Effect of Rising Chemotherapy Costs on the Cost Savings of Colorectal Cancer Screening (2009)
Lansdorp-Vogelaar, Iris, Van Ballegooijen, Marjolein, Zauber, Ann G., Habbema, J. Dik F., Kuipers, Ernst J.
Background Although colorectal cancer screening is cost-effective, it requires a considerable net investment by governments or insurance companies. If screening was cost saving, governments and...
Surgery is Indicated for Persistent Enterocutaneous Fistulizing Crohn’s Disease (2008)
Judith E. Baars, Ernst J. Kuipers, Herman Van Dekken
We describe a patient with Crohn’s disease who presented with a persistent enterocutaneous fistula. Colonoscopy showed no abnormalities in the terminal ileum and cecum. The patient was treated with...
Jeurnink, Suzanne M, Van Eijck, Casper HJ, Steyerberg, Ewout W, Kuipers, Ernst J, Siersema, Peter D
Abstract Background Gastrojejunostomy (GJJ) is the most commonly used palliative treatment modality for malignant gastric outlet obstruction. Recently, stent placement has been introduced as an...
Van Der Gaag, Niels A, De Castro, Steve MM, Rauws, Erik AJ, Bruno, Marco J, Van Eijck, Casper HJ, Kuipers, Ernst J, ...
Abstract Background Surgery in patients with obstructive jaundice caused by a periampullary (pancreas, papilla, distal bile duct) tumor is associated with a higher risk of postoperative complications...
Debets-Ossenkopp, Yvette J., Herscheid, Aryanna J., Pot, Raymond G. J., Kuipers, Ernst J., Kusters, Johannes G.
Successful treatment of Helicobacter pylori infection is becoming compromised by emerging resistance. We report the prevalence rates of H. pylori resistance to metronidazole, clarithromycin,...
Re: Helicobacter pylori and Atrophic Gastritis: Importance of the cagA Status (1996)
KUIPERS, ERNST J., MEUWISSEN, STEPHAN G. M., PÉREZ-PÉREZ, GUILLERMO I., BLASER, MARTIN J.
Re: Helicobacter pylori and Atrophic Gastritis: Importance of the cagA Status (1996)
KUIPERS, ERNST J., PÉREZ-PÉREZ, GUILLERMO I., BLASER, M. J., MEUWISSEN, STEPHAN G. M.
Helicobacter pylori and Atrophic Gastritis: Importance of the cagA Status (1995)
Kuipers, Ernst J., Pérez-Pérez, Guillermo I., Meuwissen, Stephan G. M., Blaser, Martin J.
Background: Infection with Helicobacter pylori is a major risk factor for the development of atrophic gastritis and gastric cancer. H. pylori strains can differ with respect to the presence of cagA...
Namavar, Ferry, Van Doorn, Leen-Jan, Durrani, Zarmina, Kuipers, Ernst J.
The vacA s and m genotypes and the presence of cagA and IS605 were determined in Helicobacter pylori strains from patients with mono- and multiple infections. Surprisingly, these genetic markers were...
Roosendaal, Robert, Vos, Jan H., Roumen, Thijs, Van Vugt, René, Cattoli, Giovanni, Bart, Aldert, ...
An association between (unculturable) gastrospirillum-like organisms (GLO) and ulcerative lesions in the pars oesophagea in stomachs of swine has been claimed. In dogs GLO detected by microscopy may...
Kuipers, Ernst J., Waidner, Barbara, Davies, Beverly J., De Vries, Nicolette, Penn, Charles W., ...
The nickel-containing enzyme urease is an essential colonization factor of the gastric pathogen Helicobacter pylori, as it allows the bacterium to survive the acidic conditions in the gastric mucosa....
Evidence for a Conjugation-Like Mechanism of DNA Transfer in Helicobacter pylori
Kuipers, Ernst J., Israel, Dawn A., Kusters, Johannes G., Blaser, Martin J.
Many strains of Helicobacter pylori are naturally competent for transformation in vitro. Since there is a high degree of genetic variation among H. pylori strains, we sought to determine whether...
16S rRNA Mutation-Mediated Tetracycline Resistance in Helicobacter pylori
Gerrits, Monique M., De Zoete, Marcel R., Arents, Niek L. A., Kuipers, Ernst J., Kusters, Johannes G.
Most Helicobacter pylori strains are susceptible to tetracycline, an antibiotic commonly used for the eradication of H. pylori. However, an increase in incidence of tetracycline resistance in H....
Poppelaars, Sophie W., Davies, Beverly J., Stoof, Jeroen, Bereswill, Stefan, Kist, Manfred, ...
The important human pathogen Helicobacter pylori requires the abundant expression and activity of its urease enzyme for colonization of the gastric mucosa. The transcription, expression, and activity...
Transcriptional Phase Variation of a Type III Restriction-Modification System in Helicobacter pylori
De Vries, Nicolette, Duinsbergen, Dirk, Kuipers, Ernst J., Pot, Raymond G. J., Wiesenekker, Patricia, Penn, Charles W., ...
Phase variation is important in bacterial pathogenesis, since it generates antigenic variation for the evasion of immune responses and provides a strategy for quick adaptation to environmental...
Effects of 16S rRNA Gene Mutations on Tetracycline Resistance in Helicobacter pylori
Gerrits, Monique M., Berning, Marco, Kuipers, Ernst J., Kusters, Johannes G.
The triple-base-pair 16S rDNA mutation AGA926-928→TTC mediates high-level tetracycline resistance in Helicobacter pylori. In contrast, single- and double-base-pair mutations mediated only low-level...
Kuipers, Ernst J., Stoof, Jeroen, Poppelaars, Sophie W., Kusters, Johannes G.
Although the adaptive mechanisms allowing the gastric pathogen Helicobacter pylori to survive acid shocks have been well documented, the mechanisms allowing growth at mildly acidic conditions (pH...
Ernst, Florian D., Homuth, Georg, Stoof, Jeroen, Mäder, Ulrike, Waidner, Barbara, Kuipers, Ernst J., ...
Maintaining iron homeostasis is a necessity for all living organisms, as free iron augments the generation of reactive oxygen species like superoxide anions, at the risk of subsequent lethal cellular...
Ernst, Florian D., Kuipers, Ernst J., Heijens, Angela, Sarwari, Roya, Stoof, Jeroen, Penn, Charles W., ...
The NikR protein is a nickel-dependent regulatory protein which is a member of the ribbon-helix-helix family of transcriptional regulators. The gastric pathogen Helicobacter pylori expresses a NikR...
Namavar, Ferry, Van Doorn, Leen-Jan, Durrani, Zarmina, Kuipers, Ernst J.
The vacA s and m genotypes and the presence of cagA and IS605 were determined in Helicobacter pylori strains from patients with mono- and multiple infections. Surprisingly, these genetic markers were...
Roosendaal, Robert, Vos, Jan H., Roumen, Thijs, Van Vugt, René, Cattoli, Giovanni, Bart, Aldert, ...
An association between (unculturable) gastrospirillum-like organisms (GLO) and ulcerative lesions in the pars oesophagea in stomachs of swine has been claimed. In dogs GLO detected by microscopy may...
Kuipers, Ernst J., Waidner, Barbara, Davies, Beverly J., De Vries, Nicolette, Penn, Charles W., ...
The nickel-containing enzyme urease is an essential colonization factor of the gastric pathogen Helicobacter pylori, as it allows the bacterium to survive the acidic conditions in the gastric mucosa....
Evidence for a Conjugation-Like Mechanism of DNA Transfer in Helicobacter pylori
Kuipers, Ernst J., Israel, Dawn A., Kusters, Johannes G., Blaser, Martin J.
Many strains of Helicobacter pylori are naturally competent for transformation in vitro. Since there is a high degree of genetic variation among H. pylori strains, we sought to determine whether...
16S rRNA Mutation-Mediated Tetracycline Resistance in Helicobacter pylori
Gerrits, Monique M., De Zoete, Marcel R., Arents, Niek L. A., Kuipers, Ernst J., Kusters, Johannes G.
Most Helicobacter pylori strains are susceptible to tetracycline, an antibiotic commonly used for the eradication of H. pylori. However, an increase in incidence of tetracycline resistance in H....
Poppelaars, Sophie W., Davies, Beverly J., Stoof, Jeroen, Bereswill, Stefan, Kist, Manfred, ...
The important human pathogen Helicobacter pylori requires the abundant expression and activity of its urease enzyme for colonization of the gastric mucosa. The transcription, expression, and activity...
Transcriptional Phase Variation of a Type III Restriction-Modification System in Helicobacter pylori
De Vries, Nicolette, Duinsbergen, Dirk, Kuipers, Ernst J., Pot, Raymond G. J., Wiesenekker, Patricia, Penn, Charles W., ...
Phase variation is important in bacterial pathogenesis, since it generates antigenic variation for the evasion of immune responses and provides a strategy for quick adaptation to environmental...
Effects of 16S rRNA Gene Mutations on Tetracycline Resistance in Helicobacter pylori
Gerrits, Monique M., Berning, Marco, Kuipers, Ernst J., Kusters, Johannes G.
The triple-base-pair 16S rDNA mutation AGA926-928→TTC mediates high-level tetracycline resistance in Helicobacter pylori. In contrast, single- and double-base-pair mutations mediated only low-level...
Kuipers, Ernst J., Stoof, Jeroen, Poppelaars, Sophie W., Kusters, Johannes G.
Although the adaptive mechanisms allowing the gastric pathogen Helicobacter pylori to survive acid shocks have been well documented, the mechanisms allowing growth at mildly acidic conditions (pH...
Ernst, Florian D., Homuth, Georg, Stoof, Jeroen, Mäder, Ulrike, Waidner, Barbara, Kuipers, Ernst J., ...
Maintaining iron homeostasis is a necessity for all living organisms, as free iron augments the generation of reactive oxygen species like superoxide anions, at the risk of subsequent lethal cellular...
Ernst, Florian D., Kuipers, Ernst J., Heijens, Angela, Sarwari, Roya, Stoof, Jeroen, Penn, Charles W., ...
The NikR protein is a nickel-dependent regulatory protein which is a member of the ribbon-helix-helix family of transcriptional regulators. The gastric pathogen Helicobacter pylori expresses a NikR...
Van Der Gaag, Niels A, De Castro, Steve MM, Rauws, Erik AJ, Bruno, Marco J, Van Eijck, Casper HJ, Kuipers, Ernst J, ...
Ernst, Florian D., Stoof, Jeroen, Horrevoets, Wannie M., Kuipers, Ernst J., Kusters, Johannes G.
The transition metal nickel plays an important role in gastric colonization and persistence of the important human pathogen Helicobacter pylori, as it is the cofactor of the abundantly produced acid...
Belzer, Clara, Kuipers, Ernst J., Kusters, Johannes G.
Persistent colonization of mucosal surfaces by bacteria in the mammalian host requires concerted expression of colonization factors, depending on the environmental conditions. Helicobacter hepaticus...
Stent versus gastrojejunostomy for the palliation of gastric outlet obstruction: a systematic review
Jeurnink, Suzanne M, Van Eijck, Casper HJ, Steyerberg, Ewout W, Kuipers, Ernst J, Siersema, Peter D
Pathogenesis of Helicobacter pylori Infection
Kusters, Johannes G., Kuipers, Ernst J.
Helicobacter pylori is the first formally recognized bacterial carcinogen and is one of the most successful human pathogens, as over half of the world's population is colonized with this...
Gastrointestinal Endoscopic Terminology Coding (GET-C): A WHO-Approved Extension of the ICD-10
Groenen, Marcel J.M., Hirs, Willem, Becker, Henk, Kuipers, Ernst J., Berge Henegouwen, Gerard P., Fockens, Paul, ...
Technological developments have greatly promoted interest in the use of computer systems for recording findings and images at endoscopy and creating databases. The aim of this study was to develop a...
Twenty-Four Hour Tonometry in Patients Suspected of Chronic Gastrointestinal Ischemia
Mensink, Peter B.F., Geelkerken, Robert H., Huisman, Ad B., Kuipers, Ernst J., Kolkman, Jeroen J.
Hunfeld, Nicole G, Mathot, Ron A, Touw, Daan J, Van Schaik, Ron H, Mulder, Paul G, Franck, Paul F, ...
New endoscopic techniques for obscure gastrointestinal bleeding
Den Ouden, Henk, Van Tuyl, SAC, Groenen, Marcel, Stolk, Mark FJ, Kuipers, Ernst J
The case of a postmenopausal woman with a congenital aortic stenosis is presented. She presented with severe iron deficiency anemia. After negative extensive gastrointestinal analysis, she was...
Bosma, Brenda M, Metselaar, Herold J, Nagtzaam, Nicole M A, De Haan, Roel, Mancham, Shanta, ...
Myeloid dendritic cells (MDC) play an important role in antigen-specific immunity and tolerance. In transplantation setting donor-derived MDC are a promising tool to realize donor-specific tolerance....
The Rotterdam Study: 2010 objectives and design update
Hofman, Albert, Breteler, Monique M. B., Van Duijn, Cornelia M., Janssen, Harry L. A., Krestin, Gabriel P., Kuipers, Ernst J., ...
The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic,...