Evolution of pharmacologic specificity in the pregnane X receptor (2008)
Ekins, Sean, Reschly, Erica J, Hagey, Lee R, Krasowski, Matthew D
Abstract Background The pregnane X receptor (PXR) shows the highest degree of cross-species sequence diversity of any of the vertebrate nuclear hormone receptors. In this study, we determined the...
Functional evolution of the vitamin D and pregnane X receptors (2007)
Reschly, Erica J, Bainy, Afonso, Mattos, Jaco, Hagey, Lee R, Bahary, Nathan, Mada, Sripal R, ...
Abstract Background The vitamin D receptor (VDR) and pregnane X receptor (PXR) are nuclear hormone receptors of the NR1I subfamily that show contrasting patterns of cross-species variation. VDR and...
Reschly, Erica J., Spaulding, Christina, Vilimas, Tomas, Graham, W. Vallen, Brumbaugh, Rachel L., Aifantis, Iannis, ...
Loss of E2A transcription factor activity or activation of the intracellular form of Notch1 (ICN) leads to the development of leukemia or lymphoma in humans or mice, respectively. Current models...
Functional evolution of the vitamin D and pregnane X receptors
Reschly, Erica J, Bainy, Afonso Celso Dias, Mattos, Jaco Joaquim, Hagey, Lee R, Bahary, Nathan, Mada, Sripal R, ...
Evolution of pharmacologic specificity in the pregnane X receptor
Ekins, Sean, Reschly, Erica J, Hagey, Lee R, Krasowski, Matthew D
Evolution of the bile salt nuclear receptor FXR in vertebrates*s⃞
Reschly, Erica J., Ai, Ni, Ekins, Sean, Welsh, William J., Hagey, Lee R., Hofmann, Alan F., ...
Bile salts, the major end metabolites of cholesterol, vary significantly in structure across vertebrate species, suggesting that nuclear receptors binding these molecules may show adaptive...