Jingru ZHANG, Nan SONG, Xinshan JIA, Shanliang SUN, Xiaobo MA, Enhua WANG
Background and objective Although there are increasing reports on localization of tracheal stem cells, the mechanism of proliferation and differentiation of tracheal stem cells remains unclear....
Shuli LIU, Hongtao XU, Lianhe YANG, Qingchang LI, Qiang WEI, Enhua WANG
Background and objective Axin is an important negative regulator of Wnt signaling pathway. It can induce the phosphorylation and degradation of β-catenin. The reduced expression of axin or high...
Minghao WANG, Yang LIU, Shuli LIU, Enhua WANG
Background and objective To explore the correlation between p120-catenin (p120ctn) and small GTPases in human lung cancer, and their effect on the cell-cell adhesion, we examined the expression...
Shuli LIU, Nan LIU, Xiaoshi YANG, Hongtao XU, Enhua WANG
Background and objective Increasing reports showed that some tumor stem cells were selfrenewal and multi-lineage differentiated in tumors, similar to the normal stem cells in human body. The aim of...
Shuli LIU, Yang LIU, Nan LIU, Enhua WANG
Background and objective p120-catenin (p120ctn), a member of the Armadillo gene family, hasemerged as an important modulator of small GTPase activities. Therefore, it plays novel roles in tumor...
Meta Analysis of Association between Polymorphisms in Promoter Region of MMPs gene and (2009)
Shuli LIU, Yang LIU, Nan LIU, Enhua WANG
Background and objective p120-catenin (p120ctn), a member of the Armadillo gene family, has emerged as an important modulator of small GTPase activities. Therefore, it plays novel roles in tumor...
Ablation of p120-Catenin Altering the Activity of Small GTPase in Human Lung Cancer Cells (2009)
Shuli LIU, Yang LIU, Nan LIU, Enhua WANG
Background and objective p120-catenin (p120ctn), a member of the Armadillo gene family, has emerged as an important modulator of small GTPase activities. Therefore, it plays novel roles in tumor...
Changqing FANG, Yang LIU, Nan LIU, Yong ZHANG, Enhua WANG
Background and objective Different isoforms of p120-catenin (p120ctn), the members of catenin family, are variably expressed in different tissues and cells. These isoforms may confer different...
Heparanase Expression Correlates with Angiogenesis and Lymphangiogenesis in Human Lung Cancer (2009)
Qingfu ZHANG, Jian MING, Yang LI, Siyang ZHANG, Bo LI, Xueshan QIU, ...
Background and objective Heparanase has been thought to be a good molecular marker of tumor, and the heparanase expression level was correlated closely with tumor metastasis. In this study, we...
hsa-miR-125a-5p Enhances Invasion Ability in Non-Small Lung Carcinoma Cell Lines (2009)
Lili JIANG, Qingfu ZHANG, Jihong CHANG, Xueshan QIU, Enhua WANG
Background and objective MicroRNAs (miRNAs) are short non-coding RNAs that posttranscriptionally regulate gene expression by partially binding complementary to target sites in mRNAs. Although some...
Lili JIANG, Qingfu ZHANG, Hongji CHANG, Xueshan QIU, Enhua WANG
Background and objective MicroRNAs (miRNAs) are endogenous, non-coding small RNA in eukaryotes. They recognize their target sites by incomplete base pairing and posttranscriptionally regulate gene...
SOCS3 inhibiting migration of A549 cells correlates with PYK2 signaling in vitro (2008)
Zhang, Siyang, Guo, Dawei, Jiang, Lili, Zhang, Qingfu, Qiu, Xueshan, Wang, Enhua
Abstract Background Suppressor of cytokine signaling 3 (SOCS3) is considered to inhibit cytokine responses and play a negative role in migration of various cells. Proline-rich tyrosine kinase 2...
Lan LUAN, Yong ZHANG, Ning GUO, Enhua WANG
Background and objective Frat proteins are positive regulator of Wnt-signal transduction.By binding to GSK3,Frat prevents the phosphorylation and concomitant degradation of beta-catenin and allows...
Expression and significance of p120ctn isoforms in lung squamous cell carcinomas (2008)
Yuan MIAO, Yang LIU, Yan WANG, Enhua WANG
Background and Objective It has been proven that p120ctn plaied an important role in cell adhesion and correlates with tumorigenesis significantly, the aim of this work is to investigate the...
High Expression of TCF-4 Positively Correlated with Lung Cancer Progression (2008)
Lianhe YANG, Hongtao XU, Yan WANG, Yang LIU, Yue ZHAO, Shundong DAI, ...
Background and objective TCF-4 is an important downstream molecule of Wnt signaling pathway, but studies on the expression level and significance of TCF-4 in lung cancer were still limited. The aim...
Siyang ZHANG, Qingfu ZHANG, Yumei GU, Enhua WANG, Xueshan QIU
Background and objective It has been proven that suppressor of cytokine signaling 3 (SOCS3) contributes to inhibition of cell overgrowth, induction of apoptosis and stabilization. In the present...
Expression and clinical significance of RhoC and RhoGDIa in non-small cell lung cancer (2008)
Yuchen HAN, Yanni WU, Shuang GAO, Yuexin XU, Zhongyan GUAN, Xueshan QIU, ...
Background and objective RhoC is known to be overexpressed in cancer and to regulate motility of cancer cells. The activities of RhoC are negatively regulated by guanine nucleotide dissociation...
Dongming LIU, Yuexin XU, Zhongyan GUAN, Hongmei DUAN, Enhua WANG, Yuchen HAN
Background and objective It has been proven that RhoC is known to be overexpressed in tumor. The activities of RhoC are negatively regulated by guanine nucleotide dissociation inhibitor...
Effects of hypoxia on the expression of CCR7 and proliferation, invasiveness of A549 cells (2008)
Yang LI, Qingfu ZHANG, Yang WANG, Xueshan QIU, Enhua WANG
Background and objective It has been proven that hypoxia could promote tumor cells invasion and metastasis by different mechanisms, but the relationship between hypoxia and CCR7 have not been...
Yang LI, Qingfu ZHANG, Lili JIANG, Xueshan QIU, Enhua WANG
Background and objective CCR7 is closely related with the lymph node metastasis of non-small cell lung cancer. The objective of this work is to investigate the expressions of chemokine receptor CCR7,...