Ethan Lee, Adrian Salic, Roland Krüger, Reinhart Heinrich, Marc W. Kirschner
Wnt signaling is important in both oncogenesis and development. Mathematical modeling predicts several unusual features of the Wnt pathway, some of which are tested experimentally.
Ethan Lee, Adrian Salic, Roland Krüger, Reinhart Heinrich, Marc W. Kirschner
Wnt signaling plays an important role in both oncogenesis and development. Activation of the Wnt pathway results in stabilization of the transcriptional coactivator β-catenin. Recent studies have...
Ethan Lee, Adrian Salic, Reinhart Heinrich, Marc W. Kirschner
Wnt signaling plays an important role in both oncogenesis and development. Activation of the Wnt pathway results in stabilization of the transcriptional coactivator b-catenin. Recent studies have...
The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway
Lee, Ethan, Salic, Adrian, Krüger, Roland, Heinrich, Reinhart, Kirschner, Marc W
Wnt signaling plays an important role in both oncogenesis and development. Activation of the Wnt pathway results in stabilization of the transcriptional coactivator β-catenin. Recent studies have...
Inhibition of Cdh1–APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1
Pfleger, Cathie M., Salic, Adrian, Lee, Ethan, Kirschner, Marc W.
Exit from mitosis requires the degradation of regulatory proteins including the mitotic cyclins and securin through ubiquitination by the anaphase promoting complex (APC) bound to Cdc20 or Cdh1....
Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex
Pfleger, Cathie M., Lee, Ethan, Kirschner, Marc W.
The specificity of ubiquitin-mediated protein degradation with regards to the selection of substrates to be polyubiquitinated has only been determined rather recently. Substrate targeting by the...
The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway
Lee, Ethan, Salic, Adrian, Krüger, Roland, Heinrich, Reinhart, Kirschner, Marc W
Wnt signaling plays an important role in both oncogenesis and development. Activation of the Wnt pathway results in stabilization of the transcriptional coactivator β-catenin. Recent studies have...
Inhibition of Cdh1–APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1
Pfleger, Cathie M., Salic, Adrian, Lee, Ethan, Kirschner, Marc W.
Exit from mitosis requires the degradation of regulatory proteins including the mitotic cyclins and securin through ubiquitination by the anaphase promoting complex (APC) bound to Cdc20 or Cdh1....
Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex
Pfleger, Cathie M., Lee, Ethan, Kirschner, Marc W.
The specificity of ubiquitin-mediated protein degradation with regards to the selection of substrates to be polyubiquitinated has only been determined rather recently. Substrate targeting by the...
Physiological regulation of β-catenin stability by Tcf3 and CK1ε
Lee, Ethan, Salic, Adrian, Kirschner, Marc W.
The wnt pathway regulates the steady state level of β-catenin, a transcriptional coactivator for the Tcf3/Lef1 family of DNA binding proteins. We demonstrate that Tcf3 can inhibit β-catenin...
Moore, Amy C., Amann, Joseph M., Williams, Christopher S., Tahinci, Emilios, Farmer, Tiffany E., Martinez, J. Andres, ...
Canonical Wnt signaling is mediated by a molecular “switch” that regulates the transcriptional properties of the T-cell factor (TCF) family of DNA-binding proteins. Members of the myeloid...
Cselenyi, Christopher S., Jernigan, Kristin K., Tahinci, Emilios, Thorne, Curtis A., Lee, Laura A., Lee, Ethan
Wnt/β-catenin signaling controls various cell fates in metazoan development and is misregulated in several cancers and developmental disorders. Binding of a Wnt ligand to its transmembrane...
Alfaro, Maria P., Pagni, Matthew, Vincent, Alicia, Atkinson, James, Hill, Michael F., Cates, Justin, ...
Cell-based therapies, using multipotent mesenchymal stem cells (MSCs) for organ regeneration, are being pursued for cardiac disease, orthopedic injuries and biomaterial fabrication. The molecular...
asunder Is a Critical Regulator of Dynein–Dynactin Localization during Drosophila Spermatogenesis
Anderson, Michael A., Jodoin, Jeanne N., Lee, Ethan, Hales, Karen G., Hays, Thomas S., Lee, Laura A.
Spermatogenesis uses mitotic and meiotic cell cycles coordinated with growth and differentiation programs to generate functional sperm. Our analysis of a Drosophila mutant has revealed that asunder...