Development of Tau Aggregation Inhibitors for Alzheimer's Disease (2009)
Bulic, Bruno, Pickhardt, Marcus, Schmidt, Boris, Mandelkow, Eva-Maria, Waldmann, Herbert, Mandelkow, Eckhard
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing (2009)
Wang, Yipeng, Martinez-Vicente, Marta, Krüger, Ulrike, Kaushik, Susmita, Wong, Esther, Mandelkow, Eva-Maria, ...
Aggregation and cleavage are two hallmarks of Tau pathology in Alzheimer disease (AD), and abnormal fragmentation of Tau is thought to contribute to the nucleation of Tau paired helical filaments....
Timm, Thomas, Marx, Alexander, Panneerselvam, Saravanan, Mandelkow, Eckhard, Mandelkow, Eva-Maria
Abstract Protein kinases of the MARK family phosphorylate tau protein in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired...
Rhodanine-Based Tau Aggregation Inhibitors in Cell Models of Tauopathy (2007)
Bulic, Bruno, Pickhardt, Marcus, Khlistunova, Inna, Biernat, Jacek, Mandelkow, Eva-Maria, Mandelkow, Eckhard, ...
Rhodanine-Based Tau Aggregation Inhibitors in Cell Models of Tauopathy (2007)
Bulic, Bruno, Pickhardt, Marcus, Khlistunova, Inna, Biernat, Jacek, Mandelkow, Eva-Maria, Mandelkow, Eckhard, ...
The structure of motor-MAP-microtubule interactions (2006)
Marx, Alexander, Müller, Jens, Mandelkow, Eva-Maria, Hoenger, Andreas, Mandelkow, Eckhard
MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons (2004)
Mandelkow, Eva-Maria, Thies, Edda, Trinczek, Bernhard, Biernat, Jacek, Mandelkow, Eckhard
Surface-decoration of Microtubules by Human Tau (2004)
Santarella, Rachel A., Skiniotis, Georgios, Goldie, Kenneth N., Tittmann, Peter, Gross, Heinz, Mandelkow, Eva-Maria, ...
Hyperphosphorylation and Aggregation of Tau in Experimental Autoimmune Encephalomyelitis (2004)
Schneider, Anja, Wright-Araujo, Gilda, Trajkovic, Katarina, Herrmann, Martin M., Merkler, Doron, Mandelkow, Eva-Maria, ...
Pickhardt, Marcus, Gazova, Zuzana, Von Bergen, Martin, Khlistunova, Inna, Wang, Yipeng, Hascher, Antje, ...
Augustinack, Jean C., Schneider, Anja, Mandelkow, Eva-Maria, Hyman, Bradley T.
Microtubule associated protein tau is abnormally phosphorylated in Alzheimer's disease (AD) and aggregates as paired helical filaments (PHFs) in neurofibrillary tangles (NFTs). We show here that the...
Single-molecule investigation of the interference between kinesin, tau and MAP2c (2002)
Seitz, Arne, Kojima, Hiroaki, Oiwa, Kazuhiro, Mandelkow, Eva-Maria, Song, Young-Hwa, Mandelkow, Eckhard
Motor proteins and microtubule-associated proteins (MAPs) play important roles in cellular transport, regulation of shape and polarity of cells. While motor proteins generate motility, MAPs are...
Biernat, Jacek, Wu, Yong-Zhong, Timm, Thomas, Zheng-Fischhöfer, Qingyi, Mandelkow, Eckhard, Meijer, Laurent, ...
Protein kinases of the microtubule affinity-regulating kinase (MARK) family were originally discovered because of their ability to phosphorylate certain sites in tau protein (KXGS motifs in the...
Li, Li, Von Bergen, Martin, Mandelkow, Eva-Maria, Mandelkow, Eckhard
By using tryptophan scanning mutagenesis, we observed the kinetics and structure of the polymerization of tau into paired helical filaments (PHFs) independently of exogenous reporter dyes. The...
Kinesin motors and disease (2002)
Mandelkow, Eckhard, Mandelkow, Eva-Maria
Kinesins are motor proteins that move cargoes such as vesicles, organelles and chromosomes along microtubules. They are best known for their role in axonal transport and in mitosis. There is a...
Fluorimetrische Untersuchungen zur Reaktionskinetik des Myosins. (1973)
Heidelberg, Univ., Med. Fak., Diss. 1974. (Nicht f. d. Austausch.).
Biernat, Jacek, Mandelkow, Eva-Maria
The differentiation of neurons and the outgrowth of neurites depends on microtubule-associated proteins such as tau protein. To study this process, we have used the model of Sf9 cells, which allows...
Illenberger, Susanne, Zheng-Fischhöfer, Qingyi, Preuss, Ute, Stamer, Karsten, Baumann, Karlheinz, Trinczek, Bernhard, ...
In Alzheimer’s disease the neuronal microtubule-associated protein tau becomes highly phosphorylated, loses its binding properties, and aggregates into paired helical filaments. There is increasing...
Single-molecule investigation of the interference between kinesin, tau and MAP2c
Seitz, Arne, Kojima, Hiroaki, Oiwa, Kazuhiro, Mandelkow, Eva-Maria, Song, Young-Hwa, Mandelkow, Eckhard
Motor proteins and microtubule-associated proteins (MAPs) play important roles in cellular transport, regulation of shape and polarity of cells. While motor proteins generate motility, MAPs are...
Protein Kinase MARK/PAR-1 Is Required for Neurite Outgrowth and Establishment of Neuronal Polarity
Biernat, Jacek, Wu, Yong-Zhong, Timm, Thomas, Zheng-Fischhöfer, Qingyi, Mandelkow, Eckhard, Meijer, Laurent, ...
Protein kinases of the microtubule affinity-regulating kinase (MARK) family were originally discovered because of their ability to phosphorylate certain sites in tau protein (KXGS motifs in the...
MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1
Timm, Thomas, Li, Xiao-Yu, Biernat, Jacek, Jiao, Jian, Mandelkow, Eckhard, Vandekerckhove, Joel, ...
MARK, a kinase family related to PAR-1 involved in establishing cell polarity, phosphorylates microtubule-associated proteins (tau/MAP2/MAP4) at KXGS motifs, causes detachment from microtubules, and...
PAK5 Kinase Is an Inhibitor of MARK/Par-1, Which Leads to Stable Microtubules and Dynamic ActinD⃞
Matenia, Dorthe, Griesshaber, Bettina, Li, Xiao-yu, Thiessen, Anja, Johne, Cindy, Jiao, Jian, ...
MARK/Par-1 is a kinase involved in development of embryonic polarity. In neurons, MARK phosphorylates tau protein and causes its detachment from microtubules, the tracks of axonal transport. Because...
Inhibition of APP Trafficking by Tau Protein Does Not Increase the Generation of Amyloid-β Peptides
Goldsbury, Claire, Mocanu, Maria-Magdalena, Thies, Edda, Kaether, Christoph, Haass, Christian, Keller, Patrick, ...
Amyloid-β, a peptide derived from the precursor protein APP, accumulates in the brain and contributes to the neuropathology of Alzheimer's disease. Increased generation of amyloid-β might be caused...
Biernat, Jacek, Mandelkow, Eva-Maria
The differentiation of neurons and the outgrowth of neurites depends on microtubule-associated proteins such as tau protein. To study this process, we have used the model of Sf9 cells, which allows...
Illenberger, Susanne, Zheng-Fischhöfer, Qingyi, Preuss, Ute, Stamer, Karsten, Baumann, Karlheinz, Trinczek, Bernhard, ...
In Alzheimer’s disease the neuronal microtubule-associated protein tau becomes highly phosphorylated, loses its binding properties, and aggregates into paired helical filaments. There is increasing...
Single-molecule investigation of the interference between kinesin, tau and MAP2c
Seitz, Arne, Kojima, Hiroaki, Oiwa, Kazuhiro, Mandelkow, Eva-Maria, Song, Young-Hwa, Mandelkow, Eckhard
Motor proteins and microtubule-associated proteins (MAPs) play important roles in cellular transport, regulation of shape and polarity of cells. While motor proteins generate motility, MAPs are...
Protein Kinase MARK/PAR-1 Is Required for Neurite Outgrowth and Establishment of Neuronal Polarity
Biernat, Jacek, Wu, Yong-Zhong, Timm, Thomas, Zheng-Fischhöfer, Qingyi, Mandelkow, Eckhard, Meijer, Laurent, ...
Protein kinases of the microtubule affinity-regulating kinase (MARK) family were originally discovered because of their ability to phosphorylate certain sites in tau protein (KXGS motifs in the...
MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1
Timm, Thomas, Li, Xiao-Yu, Biernat, Jacek, Jiao, Jian, Mandelkow, Eckhard, Vandekerckhove, Joel, ...
MARK, a kinase family related to PAR-1 involved in establishing cell polarity, phosphorylates microtubule-associated proteins (tau/MAP2/MAP4) at KXGS motifs, causes detachment from microtubules, and...
PAK5 Kinase Is an Inhibitor of MARK/Par-1, Which Leads to Stable Microtubules and Dynamic ActinD⃞
Matenia, Dorthe, Griesshaber, Bettina, Li, Xiao-yu, Thiessen, Anja, Johne, Cindy, Jiao, Jian, ...
MARK/Par-1 is a kinase involved in development of embryonic polarity. In neurons, MARK phosphorylates tau protein and causes its detachment from microtubules, the tracks of axonal transport. Because...
MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons
Mandelkow, Eva-Maria, Thies, Edda, Trinczek, Bernhard, Biernat, Jacek, Mandelkow, Eckard
Microtubule-dependent transport of vesicles and organelles appears saltatory because particles switch between periods of rest, random Brownian motion, and active transport. The transport can be...
Domains of Neuronal Microtubule-associated Proteins and Flexural Rigidity of Microtubules
Felgner, Harald, Frank, Rainer, Biernat, Jacek, Mandelkow, Eva-Maria, Mandelkow, Eckhard, Ludin, Beat, ...
Microtubules are flexible polymers whose mechanical properties are an important factor in the determination of cell architecture and function. It has been proposed that the two most prominent...
Johne, Cindy, Matenia, Dorthe, Li, Xiao-yu, Timm, Thomas, Balusamy, Kiruthiga, Mandelkow, Eva-Maria
The signaling from MARKK/TAO1 to the MAP/microtubule affinity-regulating kinase MARK/Par1 to phosphorylated microtubule associated proteins (MAPs) renders microtubules dynamic and plays a role in...
Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein
Timm, Thomas, Marx, Alexander, Panneerselvam, Saravanan, Mandelkow, Eckhard, Mandelkow, Eva-Maria
Protein kinases of the MARK family phosphorylate tau protein in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical...
A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation
Paquet, Dominik, Bhat, Ratan, Sydow, Astrid, Mandelkow, Eva-Maria, Berg, Stefan, Hellberg, Sven, ...
Our aging society is confronted with a dramatic increase of patients suffering from tauopathies, which include Alzheimer disease and certain frontotemporal dementias. These disorders are...