The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer (2009)
Fernandez, Agustin F., Rosales, Cecilia, Lopez-Nieva, Pilar, Graña, Osvaldo, Ballestar, Esteban, Ropero, Santiago, ...
The natural history of cancers associated with virus exposure is intriguing, since only a minority of human tissues infected with these viruses inevitably progress to cancer. However, the molecular...
Aguilera, Oscar, Peña, Cristina, García, José Miguel, Larriba, María Jesús, Ordóñez-Morán, Paloma, Navarro, Diego, ...
The Wnt–β-catenin pathway is aberrantly activated in most colon cancers. DICKKOPF-1 (DKK-1) gene encodes an extracellular Wnt inhibitor that blocks the formation of signalling receptor complexes...
Espada, Jesús, Ballestar, Esteban, Santoro, Raffaella, Fraga, Mario F., Villar-Garea, Ana, Németh, Attila, ...
The nucleolus is the site of ribosome synthesis in the nucleus, whose integrity is essential. Epigenetic mechanisms are thought to regulate the activity of the ribosomal RNA (rRNA) gene copies, which...
Espada, Jesús, Ballestar, Esteban, Santoro, Raffaella, Fraga, Mario F., Villar-Garea, Ana, Németh, Attila, ...
The nucleolus is the site of ribosome synthesis in the nucleus, whose integrity is essential. Epigenetic mechanisms are thought to regulate the activity of the ribosomal RNA (rRNA) gene copies, which...
Transcriptional targets of the chromatin-remodelling factor SMARCA4/BRG1 in lung cancer cells (2005)
Medina, Pedro P., Carretero, Julian, Ballestar, Esteban, Angulo, Barbara, Lopez-Rios, Fernando, Esteller, Manel, ...
BRG1, also called SMARCA4, is the catalytic subunit of the SWI/SNF chromatin-remodelling complex and influences transcriptional regulation by disrupting histone–DNA contacts in an ATP-dependent...
Transcriptional targets of the chromatin-remodelling factor SMARCA4/BRG1 in lung cancer cells (2005)
Medina, Pedro P., Carretero, Julian, Ballestar, Esteban, Angulo, Barbara, Lopez-Rios, Fernando, Esteller, Manel, ...
BRG1, also called SMARCA4, is the catalytic subunit of the SWI/SNF chromatin-remodelling complex and influences transcriptional regulation by disrupting histone-DNA contacts in an ATP-dependent...
Fraga, Mario F., Ballestar, Esteban, Montoya, Guillermo, Taysavang, Panya, Wade, Paul A., Esteller, Manel
The methyl‐CpG binding domain (MBD) family of proteins was defined based on sequence similarity in their DNA binding domains. In light of their high degree of conservation, it is of inherent...
The impact of chromatin in human cancer: linking DNA methylation to gene silencing (2002)
Ballestar, Esteban, Esteller, Manel
For decades, chromatin was considered to be an inert structure whose only role was the compacting and confining of DNA inside the eukaryotic nucleus. However, tremendous progress in this field over...
Allele-specific histone lysine methylation marks regulatory regions at imprinted mouse genes
Fournier, Cécile, Goto, Yuji, Ballestar, Esteban, Delaval, Katia, Hever, Ann M., Esteller, Manel, ...
In different eukaryotic model systems, chromatin and gene expression are modulated by post-translational modification of histone tails. In this in vivo study, histone methylation and acetylation are...
Fraga, Mario F., Ballestar, Esteban, Montoya, Guillermo, Taysavang, Panya, Wade, Paul A., Esteller, Manel
The methyl-CpG binding domain (MBD) family of proteins was defined based on sequence similarity in their DNA binding domains. In light of their high degree of conservation, it is of inherent interest...
Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer
Ballestar, Esteban, Paz, Maria F., Valle, Laura, Wei, Susan, Fraga, Mario F., Espada, Jesus, ...
Methyl-CpG binding proteins (MBDs) mediate histone deacetylase-dependent transcriptional silencing at methylated CpG islands. Using chromatin immunoprecitation (ChIP) we have found that gene-specific...
Peinado, Hector, Ballestar, Esteban, Esteller, Manel, Cano, Amparo
The transcription factor Snail has been described as a direct repressor of E-cadherin expression during development and carcinogenesis; however, the specific mechanisms involved in this process...
E47 phosphorylation by p38 MAPK promotes MyoD/E47 association and muscle-specific gene transcription
Lluís, Frederic, Ballestar, Esteban, Suelves, Mònica, Esteller, Manel, Muñoz-Cánoves, Pura
Selective recognition of the E-box sequences on muscle gene promoters by heterodimers of myogenic basic helix–loop–helix (bHLH) transcription factors, such as MyoD, with the ubiquitous bHLH...
Epigenetic differences arise during the lifetime of monozygotic twins
Fraga, Mario F., Ballestar, Esteban, Paz, Maria F., Ropero, Santiago, Setien, Fernando, Ballestar, Maria L., ...
Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to...
Allele-specific histone lysine methylation marks regulatory regions at imprinted mouse genes
Fournier, Cécile, Goto, Yuji, Ballestar, Esteban, Delaval, Katia, Hever, Ann M., Esteller, Manel, ...
In different eukaryotic model systems, chromatin and gene expression are modulated by post-translational modification of histone tails. In this in vivo study, histone methylation and acetylation are...
Fraga, Mario F., Ballestar, Esteban, Montoya, Guillermo, Taysavang, Panya, Wade, Paul A., Esteller, Manel
The methyl-CpG binding domain (MBD) family of proteins was defined based on sequence similarity in their DNA binding domains. In light of their high degree of conservation, it is of inherent interest...
Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer
Ballestar, Esteban, Paz, Maria F., Valle, Laura, Wei, Susan, Fraga, Mario F., Espada, Jesus, ...
Methyl-CpG binding proteins (MBDs) mediate histone deacetylase-dependent transcriptional silencing at methylated CpG islands. Using chromatin immunoprecitation (ChIP) we have found that gene-specific...
Peinado, Hector, Ballestar, Esteban, Esteller, Manel, Cano, Amparo
The transcription factor Snail has been described as a direct repressor of E-cadherin expression during development and carcinogenesis; however, the specific mechanisms involved in this process...
E47 phosphorylation by p38 MAPK promotes MyoD/E47 association and muscle-specific gene transcription
Lluís, Frederic, Ballestar, Esteban, Suelves, Mònica, Esteller, Manel, Muñoz-Cánoves, Pura
Selective recognition of the E-box sequences on muscle gene promoters by heterodimers of myogenic basic helix–loop–helix (bHLH) transcription factors, such as MyoD, with the ubiquitous bHLH...
Epigenetic differences arise during the lifetime of monozygotic twins
Fraga, Mario F., Ballestar, Esteban, Paz, Maria F., Ropero, Santiago, Setien, Fernando, Ballestar, Maria L., ...
Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to...
Espada, Jesús, Ballestar, Esteban, Santoro, Raffaella, Fraga, Mario F., Villar-Garea, Ana, Németh, Attila, ...
The nucleolus is the site of ribosome synthesis in the nucleus, whose integrity is essential. Epigenetic mechanisms are thought to regulate the activity of the ribosomal RNA (rRNA) gene copies, which...
Perdiguero, Eusebio, Ruiz-Bonilla, Vanessa, Gresh, Lionel, Hui, Lijian, Ballestar, Esteban, Sousa-Victor, Pedro, ...
The p38 mitogen-activated protein kinase (MAPK) pathway plays a critical role in skeletal muscle differentiation. However, the relative contribution of the four p38 MAPKs (p38α, p38β, p38γ and...
Promoter DNA Hypermethylation and Gene Repression in Undifferentiated Arabidopsis Cells
Berdasco, María, Alcázar, Rubén, García-Ortiz, María Victoria, Ballestar, Esteban, Fernández, Agustín F., Roldán-Arjona, Teresa, ...
Maintaining and acquiring the pluripotent cell state in plants is critical to tissue regeneration and vegetative multiplication. Histone-based epigenetic mechanisms are important for regulating this...
The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer
Fernandez, Agustin F., Rosales, Cecilia, Lopez-Nieva, Pilar, Graña, Osvaldo, Ballestar, Esteban, Ropero, Santiago, ...
The natural history of cancers associated with virus exposure is intriguing, since only a minority of human tissues infected with these viruses inevitably progress to cancer. However, the molecular...
González-García, Sara, García-Peydró, Marina, Martín-Gayo, Enrique, Ballestar, Esteban, Esteller, Manel, Bornstein, Rafael, ...
Notch1 activation is essential for T-lineage specification of lymphomyeloid progenitors seeding the thymus. Progression along the T cell lineage further requires cooperative signaling provided by the...