Genome-wide association analysis by lasso penalized logistic regression (2009)
Wu, Tong Tong, Chen, Yi Fang, Hastie, Trevor, Sobel, Eric, Lange, Kenneth
Motivation: In ordinary regression, imposition of a lasso penalty makes continuous model selection straightforward. Lasso penalized regression is particularly advantageous when the number of...
Fine mapping of a multiple sclerosis locus to 2.5 Mb on chromosome 17q22-q24 (2002)
Saarela, Janna, Schoenberg Fejzo, Marlena, Chen, Daniel, Finnilä, Saara, Parkkonen, Maikki, Kuokkanen, Satu, ...
Genome-wide linkage analyses performed in a Finnish study sample have identified four potential predisposing loci for multiple sclerosis (MS). Here we made an effort to restrict the wide linkage...
Chromosome 1 loci in Finnish schizophrenia families (2001)
Ekelund, Jesper, Hovatta, Iiris, Parker, Alex, Paunio, Tiina, Varilo, Teppo, Martin, Rory, ...
We have earlier reported evidence for linkage to two regions on chromosome 1q32–q42 in schizophrenia families collected for two separate studies in Finland. Here we report the results of a fine...
A multiple sequence alignment program (1986)
Sobel, Eric, Martinez, Hugo M.
A program1 is described for simultaneously aligning two or more molecular sequences which is based on first finding common segments above a specified length and then piecing these together to...
Detection and Integration of Genotyping Errors in Statistical Genetics
Sobel, Eric, Papp, Jeanette C., Lange, Kenneth
Detection of genotyping errors and integration of such errors in statistical analysis are relatively neglected topics, given their importance in gene mapping. A few inopportunely placed errors, if...
A Susceptibility Locus for Migraine with Aura, on Chromosome 4q24
Wessman, Maija, Kallela, Mikko, Kaunisto, Mari A., Marttila, Pia, Sobel, Eric, Hartiala, Jaana, ...
Migraine is a complex neurovascular disorder with substantial evidence supporting a genetic contribution. Prior attempts to localize susceptibility loci for common forms of migraine have not produced...
Lange, Ethan, Borresen, Anna-Lise, Chen, Xiaoguang, Chessa, Luciana, Chiplunkar, Sujata, Concannon, Patrick, ...
We describe a 20-point linkage analysis map of chromosome 11q22-23 that is based on genotyping 249 families (59 CEPH and 190 A-T). Monte Carlo linkage analyses of 176 ataxia-telangiectasia (A-T)...
Nacionales, Dina C., Kelly, Kindra M., Lee, Pui Y., Zhuang, Haoyang, Li, Yi, Weinstein, Jason S., ...
Lymphoid neogenesis is associated with antibody-mediated autoimmune diseases such as Sjogren’s syndrome and rheumatoid arthritis. Although systemic lupus erythematosus is the prototypical...