Exact model reduction of combinatorial reaction networks (2008)
Conzelmann, Holger, Fey, Dirk, Gilles, Ernst D
Abstract Background Receptors and scaffold proteins usually possess a high number of distinct binding domains inducing the formation of large multiprotein signaling complexes. Due to combinatorial...
A Logical Model Provides Insights into T Cell Receptor Signaling (2007)
Julio Saez-Rodriguez, Luca Simeoni, Jonathan A. Lindquist, Rebecca Hemenway, Ursula Bommhardt, Boerge Arndt, ...
Cellular decisions are determined by complex molecular interaction networks. Large-scale signaling networks are currently being reconstructed, but the kinetic parameters and quantitative data that...
Structural and functional analysis of cellular networks with CellNetAnalyzer (2007)
Klamt, Steffen, Saez-Rodriguez, Julio, Gilles, Ernst D
Abstract Background Mathematical modelling of cellular networks is an integral part of Systems Biology and requires appropriate software tools. An important class of methods in Systems Biology deals...
A methodology for the structural and functional analysis of signaling and regulatory networks (2006)
Klamt, Steffen, Saez-Rodriguez, Julio, Lindquist, Jonathan A, Simeoni, Luca, Gilles, Ernst D
Abstract Background Structural analysis of cellular interaction networks contributes to a deeper understanding of network-wide interdependencies, causal relationships, and basic functional...
Conzelmann, Holger, Saez-Rodriguez, Julio, Sauter, Thomas, Kholodenko, Boris N, Gilles, Ernst D
Abstract Background: Receptors and scaffold proteins possess a number of distinct domains and bind multiple partners. A common problem in modeling signaling systems arises from a combinatorial...
Conzelmann, Holger, Saez-Rodriguez, Julio, Sauter, Thomas, Kholodenko, Boris N., Gilles, Ernst D.
Background:Receptors and scaffold proteins possess a number of distinct domains and bind multiple partners. A common problem in modeling signaling systems arises from a combinatorial explosion of...
Kremling, Andreas, Fischer, Sophia, Gadkar, Kapil, Doyle, Francis J., Sauter, Thomas, Bullinger, Eric, ...
A benchmark problem is described for the reconstruction and analysis of biochemical networks given sampled experimental data. The growth of the organisms is described in a bioreactor in which one...
A methodology for the structural and functional analysis of signaling and regulatory networks
Klamt, Steffen, Saez-Rodriguez, Julio, Lindquist, Jonathan A, Simeoni, Luca, Gilles, Ernst D
Kremling, Andreas, Fischer, Sophia, Gadkar, Kapil, Doyle, Francis J., Sauter, Thomas, Bullinger, Eric, ...
A benchmark problem is described for the reconstruction and analysis of biochemical networks given sampled experimental data. The growth of the organisms is described in a bioreactor in which one...
A methodology for the structural and functional analysis of signaling and regulatory networks
Klamt, Steffen, Saez-Rodriguez, Julio, Lindquist, Jonathan A, Simeoni, Luca, Gilles, Ernst D
A Logical Model Provides Insights into T Cell Receptor Signaling
Saez-Rodriguez, Julio, Simeoni, Luca, Lindquist, Jonathan A, Hemenway, Rebecca, Bommhardt, Ursula, Arndt, Boerge, ...
Cellular decisions are determined by complex molecular interaction networks. Large-scale signaling networks are currently being reconstructed, but the kinetic parameters and quantitative data that...