Chames, Patrick, Epinat, Jean-Charles, Guillier, Sophie, Patin, Amélie, Lacroix, Emmanuel, Pâques, Frédéric
Homing endonucleases, endonucleases capable of recognizing long DNA sequences, have been shown to be a tool of choice for precise and efficient genome engineering. Consequently, the possibility to...
A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells (2003)
Epinat, Jean-Charles, Arnould, Sylvain, Chames, Patrick, Rochaix, Pascal, Desfontaines, Dominique, Puzin, Clémence, ...
Homologous gene targeting is the ultimate tool for reverse genetics, but its use is often limited by low efficiency. In a number of recent studies, site‐ specific DNA double‐strand breaks...
Computational estimation of specific side chain interaction energies in {{alpha}} helices (2001)
Fisinger, Samo, Serrano, Luis, Lacroix, Emmanuel
We have used a structure energy-based computer program developed for protein design, Perla, to provide theoretical estimates of all specific side chain–side chain interaction energies occurring in...
Combinatorial approaches: A new tool to search for highly structured β-hairpin peptides
Pastor, Maria Teresa, Lacroix, Emmanuel, Serrano, Luis, Pérez-Payá, Enrique
Here we present a combinatorial approach to evolve a stable β-hairpin fold in a linear peptide. Starting with a de novo-designed linear peptide that shows a β-hairpin structure population of around...
De novo designed peptide-based amyloid fibrils
Goldie, Kenneth, Zurdo, Jesús, Lacroix, Emmanuel, Dobson, Christopher M., Hoenger, Andreas, ...
Identification of therapeutic strategies to prevent or cure diseases associated with amyloid fibril deposition in tissue (Alzheimer's disease, spongiform encephalopathies, etc.) requires a rational...
A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells
Epinat, Jean-Charles, Arnould, Sylvain, Chames, Patrick, Rochaix, Pascal, Desfontaines, Dominique, Puzin, Clémence, ...
Homologous gene targeting is the ultimate tool for reverse genetics, but its use is often limited by low efficiency. In a number of recent studies, site- specific DNA double-strand breaks (DSBs) have...
Chames, Patrick, Epinat, Jean-Charles, Guillier, Sophie, Patin, Amélie, Lacroix, Emmanuel, Pâques, Frédéric
Homing endonucleases, endonucleases capable of recognizing long DNA sequences, have been shown to be a tool of choice for precise and efficient genome engineering. Consequently, the possibility to...
Combinatorial approaches: A new tool to search for highly structured β-hairpin peptides
Pastor, Maria Teresa, Lacroix, Emmanuel, Serrano, Luis, Pérez-Payá, Enrique
Here we present a combinatorial approach to evolve a stable β-hairpin fold in a linear peptide. Starting with a de novo-designed linear peptide that shows a β-hairpin structure population of around...
De novo designed peptide-based amyloid fibrils
Goldie, Kenneth, Zurdo, Jesús, Lacroix, Emmanuel, Dobson, Christopher M., Hoenger, Andreas, ...
Identification of therapeutic strategies to prevent or cure diseases associated with amyloid fibril deposition in tissue (Alzheimer's disease, spongiform encephalopathies, etc.) requires a rational...
A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells
Epinat, Jean-Charles, Arnould, Sylvain, Chames, Patrick, Rochaix, Pascal, Desfontaines, Dominique, Puzin, Clémence, ...
Homologous gene targeting is the ultimate tool for reverse genetics, but its use is often limited by low efficiency. In a number of recent studies, site- specific DNA double-strand breaks (DSBs) have...
Chames, Patrick, Epinat, Jean-Charles, Guillier, Sophie, Patin, Amélie, Lacroix, Emmanuel, Pâques, Frédéric
Homing endonucleases, endonucleases capable of recognizing long DNA sequences, have been shown to be a tool of choice for precise and efficient genome engineering. Consequently, the possibility to...
Computational estimation of specific side chain interaction energies in α helices
Fisinger, Samo, Serrano, Luis, Lacroix, Emmanuel
We have used a structure energy-based computer program developed for protein design, Perla, to provide theoretical estimates of all specific side chain–side chain interaction energies occurring in...