Hiroyuki Nakai, Xiaolin Wu, Sally Fuess, Theresa A. Storm, David Munroe, Eugenio Montini, ...
Recombinant adeno-associated virus (rAAV) vector holds promise for gene therapy. Despite a low frequency of chromosomal integration of vector genomes, recent studies have raised concerns about the...
Large-Scale Molecular Characterization of Adeno-Associated Virus Vector Integration in Mouse Liver
Nakai, Hiroyuki, Wu, Xiaolin, Fuess, Sally, Storm, Theresa A., Munroe, David, Montini, Eugenio, ...
Recombinant adeno-associated virus (rAAV) vector holds promise for gene therapy. Despite a low frequency of chromosomal integration of vector genomes, recent studies have raised concerns about the...
Large-Scale Molecular Characterization of Adeno-Associated Virus Vector Integration in Mouse Liver
Nakai, Hiroyuki, Wu, Xiaolin, Fuess, Sally, Storm, Theresa A., Munroe, David, Montini, Eugenio, ...
Recombinant adeno-associated virus (rAAV) vector holds promise for gene therapy. Despite a low frequency of chromosomal integration of vector genomes, recent studies have raised concerns about the...
Kinetics of Liver Repopulation after Bone Marrow Transplantation
Wang, Xin, Montini, Eugenio, Al-Dhalimy, Muhsen, Lagasse, Eric, Finegold, Milton, Grompe, Markus
Recent work has convincingly demonstrated that adult bone marrow contains cells capable of differentiating into liver epithelial cells in vivo. However, the frequency and time course with which fully...
Targeted inactivation of the COP9 signalosome impairs multiple stagesof T cell development
Panattoni, Martina, Sanvito, Francesca, Basso, Veronica, Doglioni, Claudio, Casorati, Giulia, Montini, Eugenio, ...
Genetic programs promoting cell cycle progression, DNA repair, and survival are coordinately induced in developing T cells and require rapid turnover of effector molecules. As the COP9 signalosome...
Gonzalez-Murillo, Africa, Lozano, M. Luz, Montini, Eugenio, Bueren, Juan A., Guenechea, Guillermo
Recent studies of retroviral-mediated gene transfer have shown that retroviral integrations themselves may trigger nonmalignant clonal expansion of hematopoietic stem cells (HSCs) in transplant...
Montini, Eugenio, Cesana, Daniela, Schmidt, Manfred, Sanvito, Francesca, Bartholomae, Cynthia C., Ranzani, Marco, ...
γ-Retroviral vectors (γRVs), which are commonly used in gene therapy, can trigger oncogenesis by insertional mutagenesis. Here, we have dissected the contribution of vector design and viral...