Eric D. Hsi

Apo2L/TRAIL and Bcl-2–related proteins regulate type I interferon–induced apoptosis in multiple myeloma

Chen, Quan, Gong, Bendi, Mahmoud-Ahmed, Ashraf S., Zhou, Aimin, Hsi, Eric D., Hussein, Mohamad, ...

It has been reported that interferons (IFNs) may have antitumor activity in multiple myeloma (MM). The mechanism for their effect on MM, however, remains elusive. This study shows that IFN-α and...

Characterization of the Interleukin-1β-Converting Enzyme/Ced-3-Family Protease, Caspase-3/CPP32, in Hodgkin’s Disease : Lack of Caspase-3 Expression in Nodular Lymphocyte Predominance Hodgkin’s Disease

Izban, Keith F., Wrone-Smith, Tamara, Hsi, Eric D., Schnitzer, Bertram, Quevedo, Maria Eugenia, Alkan, Serhan

Apoptosis (programmed cell death) serves an important role in the normal morphogenesis, immunoregulation, and homeostatic mechanisms in both normal and neoplastic cells. Caspase-3/CPP32, a member of...

Prognostic significance of Bcl-6 protein expression in DLBCL treated with CHOP or R-CHOP: a prospective correlative study

Winter, Jane N., Weller, Edie A., Horning, Sandra J., Krajewska, Maryla, Variakojis, Daina, Habermann, Thomas M., ...

Bcl-6 protein expression, a marker of germinal center origin, has been associated with a favorable prognosis in diffuse large B-cell lymphoma (DLBCL). To determine the prognostic significance of this...

T-Cell Protein Tyrosine Phosphatase, Distinctively Expressed in Activated-B-Cell-Like Diffuse Large B-Cell Lymphomas, Is the Nuclear Phosphatase of STAT6▿

Lu, Xiaoqing, Chen, Jun, Sasmono, R. Tedjo, Hsi, Eric D., Sarosiek, Kristopher A., Tiganis, Tony, ...

Diffuse large B-cell lymphomas (DLBCLs) consist of clinically distinct subtypes: germinal center B-cell (GCB)-like and activated-B-cell (ABC)-like tumors, characterized by long and short survival,...

Refractory anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-T), another myeloproliferative condition characterized by JAK2 V617F mutation

Szpurka, Hadrian, Tiu, Ramon, Murugesan, Gurunathan, Aboudola, Samer, Hsi, Eric D., Theil, Karl S., ...

JAK2 V617F mutation recently was identified as a pathogenic factor in typical chronic myeloproliferative diseases (CMPD). Some forms of myelodysplastic syndromes (MDS) show a significant overlap with...

Molecular strategies for detection and quantitation of clonal cytotoxic T-cell responses in aplastic anemia and myelodysplastic syndrome

Wlodarski, Marcin W., Gondek, Lukasz P., Nearman, Zachary P., Plasilova, Magdalena, Kalaycio, Matt, Hsi, Eric D., ...

Immune mechanisms are involved in the pathophysiology of aplastic anemia (AA) and myelodysplastic syndrome (MDS). Immune inhibition can result from cytotoxic T cell (CTL) attack against normal...

Expression of the human germinal center–associated lymphoma (HGAL) protein identifies a subset of classic Hodgkin lymphoma of germinal center derivation and improved survival

Natkunam, Yasodha, Hsi, Eric D., Aoun, Patricia, Zhao, Shuchun, Elson, Paul, Pohlman, Brad, ...

The human germinal-center–associated lymphoma (HGAL) gene and its cognate protein are expressed in a germinal center (GC)–specific manner. Its expression in classic Hodgkin lymphoma (cHL)...

Cytoplasmic localization of phosphorylated STAT5 in human acute myeloid leukemia is inversely correlated with Flt3-ITD

Bunting, Kevin D., Xie, Xiu Yan, Warshawsky, Ilka, Hsi, Eric D.

Quantitative In Situ Detection of Phosphoproteins in Fixed Tissues Using Quantum Dot Technology

Bodo, Juraj, Durkin, Lisa, Hsi, Eric D.

Detection and quantitation of phosphoproteins (PPs) in fixed tissues will become increasingly important as additional inhibitors of protein kinases enter clinical use and new disease entities are...

Differential diagnosis of cyclin D2+ mantle cell lymphoma based on fluorescence in situ hybridization and quantitative real-time-PCR

Quintanilla-Martinez, Leticia, Slotta-Huspenina, Julia, Koch, Ina, Klier, Margit, Hsi, Eric D., De Leval, Laurence, ...

The recognition of cyclin D1-negative mantle cell lymphoma is challenging. In this study the authors show that the quantification of cyclin D2 mRNA levels but not its immunohistochemical detection...