Evgenia Pak

EGFRvIII expression and PTEN loss synergistically induce chromosomal instability and glial tumors (2009)

Li, Li, Dutra, Amalia, Pak, Evgenia, Labrie, Joseph E., Gerstein, Rachel M., Pandolfi, Pier Paolo, ...

Glioblastomas often show activation of epidermal growth factor receptor (EGFR) and loss of PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor, but it is not known if...

Comparative sequence analyses reveal sites of ancestral chromosomal fusions in the Indian muntjac genome (2008)

Tsipouri, Vicky, Schueler, Mary G, Hu, Sufen, Dutra, Amalia, Pak, Evgenia, ...

Abstract Background Indian muntjac ( Muntiacus muntjak vaginalis ) has an extreme mammalian karyotype, with only six and seven chromosomes in the female and male, respectively. Chinese muntjac (...

Advantages of q-PCR as a method of screening for gene targeting in mammalian cells using conventional and whole BAC-based constructs (2008)

Gómez-Rodríguez, Julio, Washington, Valance, Cheng, Jun, Dutra, Amalia, Pak, Evgenia, Liu, Pentao, ...

We evaluate here the use of real-time quantitative PCR (q-PCR) as a method for screening for homologous recombinants generated in mammalian cells from either conventional gene-targeting constructs or...

Acinar Cell Apoptosis in Serpini2-Deficient Mice Models Pancreatic Insufficiency (2005)

Stacie K. Loftus, Jennifer L. Cannons, Arturo Incao, Evgenia Pak, Amy Chen, Patricia M. Zerfas, ...

Pancreatic insufficiency (PI) when left untreated results in a state of malnutrition due to an inability to absorb nutrients. Frequently, PI is diagnosed as part of a larger clinical presentation in...

The Chapel Hill hemophilia A dog colony exhibits a factor VIII gene inversion

Lozier, Jay N., Dutra, Amalia, Pak, Evgenia, Zhou, Nan, Zheng, Zhili, Nichols, Timothy C., ...

In the Chapel Hill colony of factor VIII-deficient dogs, abnormal sequence (ch8, for canine hemophilia 8, GenBank no. AF361485) follows exons 1–22 in the factor VIII transcript in place of exons...

Regulation of Telomere Length and Suppression of Genomic Instability in Human Somatic Cells by Ku86

Myung, Kyungjae, Ghosh, Goutam, Fattah, Farjana J., Li, Gang, Kim, Haeyoung, Dutia, Amalia, ...

Ku86 plays a key role in nonhomologous end joining in organisms as evolutionarily disparate as bacteria and humans. In eukaryotic cells, Ku86 has also been implicated in the regulation of telomere...

Acinar Cell Apoptosis in Serpini2-Deficient Mice Models Pancreatic Insufficiency

Loftus, Stacie K, Cannons, Jennifer L, Incao, Arturo, Pak, Evgenia, Chen, Amy, Zerfas, Patricia M, ...

Pancreatic insufficiency (PI) when left untreated results in a state of malnutrition due to an inability to absorb nutrients. Frequently, PI is diagnosed as part of a larger clinical presentation in...

The Chapel Hill hemophilia A dog colony exhibits a factor VIII gene inversion

Lozier, Jay N., Dutra, Amalia, Pak, Evgenia, Zhou, Nan, Zheng, Zhili, Nichols, Timothy C., ...

In the Chapel Hill colony of factor VIII-deficient dogs, abnormal sequence (ch8, for canine hemophilia 8, GenBank no. AF361485) follows exons 1–22 in the factor VIII transcript in place of exons...

Regulation of Telomere Length and Suppression of Genomic Instability in Human Somatic Cells by Ku86

Myung, Kyungjae, Ghosh, Goutam, Fattah, Farjana J., Li, Gang, Kim, Haeyoung, Dutia, Amalia, ...

Ku86 plays a key role in nonhomologous end joining in organisms as evolutionarily disparate as bacteria and humans. In eukaryotic cells, Ku86 has also been implicated in the regulation of telomere...

Acinar Cell Apoptosis in Serpini2-Deficient Mice Models Pancreatic Insufficiency

Loftus, Stacie K, Cannons, Jennifer L, Incao, Arturo, Pak, Evgenia, Chen, Amy, Zerfas, Patricia M, ...

Pancreatic insufficiency (PI) when left untreated results in a state of malnutrition due to an inability to absorb nutrients. Frequently, PI is diagnosed as part of a larger clinical presentation in...

An Unstable Targeted Allele of the Mouse Mitf Gene With a High Somatic and Germline Reversion Rate

Bismuth, Keren, Skuntz, Susan, Hallsson, Jón H., Pak, Evgenia, Dutra, Amalia S., Steingrímsson, Eiríkur, ...

The mouse Mitf gene encodes a transcription factor that is regulated by serine phosphorylation and is critical for the development of melanin-containing pigment cells. To test the role of...

Advantages of q-PCR as a method of screening for gene targeting in mammalian cells using conventional and whole BAC-based constructs

Gómez-Rodríguez, Julio, Washington, Valance, Cheng, Jun, Dutra, Amalia, Pak, Evgenia, Liu, Pentao, ...

We evaluate here the use of real-time quantitative PCR (q-PCR) as a method for screening for homologous recombinants generated in mammalian cells from either conventional gene-targeting constructs or...

TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans

Washington, A. Valance, Gibot, Sébastien, Acevedo, Ismael, Gattis, James, Quigley, Laura, Feltz, Robert, ...

Triggering receptor expressed on myeloid cells–like (TREM-like) transcript-1 (TLT-1), a type 1 single Ig domain orphan receptor specific to platelet and megakaryocyte α-granules, relocates to the...

Comparative sequence analyses reveal sites of ancestral chromosomal fusions in the Indian muntjac genome

Tsipouri, Vicky, Schueler, Mary G, Hu, Sufen, Dutra, Amalia, Pak, Evgenia, Riethman, Harold, ...

Comparative mapping and sequencing was used to characterize the sites of ancestral chromosomal fusions in the Indian muntjac genome.