Evelyn A. Kurt-Jones

Spontaneous expression of embryonic factors and p53 point mutations in aged mesenchymal stem cells: a model of age-related tumorigenesis in mice (2007)

Li, Hanchen, Fan, Xueli, Kovi, Ramesh C., Jo, YunJu, Moquin, Brian, Konz, Richard, ...

Aging is the single most common risk factor for cancer. Peripheral and marrow-derived stem cells are long lived and are candidate cells for the cancer-initiating cell. Repeated rounds of replication...

Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance (2007)

Thornley, Thomas B., Phillips, Nancy E., Beaudette-Zlatanova, Britte C., Markees, Thomas G., Bahl, Kapil, Brehm, Michael A., ...

TLR activation of innate immunity prevents the induction of transplantation tolerance and shortens skin allograft survival in mice treated with costimulation blockade. The mechanism by which TLR...

Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses (2006)

Kurt-Jones, Evelyn A., Cao, LuCheng, Sandor, Frantisek, Rogers, Arlin B., Whary, Mark T., Nambiar, Prashant R., ...

Trefoil family factor 2 (TFF2), also known as spasmolytic peptide, is a low-molecular-weight protein that is upregulated in gastric tissues infected with Helicobacter or having other inflammatory...

Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4 (2004)

Mandell, Leisa, Moran, Anthony P., Cocchiarella, Andrew, Houghton, JeanMarie, Taylor, Nancy, Fox, James G., ...

Molecular and genetic studies have demonstrated that members of the Toll-like receptor (TLR) family are critical innate immune receptors. TLRs are recognition receptors for a diverse group of...

Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling (2003)

Sandor, Frantisek, Latz, Eicke, Re, Fabio, Mandell, Leisa, Repik, Galina, Golenbock, Douglas, ...

Recognition of ligands by toll-like receptor (TLR) 2 requires interactions with other TLRs. TLRs form a combinatorial repertoire to discriminate between the diverse microbial ligands. Diversity...

Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction (2002)

Latz, Eicke, Visintin, Alberto, Lien, Egil, Fitzgerald, Kate A., Monks, Brian G., Kurt-Jones, Evelyn A., ...

Mammalian responses to LPS require the expression of Toll-like receptor 4 (TLR4), CD14, and MD-2. We expressed fluorescent TLR4 in cell lines and found that TLR4 densely localized to the surface and...

Role of toll-like receptor 2 (TLR2) in neutrophil activation: GM-CSF enhances TLR2 expression and TLR2-mediated interleukin 8 responses in neutrophils (2002)

Kurt-Jones, Evelyn A., Mandell, Leisa, Whitney, Constance, Padgett, Alison, Gosselin, Kerri, Newburger, Peter E., ...

In vitro studies as well as clinical trials indicate that the cytokines granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) enhance the ability...

Involvement of Toll-Like Receptor 4 in Innate Immunity to Respiratory Syncytial Virus

Haynes, Lia M., Moore, Deborah D., Kurt-Jones, Evelyn A., Finberg, Robert W., Anderson, Larry J., Tripp, Ralph A.

The mammalian Toll-like receptor 4, TLR4, is an important component in the innate immune response to gram-negative bacterial infection. The role of TLR4 in antiviral immunity has been largely...

Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2

Compton, Teresa, Kurt-Jones, Evelyn A., Boehme, Karl W., Belko, John, Latz, Eicke, Golenbock, Douglas T., ...

Human cytomegalovirus (CMV) is a ubiquitous opportunistic pathogen that causes significant morbidity and mortality in immuncompromised people. An understanding of how CMV induces and circumvents host...

Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis

Kurt-Jones, Evelyn A., Chan, Melvin, Zhou, Shenghua, Wang, Jennifer, Reed, George, Bronson, Roderick, ...

Human neonates infected with herpes simplex virus 1 (HSV-1) develop one of three distinct patterns of infection: (i) infection limited to the skin, eye or mouth; (ii) infection of the CNS; or (iii)...

Intact Gram-Negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus Bacteria Activate Innate Immunity via Toll-Like Receptor 2 but Not Toll-Like Receptor 4

Mandell, Leisa, Moran, Anthony P., Cocchiarella, Andrew, Houghton, JeanMarie, Taylor, Nancy, Fox, James G., ...

Molecular and genetic studies have demonstrated that members of the Toll-like receptor (TLR) family are critical innate immune receptors. TLRs are recognition receptors for a diverse group of...

Varicella-Zoster Virus Activates Inflammatory Cytokines in Human Monocytes and Macrophages via Toll-Like Receptor 2

Wang, Jennifer P., Kurt-Jones, Evelyn A., Shin, Ok S., Manchak, Michael D., Levin, Myron J., Finberg, Robert W.

The pattern recognition receptor Toll-like receptor 2 (TLR2) has been implicated in the response to several human viruses, including herpes simplex viruses (types 1 and 2) and cytomegalovirus. We...

Role for TLR2 in NK Cell-Mediated Control of Murine Cytomegalovirus In Vivo

Szomolanyi-Tsuda, Eva, Liang, Xueya, Welsh, Raymond M., Kurt-Jones, Evelyn A., Finberg, Robert W.

Natural killer (NK) cells are essential for the early control of murine cytomegalovirus (MCMV) infection. Here, we demonstrate that toll-like receptor 2 (TLR2) plays a role in the NK cell-mediated...

Involvement of Toll-Like Receptor 4 in Innate Immunity to Respiratory Syncytial Virus

Haynes, Lia M., Moore, Deborah D., Kurt-Jones, Evelyn A., Finberg, Robert W., Anderson, Larry J., Tripp, Ralph A.

The mammalian Toll-like receptor 4, TLR4, is an important component in the innate immune response to gram-negative bacterial infection. The role of TLR4 in antiviral immunity has been largely...

Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2

Compton, Teresa, Kurt-Jones, Evelyn A., Boehme, Karl W., Belko, John, Latz, Eicke, Golenbock, Douglas T., ...

Human cytomegalovirus (CMV) is a ubiquitous opportunistic pathogen that causes significant morbidity and mortality in immuncompromised people. An understanding of how CMV induces and circumvents host...

Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis

Kurt-Jones, Evelyn A., Chan, Melvin, Zhou, Shenghua, Wang, Jennifer, Reed, George, Bronson, Roderick, ...

Human neonates infected with herpes simplex virus 1 (HSV-1) develop one of three distinct patterns of infection: (i) infection limited to the skin, eye or mouth; (ii) infection of the CNS; or (iii)...

Intact Gram-Negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus Bacteria Activate Innate Immunity via Toll-Like Receptor 2 but Not Toll-Like Receptor 4

Mandell, Leisa, Moran, Anthony P., Cocchiarella, Andrew, Houghton, JeanMarie, Taylor, Nancy, Fox, James G., ...

Molecular and genetic studies have demonstrated that members of the Toll-like receptor (TLR) family are critical innate immune receptors. TLRs are recognition receptors for a diverse group of...

Varicella-Zoster Virus Activates Inflammatory Cytokines in Human Monocytes and Macrophages via Toll-Like Receptor 2

Wang, Jennifer P., Kurt-Jones, Evelyn A., Shin, Ok S., Manchak, Michael D., Levin, Myron J., Finberg, Robert W.

The pattern recognition receptor Toll-like receptor 2 (TLR2) has been implicated in the response to several human viruses, including herpes simplex viruses (types 1 and 2) and cytomegalovirus. We...

Role for TLR2 in NK Cell-Mediated Control of Murine Cytomegalovirus In Vivo

Szomolanyi-Tsuda, Eva, Liang, Xueya, Welsh, Raymond M., Kurt-Jones, Evelyn A., Finberg, Robert W.

Natural killer (NK) cells are essential for the early control of murine cytomegalovirus (MCMV) infection. Here, we demonstrate that toll-like receptor 2 (TLR2) plays a role in the NK cell-mediated...

Trefoil Family Factor 2 Is Expressed in Murine Gastric and Immune Cells and Controls both Gastrointestinal Inflammation and Systemic Immune Responses▿

Kurt-Jones, Evelyn A., Cao, LuCheng, Sandor, Frantisek, Rogers, Arlin B., Whary, Mark T., Nambiar, Prashant R., ...

Trefoil family factor 2 (TFF2), also known as spasmolytic peptide, is a low-molecular-weight protein that is upregulated in gastric tissues infected with Helicobacter or having other inflammatory...

Importance of extra- and intracellular domains of TLR1 and TLR2 in NFκB signaling

Sandor, Frantisek, Latz, Eicke, Re, Fabio, Mandell, Leisa, Repik, Galina, Golenbock, Douglas T., ...

Recognition of ligands by toll-like receptor (TLR) 2 requires interactions with other TLRs. TLRs form a combinatorial repertoire to discriminate between the diverse microbial ligands. Diversity...