Eric Herlenius

Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor

Johansson, Björn, Halldner, Linda, Dunwiddie, Thomas V., Masino, Susan A., Poelchen, Wolfgang, Giménez-Llort, Lydia, ...

Caffeine is believed to act by blocking adenosine A1 and A2A receptors (A1R, A2AR), indicating that some A1 receptors are tonically activated. We generated mice with a targeted disruption of the...

Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant mice

Nsegbe, Elise, Wallén-Mackenzie, Åsa, Dauger, Stephane, Roux, Jean-Christophe, Shvarev, Yuri, Lagercrantz, Hugo, ...

Nurr1, a transcription factor belonging to the family of nuclear receptors, is expressed at high levels immediately after birth. Gene-targeted mice lacking Nurr1 fail to develop midbrain dopaminergic...

Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor

Johansson, Björn, Halldner, Linda, Dunwiddie, Thomas V., Masino, Susan A., Poelchen, Wolfgang, Giménez-Llort, Lydia, ...

Caffeine is believed to act by blocking adenosine A1 and A2A receptors (A1R, A2AR), indicating that some A1 receptors are tonically activated. We generated mice with a targeted disruption of the...

Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant mice

Nsegbe, Elise, Wallén-Mackenzie, Åsa, Dauger, Stephane, Roux, Jean-Christophe, Shvarev, Yuri, Lagercrantz, Hugo, ...

Nurr1, a transcription factor belonging to the family of nuclear receptors, is expressed at high levels immediately after birth. Gene-targeted mice lacking Nurr1 fail to develop midbrain dopaminergic...

The induced prostaglandin E2 pathway is a key regulator of the respiratory response to infection and hypoxia in neonates

Hofstetter, Annika O., Saha, Sipra, Siljehav, Veronica, Jakobsson, Per-Johan, Herlenius, Eric

Infection during the neonatal period commonly induces apnea episodes, and the proinflammatory cytokine IL-1β may serve as a critical mediator between these events. To determine the mechanism by...

Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block

Salomonsson, Stina, Sonesson, Sven-Erik, Ottosson, Lars, Muhallab, Saad, Olsson, Tomas, Sunnerhagen, Maria, ...

Congenital heart block develops in fetuses after placental transfer of Ro/SSA autoantibodies from rheumatic mothers. The condition is often fatal and the majority of live-born children require a...

Adenosinergic modulation of respiratory neurones in the neonatal rat brainstem in vitro

Herlenius, Eric, Lagercrantz, Hugo

The mechanism underlying adenosinergic modulation of respiration was examined in vitro by applying the whole-cell patch-clamp technique to different types of respiration-related neurones located in...