HIV-1 Vpr activates the G2checkpoint through manipulation of the ubiquitin proteasome system (2007)
DeHart, Jason L, Zimmerman, Erik S, Ardon, Orly, Monteiro-Filho, Carlos MR, Argañaraz, Enrique R, Planelles, Vicente
Abstract HIV-1 Vpr is a viral accessory protein that activates ATR through the induction of DNA replication stress. ATR activation results in cell cycle arrest in G 2 and induction of apoptosis. In...
HIV-1 Vpr-Induced Apoptosis Is Cell Cycle Dependent and Requires Bax but Not ANT (2006)
Joshua L. Andersen, Jason L. DeHart, Erik S. Zimmerman, Orly Ardon, Baek Kim, Guillaume Jacquot, ...
The HIV-1 accessory protein viral protein R (Vpr) causes G2 arrest and apoptosis in infected cells. We previously identified the DNA damage–signaling protein ATR as the cellular factor that...
Zimmerman, Erik S., Chen, Junjie, Andersen, Joshua L., Ardon, Orly, DeHart, Jason L., Blackett, Jana, ...
Eukaryotic cells have evolved a complex mechanism for sensing DNA damage during genome replication. Activation of this pathway prevents entry into mitosis to allow for either DNA repair or, in the...
The Ataxia Telangiectasia-Mutated and Rad3-Related Protein Is Dispensable for Retroviral Integration
DeHart, Jason L., Andersen, Joshua L., Zimmerman, Erik S., Ardon, Orly, An, Dong Sung, Blackett, Jana, ...
Integration into the host cell DNA is an essential part of the retroviral life cycle and is required for the productive replication of a retrovirus. Retroviral integration involves cleavage of the...
Lai, Maoyi, Zimmerman, Erik S., Planelles, Vicente, Chen, Junjie
The human immunodeficiency virus type 1 (HIV-1) protein Vpr (viral protein R) arrests cells in the G2 phase of the cell cycle, a process that requires activation of the ATR (ataxia-telangiectasia and...
Ardon, Orly, Zimmerman, Erik S., Andersen, Joshua L., DeHart, Jason L., Blackett, Jana, Planelles, Vicente
Cyclophilin A (CypA) is a member of a family of cellular proteins that share a peptidyl prolyl cis-trans isomerase (PPIase) activity. CypA was previously reported to be required for the biochemical...
Zimmerman, Erik S., Chen, Junjie, Andersen, Joshua L., Ardon, Orly, DeHart, Jason L., Blackett, Jana, ...
Eukaryotic cells have evolved a complex mechanism for sensing DNA damage during genome replication. Activation of this pathway prevents entry into mitosis to allow for either DNA repair or, in the...
The Ataxia Telangiectasia-Mutated and Rad3-Related Protein Is Dispensable for Retroviral Integration
DeHart, Jason L., Andersen, Joshua L., Zimmerman, Erik S., Ardon, Orly, An, Dong Sung, Blackett, Jana, ...
Integration into the host cell DNA is an essential part of the retroviral life cycle and is required for the productive replication of a retrovirus. Retroviral integration involves cleavage of the...
Lai, Maoyi, Zimmerman, Erik S., Planelles, Vicente, Chen, Junjie
The human immunodeficiency virus type 1 (HIV-1) protein Vpr (viral protein R) arrests cells in the G2 phase of the cell cycle, a process that requires activation of the ATR (ataxia-telangiectasia and...
Ardon, Orly, Zimmerman, Erik S., Andersen, Joshua L., DeHart, Jason L., Blackett, Jana, Planelles, Vicente
Cyclophilin A (CypA) is a member of a family of cellular proteins that share a peptidyl prolyl cis-trans isomerase (PPIase) activity. CypA was previously reported to be required for the biochemical...
HIV-1 Vpr-Induced Apoptosis Is Cell Cycle Dependent and Requires Bax but Not ANT
Andersen, Joshua L, DeHart, Jason L, Zimmerman, Erik S, Ardon, Orly, Kim, Baek, Jacquot, Guillaume, ...
The HIV-1 accessory protein viral protein R (Vpr) causes G2 arrest and apoptosis in infected cells. We previously identified the DNA damage–signaling protein ATR as the cellular factor that...
Human Immunodeficiency Virus Type 1 Vpr Induces DNA Replication Stress In Vitro and In Vivo▿
Zimmerman, Erik S., Sherman, Michael P., Blackett, Jana L., Neidleman, Jason A., Kreis, Christophe, Mundt, Pamela, ...
The human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) causes cell cycle arrest in G2. Vpr-expressing cells display the hallmarks of certain forms of DNA damage, specifically...
HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system
DeHart, Jason L, Zimmerman, Erik S, Ardon, Orly, Monteiro-Filho, Carlos MR, Argañaraz, Enrique R, Planelles, Vicente
HIV-1 Vpr is a viral accessory protein that activates ATR through the induction of DNA replication stress. ATR activation results in cell cycle arrest in G2 and induction of apoptosis. In the present...