcription factor binding sites as predictors of operons
Hesketh, Andy, Bucca, Giselda, Laing, Emma, Flett, Fiona, Hotchkiss, Graham, Smith, Colin P, ...
Abstract Background In Streptomyces coelicolor , bldA encodes the only tRNA for a rare leucine codon, UUA. This tRNA is unnecessary for growth, but is required for some aspects of secondary...
Analysis of gene expression in operons of Streptomyces coelicolor (2006)
Laing, Emma, Mersinias, Vassilis, Smith, Colin P, Hubbard, Simon J
Abstract Background Recent studies have shown that microarray-derived gene-expression data are useful for operon prediction. However, it is apparent that genes within an operon do not conform to the...
Analysis of gene expression in operons of Streptomyces coelicolor
Laing, Emma, Mersinias, Vassilis, Smith, Colin P, Hubbard, Simon J
Analysis of the relative transcript levels of intra-operonic genes in Streptomyces coelicolor suggests significant levels of internal regulation.
Bucca, Giselda, Laing, Emma, Mersinias, Vassilis, Allenby, Nicholas, Hurd, Douglas, Holdstock, Jolyon, ...
Development of high-density microarrays for global analysis of gene expression and transcription factor binding in Streptomyces coelicolor suggests a novel role for HspR in stress adaptation.