Eui-Cheol Shin

Inhibition of Epstein-Barr virus-induced growth proliferation by a nuclear antigen EBNA2-TAT peptide

Farrell, Christopher J., Lee, Jae Myun, Shin, Eui-Cheol, Cebrat, Marek, Cole, Philip A., Hayward, S. Diane

Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with cancers in immunocompromised populations. Antiviral drugs targeted against lytic viral replication have limited...

Liver-Directed Gamma Interferon Gene Delivery in Chronic Hepatitis C

Shin, Eui-Cheol, Protzer, Ulrike, Untergasser, Andreas, Feinstone, Stephen M., Rice, Charles M., Hasselschwert, Dana, ...

Gamma interferon (IFN-γ) has been shown to inhibit replication of subgenomic and genomic hepatitis C virus (HCV) RNAs in vitro and to noncytolytically suppress hepatitis B virus (HBV) replication in...

Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection

Shin, Eui-Cheol, Seifert, Ulrike, Kato, Takanobu, Rice, Charles M., Feinstone, Stephen M., Kloetzel, Peter-M., ...

IFN-γ is known as the initial and primary inducer of immunoproteasomes during viral infections. We now report that type I IFN induced the transcription and translation of immunoproteasome subunits,...

Inhibition of Epstein-Barr virus-induced growth proliferation by a nuclear antigen EBNA2-TAT peptide

Farrell, Christopher J., Lee, Jae Myun, Shin, Eui-Cheol, Cebrat, Marek, Cole, Philip A., Hayward, S. Diane

Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with cancers in immunocompromised populations. Antiviral drugs targeted against lytic viral replication have limited...

Liver-Directed Gamma Interferon Gene Delivery in Chronic Hepatitis C

Shin, Eui-Cheol, Protzer, Ulrike, Untergasser, Andreas, Feinstone, Stephen M., Rice, Charles M., Hasselschwert, Dana, ...

Gamma interferon (IFN-γ) has been shown to inhibit replication of subgenomic and genomic hepatitis C virus (HCV) RNAs in vitro and to noncytolytically suppress hepatitis B virus (HBV) replication in...

Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection

Shin, Eui-Cheol, Seifert, Ulrike, Kato, Takanobu, Rice, Charles M., Feinstone, Stephen M., Kloetzel, Peter-M., ...

IFN-γ is known as the initial and primary inducer of immunoproteasomes during viral infections. We now report that type I IFN induced the transcription and translation of immunoproteasome subunits,...

Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C

Manigold, Tobias, Shin, Eui-Cheol, Mizukoshi, Eishiro, Mihalik, Kathleen, Murthy, Krishna K., Rice, Charles M., ...

Hepatitis C virus (HCV) poses a global health problem because it readily establishes persistent infection and a vaccine is not available. CD4+CD25+ T cells have been implicated in HCV persistence...

Private aspects of heterologous immunity

Rehermann, Barbara, Shin, Eui-Cheol

Clinical manifestations of viral infections are highly variable, both in type and severity, among individual patients. Differences in host genetics and in dose and route of infection contribute to...

The Kinetics of Hepatitis C Virus-Specific CD8 T-Cell Responses in the Blood Mirror Those in the Liver in Acute Hepatitis C Virus Infection▿

Shin, Eui-Cheol, Capone, Stefania, Cortese, Riccardo, Colloca, Stefano, Nicosia, Alfredo, Folgori, Antonella, ...

Peripheral blood T-cell responses are used as biomarkers in hepatitis C virus (HCV) vaccine trials. However, it is not clear how T-cell responses in the blood correlate with those in the liver, the...