Ernest J. Mui

Triazine Inhibits Toxoplasma gondii Tachyzoites In Vitro and In Vivo

Mui, Ernest J., Jacobus, David, Milhous, Wilbur K., Schiehser, Guy, Hsu, Honghue, Roberts, Craig W., ...

The triazine WR99210 [4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(2,4,5-trichlorophenoxypropyloxy)-1,3,5 triazine] inhibits Toxoplasma gondii in vitro at nanomolar levels (P < 0.05). The 50% inhibitory...

Triazine Inhibits Toxoplasma gondii Tachyzoites In Vitro and In Vivo

Mui, Ernest J., Jacobus, David, Milhous, Wilbur K., Schiehser, Guy, Hsu, Honghue, Roberts, Craig W., ...

The triazine WR99210 [4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(2,4,5-trichlorophenoxypropyloxy)-1,3,5 triazine] inhibits Toxoplasma gondii in vitro at nanomolar levels (P < 0.05). The 50% inhibitory...

Novel Triazine JPC-2067-B Inhibits Toxoplasma gondii In Vitro and In Vivo

Mui, Ernest J., Schiehser, Guy A., Milhous, Wilbur K., Hsu, Honghue, Roberts, Craig W., Kirisits, Michael, ...

Toxoplasmosis is a neglected tropical disease, an emerging disease as well as a significant problem in developed countries causing a substantial health burden. Better medicines with less toxicity are...

Genetic and Epigenetic Factors at COL2A1 and ABCA4 Influence Clinical Outcome in Congenital Toxoplasmosis

Jamieson, Sarra E., De Roubaix, Lee-Anne, Cortina-Borja, Mario, Tan, Hooi Kuan, Mui, Ernest J., Cordell, Heather J., ...

Studies of Toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents

Muench, Stephen P., Prigge, Sean T., McLeod, Rima, Rafferty, John B., Kirisits, Michael J., Roberts, Craig W., ...

The crystal structures of T. gondii and P. falciparum ENR in complex with NAD+ and triclosan and of T. gondii ENR in an apo form have been solved to 2.6, 2.2 and 2.8 Å, respectively.