MyD88 is required for the formation of long-term humoral immunity to virus infection (2007)
Guay, Heath M., Andreyeva, Tatyana A., Garcea, Robert L., Welsh, Raymond M., Szomolanyi-Tsuda, Eva
Development of long-term humoral immunity is a major goal of vaccination, but the mechanisms involved in the formation of long-term Ab responses are still being determined. In this study, we identify...
Jellison, Evan Robert, Guay, Heath M., Szomolanyi-Tsuda, Eva, Welsh, Raymond M.
Hypergammaglobulinemia and production of autoantibodies occur during many viral infections, and studies have suggested that viral antigen-presenting B cells may become polyclonally activated by CD4 T...
Role for TLR2 in NK cell-mediated control of murine cytomegalovirus in vivo (2006)
Szomolanyi-Tsuda, Eva, Liang, Xueya, Welsh, Raymond M., Kurt-Jones, Evelyn A., Finberg, Robert W.
Natural killer (NK) cells are essential for the early control of murine cytomegalovirus (MCMV) infection. Here, we demonstrate that toll-like receptor 2 (TLR2) plays a role in the NK cell-mediated...
Kemball, Christopher C., Lee, Eun D. Han, Szomolanyi-Tsuda, Eva, Pearson, Thomas A., Larsen, Christian P., Lukacher, Aron E.
The requirement for costimulation in antiviral CD8+ T cell responses has been actively investigated for acutely resolved viral infections, but it is less defined for CD8+ T cell responses to...
Judging a virus by its cover (2004)
Szomolanyi-Tsuda, Eva, Welsh, Raymond M.
The production of protective neutralizing antibodies occurs quickly in some viral infections but very slowly in others. In a new study, surface glycoproteins (the targets of neutralization) of 2...
Mycoplasma infection induces a scleroderma-like centrosome autoantibody response in mice (2004)
Gavanescu, Irina Catrinel, Pihan, German A., Halilovic, Ensar, Szomolanyi-Tsuda, Eva, Welsh, Raymond M., Doxsey, Stephen J.
Development of autoantibodies to intracellular molecules is a universal feature of autoimmune diseases and parallels onset of chronic inflammatory pathology. Initiating antigens of disease-specific...
Alugupalli, Kishore R., Gerstein, Rachel M., Chen, Jianzhu, Szomolanyi-Tsuda, Eva, Woodland, Robert T., Leong, John M.
The rate of pathogen clearance is a critical determinant of morbidity and mortality. We sought to characterize the immune response responsible for the remarkably rapid clearance of individual...
Innate immunity to viruses: control of vaccinia virus infection by gamma delta T cells (2001)
Selin, Liisa K., Santolucito, Paul A., Pinto, Amelia K., Szomolanyi-Tsuda, Eva, Welsh, Raymond M.
The existence of gammadelta T cells has been known for over 15 years, but their significance in innate immunity to virus infections has not been determined. We show here that gammadelta T cells are...
The role of CD40-CD154 interaction in antiviral T cell-independent IgG responses (2000)
Szomolanyi-Tsuda, Eva, Brien, James D., Dorgan, Jill E., Welsh, Raymond M., Garcea, Robert L.
Polyomavirus (PyV) infection elicits protective T cell-independent (TI) IgG responses in T cell-deficient mice. The question addressed in this report is whether CD40 signaling plays a role in this TI...
Szomolanyi-Tsuda, Eva, Le, Quang P., Garcea, Robert L., Welsh, Raymond M.
Immunoglobulin G (IgG) responses to viruses are generally assumed to be T-cell dependent (TD). Recently, however, polyomavirus (PyV) infection of T-cell-deficient (T-cell receptor beta chain...
T cell-independent antibody-mediated clearance of polyoma virus in T cell-deficient mice (1996)
Szomolanyi-Tsuda, Eva, Welsh, Raymond M.
Polyomavirus (PyV) infection of SCID mice, which lack functional T and B cells, leads to a lethal acute myeloproliferative disease (AMD) and to high levels of virus replication in several organs by...
Szomolanyi-Tsuda, Eva, Dundon, Patricia L., Joris, Isabelle, Shultz, Leonard D., Woda, Bruce A., Welsh, R M
Infection of severe combined immunodeficient mice, which lack T and B lymphocytes, with polyomavirus (PyV) induced an acute hematological disorder leading to the death of the mice by 2 weeks...
Medveczky, Maria M., Szomolanyi-Tsuda, Eva, Hesselton, RuthAnn M., DeGrand, David, Geck, Peter, Medveczky, Peter G.
Herpesvirus saimiri is a primate tumor virus that induces acute T-cell lymphomas in New World monkeys. Strains of this virus have been previously classified into three groups on the basis of extreme...
In vitro immortalization of marmoset cells with three subgroups of herpesvirus saimiri (1987)
Szomolanyi-Tsuda, Eva, Medveczky, Peter G., Mulder, Carel
Sequences within the rightmost 7 kilobases of the unique L DNA of herpesvirus saimiri are required for oncogenicity of the virus. The same DNA region has been found to be highly variable among...
Szomolanyi-Tsuda, Eva, Le, Quang P., Garcea, Robert L., Welsh, Raymond M.
Immunoglobulin G (IgG) responses to viruses are generally assumed to be T-cell dependent (TD). Recently, however, polyomavirus (PyV) infection of T-cell-deficient (T-cell receptor β chain [TCR-β]...
Szomolanyi-Tsuda, Eva, Welsh, Raymond M.
The production of protective neutralizing antibodies occurs quickly in some viral infections but very slowly in others. In a new study, surface glycoproteins (the targets of neutralization) of 2...
Role for TLR2 in NK Cell-Mediated Control of Murine Cytomegalovirus In Vivo
Szomolanyi-Tsuda, Eva, Liang, Xueya, Welsh, Raymond M., Kurt-Jones, Evelyn A., Finberg, Robert W.
Natural killer (NK) cells are essential for the early control of murine cytomegalovirus (MCMV) infection. Here, we demonstrate that toll-like receptor 2 (TLR2) plays a role in the NK cell-mediated...
Szomolanyi-Tsuda, Eva, Le, Quang P., Garcea, Robert L., Welsh, Raymond M.
Immunoglobulin G (IgG) responses to viruses are generally assumed to be T-cell dependent (TD). Recently, however, polyomavirus (PyV) infection of T-cell-deficient (T-cell receptor β chain [TCR-β]...
Szomolanyi-Tsuda, Eva, Welsh, Raymond M.
The production of protective neutralizing antibodies occurs quickly in some viral infections but very slowly in others. In a new study, surface glycoproteins (the targets of neutralization) of 2...
Role for TLR2 in NK Cell-Mediated Control of Murine Cytomegalovirus In Vivo
Szomolanyi-Tsuda, Eva, Liang, Xueya, Welsh, Raymond M., Kurt-Jones, Evelyn A., Finberg, Robert W.
Natural killer (NK) cells are essential for the early control of murine cytomegalovirus (MCMV) infection. Here, we demonstrate that toll-like receptor 2 (TLR2) plays a role in the NK cell-mediated...
Kemball, Christopher C., Szomolanyi-Tsuda, Eva, Lukacher, Aron E.
CD4+ T-cell help enables antiviral CD8+ T cells to differentiate into fully competent memory cells and sustains CD8+ T-cell-mediated immunity during persistent virus infection. We recently reported...