Paul, Sandip, Bag, Sumit K, Das, Sabyasachi, Harvill, Eric T, Dutta, Chitra
Abstract Background Halophilic prokaryotes are adapted to thrive in extreme conditions of salinity. Identification and analysis of distinct macromolecular characteristics of halophiles provide...
Modeling Systems-Level Regulation of Host Immune Responses (2007)
Juilee Thakar, Mylisa Pilione, Girish Kirimanjeswara, Eric T. Harvill, Réka Albert
Many pathogens are able to manipulate the signaling pathways responsible for the generation of host immune responses. Here we examine and model a respiratory infection system in which disruption of...
Modeling Systems-Level Regulation of Host Immune Responses (2007)
Juilee Thakar, Mylisa Pilione, Girish Kirimanjeswara, Eric T Harvill, Reka Albert
Many pathogens are able to manipulate the signaling pathways responsible for the generation of host immune responses. Here we examine and model a respiratory infection system in which disruption of...
Harvill, Eric T., Cotter, Peggy A., Yuk, Ming Huam, Miller, Jeff F.
We have examined the role of adenylate cyclase-hemolysin (CyaA) by constructing an in-frame deletion in the Bordetella bronchiseptica cyaA structural gene and comparing wild-type and cyaA deletion...
Harvill, Eric T., Cotter, Peggy A., Miller, Jeff F.
We describe here a side-by-side comparison of murine respiratory infection by Bordetella pertussis and Bordetella bronchiseptica strains whose genomes are currently being sequenced (Tohama I and...
Multiple Roles for Bordetella Lipopolysaccharide Molecules during Respiratory Tract Infection
Harvill, Eric T., Preston, Andrew, Cotter, Peggy A., Allen, Andrew G., Maskell, Duncan J., Miller, Jeff F.
Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica are closely related subspecies that cause respiratory tract infections in humans and other mammals and express many...
Heininger, Ulrich, Cotter, Peggy A., Fescemyer, Howard W., Martinez De Tejada, Guillermo, Yuk, Ming H., Miller, Jeff F., ...
The genomes of three closely related bordetellae are currently being sequenced, thus providing an opportunity for comparative genomic approaches driven by an understanding of the comparative biology...
Role of Bordetella O Antigen in Respiratory Tract Infection
Burns, Valorie C., Pishko, Elizabeth J., Preston, Andrew, Maskell, Duncan J., Harvill, Eric T.
Lipopolysaccharide (LPS), as the major surface molecule of gram-negative bacteria, interacts with the host in complex ways, both inducing and protecting against aspects of inflammatory and adaptive...
Role of Antibodies in Immunity to Bordetella Infections
Kirimanjeswara, Girish S., Mann, Paul B., Harvill, Eric T.
The persistence of Bordetella pertussis and B. parapertussis within vaccinated populations and the reemergence of associated disease highlight the need to better understand protective immunity. The...
Bordetella pertussis Acquires Resistance to Complement-Mediated Killing In Vivo
Pishko, Elizabeth J., Betting, David J., Hutter, Christina S., Harvill, Eric T.
In order to initially colonize a host, bacteria must avoid various components of the innate immune system, one of which is complement. The genus Bordetella includes three closely related species that...
Liu, Minghsun, Gingery, Mari, Doulatov, Sergei R., Liu, Yichin, Hodes, Asher, Baker, Stephen, ...
Liu et al. recently described a group of related temperate bacteriophages that infect Bordetella subspecies and undergo a unique template-dependent, reverse transcriptase-mediated tropism switching...
Pilione, Mylisa R., Pishko, Elizabeth J., Preston, Andrew, Maskell, Duncan J., Harvill, Eric T.
To efficiently colonize and persist in the lower respiratory tract, bacteria must survive multiple host immune mechanisms. Bordetella bronchiseptica is a gram-negative respiratory pathogen that...
Strain-Dependent Role of BrkA during Bordetella pertussis Infection of the Murine Respiratory Tract
Elder, Kelly D., Harvill, Eric T.
Bordetella pertussis, the causative agent of whooping cough, expresses many virulence factors believed to be involved in infection and disease progression. While these factors as a group are required...
Mann, Paul B., Elder, Kelly D., Kennett, Mary J., Harvill, Eric T.
Toll-like receptor 4 (TLR4) mediates the response to lipopolysaccharide, and its activation induces the expression of a large number of inflammatory genes, many of which are also induced by other...
Wolfe, Daniel N., Kirimanjeswara, Girish S., Harvill, Eric T.
Bordetella parapertussis and Bordetella pertussis are closely related species that cause whooping cough, an acute, immunizing disease. Their coexistence in the same host populations at the same time...
Hughes, Molly A., Green, Candace S., Lowchyj, Lisa, Lee, Gloria M., Grippe, Vanessa K., Smith, Michael F., ...
Bacillus anthracis is a spore-forming, gram-positive organism that is the causative agent of the disease anthrax. Recognition of Bacillus anthracis by the host innate immune system likely plays a key...
Kirimanjeswara, Girish S., Agosto, Luis M., Kennett, Mary J., Bjornstad, Ottar N., Harvill, Eric T.
Whooping cough is considered a childhood disease, although there is growing evidence that children are infected by adult carriers. Additionally, increasing numbers of vaccinated adults are being...
Comparative Toll-Like Receptor 4-Mediated Innate Host Defense to Bordetella Infection
Mann, Paul B., Wolfe, Daniel, Latz, Eicke, Golenbock, Douglas, Preston, Andrew, Harvill, Eric T.
Bordetella pertussis, B. parapertussis, and B. bronchiseptica are closely related species associated with respiratory disease in humans and other mammals. While B. bronchiseptica has a wide host...
Complement Depletion Renders C57BL/6 Mice Sensitive to the Bacillus anthracis Sterne Strain
Harvill, Eric T., Lee, Gloria, Grippe, Vanessa K., Merkel, Tod J.
Concerns regarding safety and control of virulent Bacillus anthracis have created substantial hurdles to the study of anthrax. The Sterne strain is considered relatively safe to study, but this...
Pilione, Mylisa R., Harvill, Eric T.
Several species of pathogenic microorganisms have developed strategies to survive and persist in vital organs which are normally maintained as sterile by the generation of strong immune responses....
Harvill, Eric T., Cotter, Peggy A., Yuk, Ming Huam, Miller, Jeff F.
We have examined the role of adenylate cyclase-hemolysin (CyaA) by constructing an in-frame deletion in the Bordetella bronchiseptica cyaA structural gene and comparing wild-type and cyaA deletion...
Harvill, Eric T., Cotter, Peggy A., Miller, Jeff F.
We describe here a side-by-side comparison of murine respiratory infection by Bordetella pertussis and Bordetella bronchiseptica strains whose genomes are currently being sequenced (Tohama I and...
Multiple Roles for Bordetella Lipopolysaccharide Molecules during Respiratory Tract Infection
Harvill, Eric T., Preston, Andrew, Cotter, Peggy A., Allen, Andrew G., Maskell, Duncan J., Miller, Jeff F.
Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica are closely related subspecies that cause respiratory tract infections in humans and other mammals and express many...
Heininger, Ulrich, Cotter, Peggy A., Fescemyer, Howard W., Martinez De Tejada, Guillermo, Yuk, Ming H., Miller, Jeff F., ...
The genomes of three closely related bordetellae are currently being sequenced, thus providing an opportunity for comparative genomic approaches driven by an understanding of the comparative biology...
Role of Bordetella O Antigen in Respiratory Tract Infection
Burns, Valorie C., Pishko, Elizabeth J., Preston, Andrew, Maskell, Duncan J., Harvill, Eric T.
Lipopolysaccharide (LPS), as the major surface molecule of gram-negative bacteria, interacts with the host in complex ways, both inducing and protecting against aspects of inflammatory and adaptive...
Role of Antibodies in Immunity to Bordetella Infections
Kirimanjeswara, Girish S., Mann, Paul B., Harvill, Eric T.
The persistence of Bordetella pertussis and B. parapertussis within vaccinated populations and the reemergence of associated disease highlight the need to better understand protective immunity. The...
Bordetella pertussis Acquires Resistance to Complement-Mediated Killing In Vivo
Pishko, Elizabeth J., Betting, David J., Hutter, Christina S., Harvill, Eric T.
In order to initially colonize a host, bacteria must avoid various components of the innate immune system, one of which is complement. The genus Bordetella includes three closely related species that...
Liu, Minghsun, Gingery, Mari, Doulatov, Sergei R., Liu, Yichin, Hodes, Asher, Baker, Stephen, ...
Liu et al. recently described a group of related temperate bacteriophages that infect Bordetella subspecies and undergo a unique template-dependent, reverse transcriptase-mediated tropism switching...
Pilione, Mylisa R., Pishko, Elizabeth J., Preston, Andrew, Maskell, Duncan J., Harvill, Eric T.
To efficiently colonize and persist in the lower respiratory tract, bacteria must survive multiple host immune mechanisms. Bordetella bronchiseptica is a gram-negative respiratory pathogen that...
Strain-Dependent Role of BrkA during Bordetella pertussis Infection of the Murine Respiratory Tract
Elder, Kelly D., Harvill, Eric T.
Bordetella pertussis, the causative agent of whooping cough, expresses many virulence factors believed to be involved in infection and disease progression. While these factors as a group are required...
Mann, Paul B., Elder, Kelly D., Kennett, Mary J., Harvill, Eric T.
Toll-like receptor 4 (TLR4) mediates the response to lipopolysaccharide, and its activation induces the expression of a large number of inflammatory genes, many of which are also induced by other...
Complement Depletion Renders C57BL/6 Mice Sensitive to the Bacillus anthracis Sterne Strain
Harvill, Eric T., Lee, Gloria, Grippe, Vanessa K., Merkel, Tod J.
Concerns regarding safety and control of virulent Bacillus anthracis have created substantial hurdles to the study of anthrax. The Sterne strain is considered relatively safe to study, but this...
Wolfe, Daniel N., Kirimanjeswara, Girish S., Harvill, Eric T.
Bordetella parapertussis and Bordetella pertussis are closely related species that cause whooping cough, an acute, immunizing disease. Their coexistence in the same host populations at the same time...
Hughes, Molly A., Green, Candace S., Lowchyj, Lisa, Lee, Gloria M., Grippe, Vanessa K., Smith, Michael F., ...
Bacillus anthracis is a spore-forming, gram-positive organism that is the causative agent of the disease anthrax. Recognition of Bacillus anthracis by the host innate immune system likely plays a key...
Kirimanjeswara, Girish S., Agosto, Luis M., Kennett, Mary J., Bjornstad, Ottar N., Harvill, Eric T.
Whooping cough is considered a childhood disease, although there is growing evidence that children are infected by adult carriers. Additionally, increasing numbers of vaccinated adults are being...
Comparative Toll-Like Receptor 4-Mediated Innate Host Defense to Bordetella Infection
Mann, Paul B., Wolfe, Daniel, Latz, Eicke, Golenbock, Douglas, Preston, Andrew, Harvill, Eric T.
Bordetella pertussis, B. parapertussis, and B. bronchiseptica are closely related species associated with respiratory disease in humans and other mammals. While B. bronchiseptica has a wide host...
Pilione, Mylisa R., Harvill, Eric T.
Several species of pathogenic microorganisms have developed strategies to survive and persist in vital organs which are normally maintained as sterile by the generation of strong immune responses....
Modeling Systems-Level Regulation of Host Immune Responses
Thakar, Juilee, Pilione, Mylisa, Kirimanjeswara, Girish, Harvill, Eric T, Albert, Réka
Many pathogens are able to manipulate the signaling pathways responsible for the generation of host immune responses. Here we examine and model a respiratory infection system in which disruption of...
Comparative Role of Immunoglobulin A in Protective Immunity against the Bordetellae▿
Wolfe, Daniel N., Kirimanjeswara, Girish S., Goebel, Elizabeth M., Harvill, Eric T.
The genus Bordetella includes a group of closely related mammalian pathogens that cause a variety of respiratory diseases in a long list of animals (B. bronchiseptica) and whooping cough in humans...
The O Antigen Enables Bordetella parapertussis To Avoid Bordetella pertussis-Induced Immunity▿
Wolfe, Daniel N., Goebel, Elizabeth M., Bjornstad, Ottar N., Restif, Olivier, Harvill, Eric T.
Bordetella pertussis and Bordetella parapertussis are closely related endemic human pathogens which cause whooping cough, a disease that is reemerging in human populations. Despite how closely...
O Antigen Protects Bordetella parapertussis from Complement▿
Goebel, Elizabeth M., Wolfe, Daniel N., Elder, Kelly, Stibitz, Scott, Harvill, Eric T.
Bordetella pertussis, a causative agent of whooping cough, expresses BrkA, which confers serum resistance, but the closely related human pathogen that also causes whooping cough, Bordetella...