Harris, Karen S., Casey, Joanne L., Coley, Andrew M., Masciantonio, Rosella, Sabo, Jennifer K., Keizer, David W., ...
Apical membrane antigen 1 (AMA1) is expressed in schizont-stage malaria parasites and sporozoites and is thought to be involved in the invasion of host red blood cells. AMA1 is an important vaccine...
Harris, Karen S., Casey, Joanne L., Coley, Andrew M., Masciantonio, Rosella, Sabo, Jennifer K., Keizer, David W., ...
Apical membrane antigen 1 (AMA1) is expressed in schizont-stage malaria parasites and sporozoites and is thought to be involved in the invasion of host red blood cells. AMA1 is an important vaccine...
Structural insights into the degradation of Mcl-1 induced by BH3 domains
Czabotar, Peter E., Lee, Erinna F., Van Delft, Mark F., Day, Catherine L., Smith, Brian J., Huang, David C. S., ...
Apoptosis is held in check by prosurvival proteins of the Bcl-2 family. The distantly related BH3-only proteins bind to and antagonize them, thereby promoting apoptosis. Whereas binding of the...
Lee, Erinna F., Czabotar, Peter E., Van Delft, Mark F., Michalak, Ewa M., Boyle, Michelle J., Willis, Simon N., ...
Like Bcl-2, Mcl-1 is an important survival factor for many cancers, its expression contributing to chemoresistance and disease relapse. However, unlike other prosurvival Bcl-2–like proteins, Mcl-1...
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax
Fletcher, Jamie I., Meusburger, Sarina, Hawkins, Christine J., Riglar, David T., Lee, Erinna F., Fairlie, W. Douglas, ...
A central issue in the control of apoptosis is whether its essential mediators Bax and Bak must be restrained by Bcl-2-like prosurvival relatives to prevent their damaging mitochondria and unleashing...