BakgrundSystemet för containertransporter karaktäriseras utav stora omlastningshamnar som fungerar somhubbar för containertrafik från omkringliggande områden. Mindre fartyg och...
BakgrundSystemet för containertransporter karaktäriseras utav stora omlastningshamnar som fungerar somhubbar för containertrafik från omkringliggande områden. Mindre fartyg och...
Why Treatment Fails in Type 2 Diabetes (2008)
Anders Rosengren, Xingjun Jing, Lena Eliasson, Erik Renström
Speidel, Dina, Salehi, Albert, Obermueller, Stefanie, Lundquist, Ingmar, Brose, Nils, Renström, Erik, ...
Redox control of exocytosis: regulatory role of NADPH, thioredoxin, and glutaredoxin (2005)
Dejonghe, Sandra, In 't Veld, Peter, Renström, Erik, ...
Cellular redox state is an important metabolic variable, influencing many aspects of cell function like growth, apoptosis, and reductive biosynthesis. In this report, we identify NADPH as a candidate...
Björkqvist, Maria, Fex, Malin, Renström, Erik, Wierup, Nils, Petersén, Asa, Gil, Joana, ...
Abstract is not available
CaV2.3 calcium channels control second-phase insulin release. (2005)
Jing, Xingjun, Li, Dai-Qing, Olofsson, Charlotta S, Salehi, Albert, Surve, Vikas V, Caballero, José, ...
Abstract is not available
Björkqvist, Maria, Fex, Malin, Renström, Erik, Wierup, Nils, Petersén, Åsa, Gil, Joana, ...
Diabetes frequently develops in Huntington's disease (HD) patients and in transgenic mouse models of HD such as the R6/2 mouse. The underlying mechanisms have not been clarified. Elucidating the...
Björkqvist, Maria, Fex, Malin, Renström, Erik, Wierup, Nils, Petersén, Åsa, Gil, Joana, ...
Diabetes frequently develops in Huntington's disease (HD) patients and in transgenic mouse models of HD, such as the R6/2 mouse. The underlying mechanisms have not been clarified. Elucidating the...
Yang, Shumin, Fransson, Ulrika, Fagerhus, Lillian, Holst, Lena Stenson, Hohmeier, Hans E., Renström, Erik, ...
Abstract is not available
Ivarsson, Rosita, Obermüller, Stefanie, Rutter, Guy A, Galvanovskis, Juris, Renström, Erik
Glucose-evoked insulin secretion exhibits a biphasic time course and is associated with accelerated intracellular granule movement. We combined live confocal imaging of EGFP-labelled insulin granules...
SUR1 Regulates PKA-independent cAMP-induced Granule Priming in Mouse Pancreatic B-cells. (2003)
Eliasson, Lena, Ma, Xiaosong, Renström, Erik, Barg, Sebastian, Berggren, Per-Olof, Galvanovskis, Juris, ...
Abstract is not available
Schulla, Verena, Renström, Erik, Feil, Robert, Feil, Susanne, Franklin, Isobel, Gjinovci, Asllan, ...
Abstract is not available
Barg, Sebastian, Eliasson, Lena, Renström, Erik, Rorsman, Patrik
Capacitance measurements were applied to mouse pancreatic beta-cells to elucidate the cellular mechanisms underlying biphasic insulin secretion. We report here that only 10,000 granules are...
Renström, Erik, Barg, Sebastian, Thévenod, Frank, Rorsman, Patrik
Several reports indicate that hypoglycemic sulfonylureas augment Ca(2+)-dependent insulin secretion via mechanisms other than inhibition of the ATP-sensitive K(+) channel. The effect involves a 65-kd...
Barg, Sebastian, Olofsson, Charlotta S, Schriever-Abeln, Jenny, Wendt, Anna, Gebre-Medhin, Samuel, Renström, Erik, ...
Peptidergic neurotransmission is slow compared to that mediated by classical neurotransmitters. We have studied exocytotic membrane fusion and cargo release by simultaneous capacitance measurements...
Renström, Erik, Ivarsson, Rosita, Shears, Stephen B
ClC Cl(-) channels in endosomes, synaptosomes, lysosomes, and beta-cell insulin granules provide charge neutralization support for the functionally indispensable acidification of the luminal interior...
Barg, Sebastian, Renström, Erik, Berggren, Per-Olof, Bertorello, Alejandro, Bokvist, Krister, Braun, Matthias, ...
Intracellular application of the sulfonylurea tolbutamide during whole-cell patch-clamp recordings stimulated exocytosis >5-fold when applied at a cytoplasmic Ca2+ concentration of 0.17 microM....
The voltage sensitive Lc-type Ca2+ channel is functionally coupled to the exocytotic machinery
Wiser, Ofer, Trus, Michael, Hernández, Ana, Renström, Erik, Barg, Sebastian, Rorsman, Patrik, ...
Although N- and P-type Ca2+ channels predominant in fast-secreting systems, Lc-type Ca2+ channels (C-class) can play a similar role in certain secretory cells and synapses. For example, in retinal...
Barg, Sebastian, Renström, Erik, Berggren, Per-Olof, Bertorello, Alejandro, Bokvist, Krister, Braun, Matthias, ...
Intracellular application of the sulfonylurea tolbutamide during whole-cell patch-clamp recordings stimulated exocytosis >5-fold when applied at a cytoplasmic Ca2+ concentration of 0.17 μM. This...
Impaired insulin secretion and glucose tolerance in β cell-selective CaV1.2 Ca2+ channel null mice
Schulla, Verena, Renström, Erik, Feil, Robert, Feil, Susanne, Franklin, Isobel, Gjinovci, Asllan, ...
Insulin is secreted from pancreatic β cells in response to an elevation of cytoplasmic Ca2+ resulting from enhanced Ca2+ influx through voltage-gated Ca2+ channels. Mouse β cells express several...
Sinnegger-Brauns, Martina J., Hetzenauer, Alfred, Huber, Irene G., Renström, Erik, Wietzorrek, Georg, Berjukov, Stanislav, ...
Cav1.2 and Cav1.3 L-type Ca2+ channels (LTCCs) are believed to underlie Ca2+ currents in brain, pancreatic β cells, and the cardiovascular system. In the CNS, neuronal LTCCs control...
CaV2.3 calcium channels control second-phase insulin release
Jing, Xingjun, Li, Dai-Qing, Olofsson, Charlotta S., Salehi, Albert, Surve, Vikas V., Caballero, José, ...
Concerted activation of different voltage-gated Ca2+ channel isoforms may determine the kinetics of insulin release from pancreatic islets. Here we have elucidated the role of R-type CaV2.3 channels...
The voltage sensitive Lc-type Ca2+ channel is functionally coupled to the exocytotic machinery
Wiser, Ofer, Trus, Michael, Hernández, Ana, Renström, Erik, Barg, Sebastian, Rorsman, Patrik, ...
Although N- and P-type Ca2+ channels predominant in fast-secreting systems, Lc-type Ca2+ channels (C-class) can play a similar role in certain secretory cells and synapses. For example, in retinal...
Barg, Sebastian, Renström, Erik, Berggren, Per-Olof, Bertorello, Alejandro, Bokvist, Krister, Braun, Matthias, ...
Intracellular application of the sulfonylurea tolbutamide during whole-cell patch-clamp recordings stimulated exocytosis >5-fold when applied at a cytoplasmic Ca2+ concentration of 0.17 μM. This...
Impaired insulin secretion and glucose tolerance in β cell-selective CaV1.2 Ca2+ channel null mice
Schulla, Verena, Renström, Erik, Feil, Robert, Feil, Susanne, Franklin, Isobel, Gjinovci, Asllan, ...
Insulin is secreted from pancreatic β cells in response to an elevation of cytoplasmic Ca2+ resulting from enhanced Ca2+ influx through voltage-gated Ca2+ channels. Mouse β cells express several...
Sinnegger-Brauns, Martina J., Hetzenauer, Alfred, Huber, Irene G., Renström, Erik, Wietzorrek, Georg, Berjukov, Stanislav, ...
Cav1.2 and Cav1.3 L-type Ca2+ channels (LTCCs) are believed to underlie Ca2+ currents in brain, pancreatic β cells, and the cardiovascular system. In the CNS, neuronal LTCCs control...
CaV2.3 calcium channels control second-phase insulin release
Jing, Xingjun, Li, Dai-Qing, Olofsson, Charlotta S., Salehi, Albert, Surve, Vikas V., Caballero, José, ...
Concerted activation of different voltage-gated Ca2+ channel isoforms may determine the kinetics of insulin release from pancreatic islets. Here we have elucidated the role of R-type CaV2.3 channels...
Gromada, Jesper, Høy, Marianne, Renström, Erik, Bokvist, Krister, Eliasson, Lena, Göpel, Sven, ...
Measurements of cell capacitance were used to investigate the mechanisms by which acetylcholine (ACh) stimulates Ca2+-induced exocytosis in single insulin-secreting mouse pancreatic B-cells.ACh (250...
SUR1 Regulates PKA-independent cAMP-induced Granule Priming in Mouse Pancreatic B-cells
Eliasson, Lena, Ma, Xiaosong, Renström, Erik, Barg, Sebastian, Berggren, Per-Olof, Galvanovskis, Juris, ...
Measurements of membrane capacitance were applied to dissect the cellular mechanisms underlying PKA-dependent and -independent stimulation of insulin secretion by cyclic AMP. Whereas the...
Göpel, Sven O., Kanno, Takahiro, Barg, Sebastian, Eliasson, Lena, Galvanovskis, Juris, Renström, Erik, ...
We have applied the perforated patch whole-cell technique to β cells within intact pancreatic islets to identify the current underlying the glucose-induced rhythmic firing of action potentials....
Gromada, Jesper, Bokvist, Krister, Ding, Wei-Guang, Barg, Sebastian, Buschard, Karsten, Renström, Erik, ...
We have monitored electrical activity, voltage-gated Ca2+ currents, and exocytosis in single rat glucagon-secreting pancreatic A-cells. The A-cells were electrically excitable and generated...
Why Treatment Fails in Type 2 Diabetes
Rosengren, Anders, Jing, Xingjun, Eliasson, Lena, Renström, Erik
Erik Renström and colleagues discuss a new mouse study that explores the mechanism behind the secondary failure of sulfonylurea treatment.