Hao, Ke, Chudin, Eugene, McElwee, Joshua, Schadt, Eric E
Abstract Background Although high-throughput genotyping arrays have made whole-genome association studies (WGAS) feasible, only a small proportion of SNPs in the human genome are actually surveyed in...
Common body mass index-associated variants confer risk of extreme obesity (2009)
Cotsapas, Chris, Speliotes, Elizabeth K., Hatoum, Ida J., Greenawalt, Danielle M., Dobrin, Radu, Lum, Pek Y., ...
To investigate the genetic architecture of severe obesity, we performed a genome-wide association study of 775 cases and 3197 unascertained controls at ∼550 000 markers across the autosomal genome....
Mapping the Genetic Architecture of Gene Expression in Human Liver (2008)
Eric E. Schadt, Cliona Molony, Eugene Chudin, Ke Hao, Xia Yang, Pek Y. Lum, ...
Genetic variants that are associated with common human diseases do not lead directly to disease, but instead act on intermediate, molecular phenotypes that in turn induce changes in higher-order...
David Serre, Scott Gurd, Bing Ge, Robert Sladek, Donna Sinnett, Eef Harmsen, ...
The recent development of whole genome association studies has lead to the robust identification of several loci involved in different common human diseases. Interestingly, some of the strongest...
Liu, Ying, Shin, Soojung, Zeng, Xianmin, Zhan, Ming, Gonzalez, Rodolfo, Mueller, Franz-Josef, ...
Abstract Background In order to compare the gene expression profiles of human embryonic stem cell (hESC) lines and their differentiated progeny and to monitor feeder contaminations, we have examined...
High-throughput DNA methylation profiling using universal bead arrays (2006)
Bibikova, Marina, Lin, Zhenwu, Zhou, Lixin, Chudin, Eugene, Garcia, Eliza Wickham, Wu, Bonnie, ...
We have developed a high-throughput method for analyzing the methylation status of hundreds of preselected genes simultaneously and have applied it to the discovery of methylation signatures that...
Human embryonic stem cells have a unique epigenetic signature (2006)
Bibikova, Marina, Chudin, Eugene, Wu, Bonnie, Zhou, Lixin, Garcia, Eliza Wickham, Liu, Ying, ...
Human embryonic stem (hES) cells originate during an embryonic period of active epigenetic remodeling. DNA methylation patterns are likely to be critical for their self-renewal and pluripotence. We...
High-throughput DNA methylation profiling using universal bead arrays (2006)
Bibikova, Marina, Lin, Zhenwu, Zhou, Lixin, Chudin, Eugene, Garcia, Eliza Wickham, Wu, Bonnie, ...
We have developed a high-throughput method for analyzing the methylation status of hundreds of preselected genes simultaneously and have applied it to the discovery of methylation signatures that...
Human embryonic stem cells have a unique epigenetic signature (2006)
Bibikova, Marina, Chudin, Eugene, Wu, Bonnie, Zhou, Lixin, Wickham Garcia, Eliza, Liu, Ying, ...
Human embryonic stem (hES) cells originate during an embryonic period of active epigenetic remodeling. DNA methylation patterns are likely to be critical for their self-renewal and pluripotence. We...
A novel, high-performance random array platform for quantitative gene expression profiling (2004)
Kuhn, Kenneth, Baker, Shawn C., Chudin, Eugene, Lieu, Minh-Ha, Oeser, Steffen, Bennett, Holly, ...
We have developed a new microarray technology for quantitative gene-expression profiling on the basis of randomly assembled arrays of beads. Each bead carries a gene-specific probe sequence. There...
A Versatile Assay for High-Throughput Gene Expression Profiling on Universal Array Matrices (2004)
Fan, Jian-Bing, Yeakley, Joanne M., Bibikova, Marina, Chudin, Eugene, Wickham, Eliza, Chen, Jing, ...
We report a flexible, sensitive, and quantitative gene-expression profiling system for assaying more than 400 genes, with three probes per gene, for 96 samples in parallel. The cDNA-mediated...
Chudin, Eugene, Walker, Randal, Kosaka, Alan, Wu, Sue X, Rabert, Douglas, Chang, Thomas K, ...
Abstract Background Affymetrix microarrays have become increasingly popular in gene-expression studies; however, limitations of the technology have not been well established for commercially...
Typescript (photocopy).
Chudin, Eugene, Walker, Randal, Kosaka, Alan, Wu, Sue X, Rabert, Douglas, Chang, Thomas K, ...
Affymetrix microarrays have been shown to give a signal proportional to actual transcript concentration, to distinguish concentration levels within a factor of 2, and to detect transcript frequencies...
A Versatile Assay for High-Throughput Gene Expression Profiling on Universal Array Matrices
Fan, Jian-Bing, Yeakley, Joanne M., Bibikova, Marina, Chudin, Eugene, Wickham, Eliza, Chen, Jing, ...
We report a flexible, sensitive, and quantitative gene-expression profiling system for assaying more than 400 genes, with three probes per gene, for 96 samples in parallel. The cDNA-mediated...
A novel, high-performance random array platform for quantitative gene expression profiling
Kuhn, Kenneth, Baker, Shawn C., Chudin, Eugene, Lieu, Minh-Ha, Oeser, Steffen, Bennett, Holly, ...
We have developed a new microarray technology for quantitative gene-expression profiling on the basis of randomly assembled arrays of beads. Each bead carries a gene-specific probe sequence. There...
High-throughput DNA methylation profiling using universal bead arrays
Bibikova, Marina, Lin, Zhenwu, Zhou, Lixin, Chudin, Eugene, Garcia, Eliza Wickham, Wu, Bonnie, ...
We have developed a high-throughput method for analyzing the methylation status of hundreds of preselected genes simultaneously and have applied it to the discovery of methylation signatures that...
Chudin, Eugene, Walker, Randal, Kosaka, Alan, Wu, Sue X, Rabert, Douglas, Chang, Thomas K, ...
Affymetrix microarrays have been shown to give a signal proportional to actual transcript concentration, to distinguish concentration levels within a factor of 2, and to detect transcript frequencies...
A Versatile Assay for High-Throughput Gene Expression Profiling on Universal Array Matrices
Fan, Jian-Bing, Yeakley, Joanne M., Bibikova, Marina, Chudin, Eugene, Wickham, Eliza, Chen, Jing, ...
We report a flexible, sensitive, and quantitative gene-expression profiling system for assaying more than 400 genes, with three probes per gene, for 96 samples in parallel. The cDNA-mediated...
A novel, high-performance random array platform for quantitative gene expression profiling
Kuhn, Kenneth, Baker, Shawn C., Chudin, Eugene, Lieu, Minh-Ha, Oeser, Steffen, Bennett, Holly, ...
We have developed a new microarray technology for quantitative gene-expression profiling on the basis of randomly assembled arrays of beads. Each bead carries a gene-specific probe sequence. There...
High-throughput DNA methylation profiling using universal bead arrays
Bibikova, Marina, Lin, Zhenwu, Zhou, Lixin, Chudin, Eugene, Garcia, Eliza Wickham, Wu, Bonnie, ...
We have developed a high-throughput method for analyzing the methylation status of hundreds of preselected genes simultaneously and have applied it to the discovery of methylation signatures that...
Human embryonic stem cells have a unique epigenetic signature
Bibikova, Marina, Chudin, Eugene, Wu, Bonnie, Zhou, Lixin, Garcia, Eliza Wickham, Liu, Ying, ...
Human embryonic stem (hES) cells originate during an embryonic period of active epigenetic remodeling. DNA methylation patterns are likely to be critical for their self-renewal and pluripotence. We...
Bibikova, Marina, Talantov, Dimitri, Chudin, Eugene, Yeakley, Joanne M., Chen, Jing, Doucet, Dennis, ...
We recently developed a sensitive and flexible gene expression profiling system that is not dependent on an intact poly-A tail and showed that it could be used to analyze degraded RNA samples. We...
Serre, David, Gurd, Scott, Ge, Bing, Sladek, Robert, Sinnett, Donna, Harmsen, Eef, ...
The recent development of whole genome association studies has lead to the robust identification of several loci involved in different common human diseases. Interestingly, some of the strongest...
Mapping the Genetic Architecture of Gene Expression in Human Liver
Schadt, Eric E, Molony, Cliona, Chudin, Eugene, Hao, Ke, Yang, Xia, Lum, Pek Y, ...
Genetic variants that are associated with common human diseases do not lead directly to disease, but instead act on intermediate, molecular phenotypes that in turn induce changes in higher-order...