Expression of transmembrane carbonic anhydrases, CAIX and CAXII, in human development (2009)
Liao, Shu-Yuan, Lerman, Michael I, Stanbridge, Eric J
Abstract Background Transmembrane CAIX and CAXII are members of the alpha carbonic anhydrase (CA) family. They play a crucial role in differentiation, proliferation, and pH regulation. Expression of...
p53-Dependent Chk1 Phosphorylation is Required for Maintenance of Prolonged G2 Arrest (2007)
Xiao Qi Wang, Eric J. Stanbridge, Xiaoyan Lao, Qi Cai, Sheung Tat Fan, J. Leslie Redpath
Expression of hypoxia-inducible carbonic anhydrases in brain tumors (2005)
Proescholdt, Martin A., Mayer, Christina, Kubitza, Marion, Schubert, Thomas, Liao, Shu-Yuan, Stanbridge, Eric J., ...
Malignant brain tumors exhibit distinct metabolic characteristics. Despite high levels of lactate, the intracellular pH of brain tumors is more alkaline than normal brain. Additionally, with...
J. Leslie Redpath, Ulla Bengtsson, John DeSimone, Xiaoyan Lao, Xiaoqi Wang, Eric J. Stanbridge
Redpath, J. L., Bengtsson, U., DeSimone, J., Lao, X., Wang, X. and Stanbridge, E. J. Sticky Anaphase Aberrations after G2-Phase Arrest of Gamma-Irradiated Human Skin Fibroblasts: TP53 Independence of...
John N. DeSimone, Ulla Bengtsson, XiaoQi Wang, Xiao Yan Lao, J. Leslie Redpath, Eric J. Stanbridge
DeSimone, J. N., Bengtsson, U., Wang, X. Q., Lao, X. Y., Redpath, J. L, and Stanbridge, E. J. Complexity of the Mechanisms of Initiation and Maintenance of DNA Damage-Induced G2-Phase Arrest and...
Cao, Jia-ning, Gao, Tian-wen, Stanbridge, Eric J., Irie, Reiko
Background: Antibodies isolated from cancer patients have been used to identify genes encoding tumor-associated antigen epitopes relevant to immune responses in cancer patients. In this report, we...
John N. DeSimone, Hana Dolezalova, J. Leslie Redpath, Eric J. Stanbridge
DeSimone, J.N., Dolezalova, H., Redpath, J.L. and Stanbridge, E.J. Prolonged Cell Cycle Arrest in Irradiated Human Diploid Skin Fibroblasts: The Role of Nutrient Deprivation. Ionizing radiation has...
Reduction of Caveolin-1 Expression in Tumorigenic Human Cell Hybrids (1998)
Suzuki, Toshikazu, Suzuki, Yasuyuki, Hanada, Kentaro, Hashimoto, Akihiro, Redpath, J. Leslie, Stanbridge, Eric J., ...
Studies on human cell hybrids of a cervical carcinoma cell line, HeLa, and normal fibroblasts have indicated that the tumorigenicity of these cells is under the control of a putative tumor suppressor...
Extreme evolutionary conservation of QM, a novel c-Jun associated transcription factor (1994)
Farmer, Andrew A., Loftus, Thomas M., Mills, Alea A., Sato, Kevin Y., Neill, John D., Tron, Thierry, ...
QM Is a 214 amino acid polypeptide, encoded by a gene (DXS648) In Xq28, that contains a high percentage of charged amino acids and has been found to bind c-Jun and DNA. Searches of the GenBank...
Functional evidence for a breast cancer growth suppressor gene on chromosome 17 (1993)
Casey, Graham, Plummer, Sarah, Hoeltge, Gerald, Scanlon, David, Fasching, Clare, Stanbridge, Eric J.
Rearrangements or deletions of chromosome 17 are the most frequently observed genetic changes identified in breast tumors. Molecular analyses suggest that in addition to the p53 gene on 17p13.1 there...
Meese, Eckart U., Witkowski, Colette M., Zoghbi, Huda Y., Stanbridge, Eric J., Meltzer, Paul S., Trent, Jeffrey M.
A somatic cell hybrid mapping panel that defines seven regions of the long arm and one region of the short arm of human chromosome 6 has been developed. Utilizing this panel, 17 NotI boundary clones...
Grunicke, Hans, Stoeck, Michael, Elsner, J., Seemann, G., Pfeiffer, C., Wegmann, B., ...
Peer Reviewed
Zabarovsky, Eugene R., Boldog, Ferenc, Thompson, Teryl, Scanlon, David, Winberg, Gösta, Marcsek, Zoltán, ...
Two new diphasmid vectors (lambda SK17 and SK22) and a novel procedure to construct linking libraries are described. A partial filling-in reaction provides counter-selection against false linking...
Interactions between mycoplasmas and human cells in culture. (1971)
Thesis (Ph. D.)--Dept. of Medical Microbiology, Stanford University, 1972.
Cheng, Yue, Poulos, Nicholas E., Lung, Maria L., Hampton, Garret, Ou, Baoxiang, Lerman, Michael I., ...
Nasopharyngeal carcinoma is a malignancy that is prevalent among populations from Southeast Asia. Epidemiological studies indicate that genetic predisposition, Epstein–Barr virus, and environmental...
Ivanov, Sergey V., Kuzmin, Igor, Wei, Ming-Hui, Pack, Svetlana, Geil, Laura, Johnson, Bruce E., ...
To discover genes involved in von Hippel-Lindau (VHL)-mediated carcinogenesis, we used renal cell carcinoma cell lines stably transfected with wild-type VHL-expressing transgenes. Large-scale RNA...
Bleuel, Kerstin, Popp, Susanne, Fusenig, Norbert E., Stanbridge, Eric J., Boukamp, Petra
The development of skin carcinomas presently is believed to be correlated with mutations in the p53 tumor suppressor and ras gene as well as with the loss of chromosome 9. We now demonstrate that, in...
Dreijerink, Koen, Braga, Eleonora, Kuzmin, Igor, Geil, Laura, Duh, Fuh-Mei, Angeloni, Debora, ...
Clear cell-type renal cell carcinomas (clear RCC) are characterized almost universally by loss of heterozygosity on chromosome 3p, which usually involves any combination of three regions: 3p25-p26...
Aurelio, Oscar N., Kong, Xiao-Tang, Gupta, Swati, Stanbridge, Eric J.
A bidirectional expression vector that allowed equal transcription of cloned wild-type and mutant p53 cDNAs from the same vector was developed. The vector was transfected into CaLu 6 lung carcinoma...
Role of Phosphoinositide 3-Kinase in the Aggressive Tumor Growth of HT1080 Human Fibrosarcoma Cells
Gupta, Swati, Stuffrein, Selma, Plattner, Rina, Tencati, Michael, Gray, Christa, Whang, Young E., ...
We have developed a model system of human fibrosarcoma cell lines that do or do not possess and express an oncogenic mutant allele of N-ras. HT1080 cells contain an endogenous mutant allele of N-ras,...
Gupta, Swati, Plattner, Rina, Der, Channing J., Stanbridge, Eric J.
Activation of multiple signaling pathways is required to trigger the full spectrum of in vitro and in vivo phenotypic traits associated with neoplastic transformation by oncogenic Ras. To determine...
Doersen, Claus-Jens, Stanbridge, Eric J.
The characterization of two new erythromycin-resistant mutants of HeLa cells is described. The strains ERY2305 and ERY2309 both exhibited resistance to erythromycin in growth assays and cell-free...
Kaluzová, Milota, Kaluz, Stefan, Lerman, Michael I., Stanbridge, Eric J.
We investigated the relationship between the tumor suppressor p53 and the hypoxia-inducible factor-1 (HIF-1)-dependent expression of the hypoxia marker, carbonic anhydrase IX (CAIX). MCF-7 (wt p53)...
Kaluz, Stefan, Kaluzová, Milota, Stanbridge, Eric J.
The ubiquitin-proteasome pathway (UPP) is involved in regulation of multiple cellular processes. Hypoxia-inducible factor 1α (HIF-1α) is a prototypic target of the UPP and, as such, is stabilized...
Cheng, Yue, Poulos, Nicholas E., Lung, Maria L., Hampton, Garret, Ou, Baoxiang, Lerman, Michael I., ...
Nasopharyngeal carcinoma is a malignancy that is prevalent among populations from Southeast Asia. Epidemiological studies indicate that genetic predisposition, Epstein–Barr virus, and environmental...
Ivanov, Sergey V., Kuzmin, Igor, Wei, Ming-Hui, Pack, Svetlana, Geil, Laura, Johnson, Bruce E., ...
To discover genes involved in von Hippel-Lindau (VHL)-mediated carcinogenesis, we used renal cell carcinoma cell lines stably transfected with wild-type VHL-expressing transgenes. Large-scale RNA...
Bleuel, Kerstin, Popp, Susanne, Fusenig, Norbert E., Stanbridge, Eric J., Boukamp, Petra
The development of skin carcinomas presently is believed to be correlated with mutations in the p53 tumor suppressor and ras gene as well as with the loss of chromosome 9. We now demonstrate that, in...
Dreijerink, Koen, Braga, Eleonora, Kuzmin, Igor, Geil, Laura, Duh, Fuh-Mei, Angeloni, Debora, ...
Clear cell-type renal cell carcinomas (clear RCC) are characterized almost universally by loss of heterozygosity on chromosome 3p, which usually involves any combination of three regions: 3p25-p26...
Aurelio, Oscar N., Kong, Xiao-Tang, Gupta, Swati, Stanbridge, Eric J.
A bidirectional expression vector that allowed equal transcription of cloned wild-type and mutant p53 cDNAs from the same vector was developed. The vector was transfected into CaLu 6 lung carcinoma...
Role of Phosphoinositide 3-Kinase in the Aggressive Tumor Growth of HT1080 Human Fibrosarcoma Cells
Gupta, Swati, Stuffrein, Selma, Plattner, Rina, Tencati, Michael, Gray, Christa, Whang, Young E., ...
We have developed a model system of human fibrosarcoma cell lines that do or do not possess and express an oncogenic mutant allele of N-ras. HT1080 cells contain an endogenous mutant allele of N-ras,...
Gupta, Swati, Plattner, Rina, Der, Channing J., Stanbridge, Eric J.
Activation of multiple signaling pathways is required to trigger the full spectrum of in vitro and in vivo phenotypic traits associated with neoplastic transformation by oncogenic Ras. To determine...
Doersen, Claus-Jens, Stanbridge, Eric J.
The characterization of two new erythromycin-resistant mutants of HeLa cells is described. The strains ERY2305 and ERY2309 both exhibited resistance to erythromycin in growth assays and cell-free...
Kaluzová, Milota, Kaluz, Stefan, Lerman, Michael I., Stanbridge, Eric J.
We investigated the relationship between the tumor suppressor p53 and the hypoxia-inducible factor-1 (HIF-1)-dependent expression of the hypoxia marker, carbonic anhydrase IX (CAIX). MCF-7 (wt p53)...
McDaniel, Lisa D., Tomkins, Darrell J., Stanbridge, Eric J., Somerville, Martin J., Friedberg, Errol C., Schultz, Roger A.
Roberts syndrome (RS) is a developmental disorder characterized by tetraphocomelia and a broad spectrum of additional clinical features. Most patients with RS exhibit characteristic cytogenetic...
Kaluz, Stefan, Kaluzová, Milota, Stanbridge, Eric J.
The ubiquitin-proteasome pathway (UPP) is involved in regulation of multiple cellular processes. Hypoxia-inducible factor 1α (HIF-1α) is a prototypic target of the UPP and, as such, is stabilized...
Expression of hypoxia-inducible carbonic anhydrases in brain tumors
Proescholdt, Martin A., Mayer, Christina, Kubitza, Marion, Schubert, Thomas, Liao, Shu-Yuan, Stanbridge, Eric J., ...
Malignant brain tumors exhibit distinct metabolic characteristics. Despite high levels of lactate, the intracellular pH of brain tumors is more alkaline than normal brain. Additionally, with...
Expression of Hypoxia-Inducible Cell-Surface Transmembrane Carbonic Anhydrases in Human Cancer
Ivanov, Sergey, Liao, Shu-Yuan, Ivanova, Alla, Danilkovitch-Miagkova, Alla, Tarasova, Nadezhda, Weirich, Gregor, ...
An acidic extracellular pH is a fundamental property of the malignant phenotype. In von Hippel-Lindau (VHL)-defective tumors the cell surface transmembrane carbonic anhydrase (CA) CA9 and CA12 genes...