Ewald R. Weibel

DESIGN OF THE OXYGEN AND SUBSTRATE PATHWAYS V. STRUCTURAL BASIS OF VASCULAR SUBSTRATE SUPPLY TO MUSCLE CELLS (2008)

Ruth Vock, Ewald R. Weibel, Hans Hoppeler, George Ordway, Jean-michel Weber, C. Richard Taylor

This paper quantifies the structural capacity of the transport steps for oxygen, glucose and fatty acids from the blood in capillaries to the cytosol of muscle cells and compares it with maximal...

Deconvoluting lung evolution: from phenotypes to gene regulatory networks (2007)

Torday, John S., Rehan, Virender K., Hicks, James W., Wang, Tobias, Maina, John, Weibel, Ewald R., ...

Speakers in this symposium presented examples of respiratory regulation that broadly illustrate principles of evolution from whole organ to genes. The swim bladder and lungs of aquatic and...

Counterpoint: Chronic Hypoxia-induced Pulmonary Hypertension does not Lead to Loss of Pulmonary Vasculature (2007)

Ewald R. Weibel, Matthias Ochs, N. Regamey, M. Ochs, ...

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ELECTRON MICROSCOPIC AND MORPHOMETRIC STUDY OF RATS EXPOSED TO 98.5 PERCENT OXYGEN AT ATMOSPHERIC PRESSURE (2006)

Kistler, Gonzague S., Caldwell, Peter R., Weibel, Ewald R.

Rats were exposed to 98.5% oxygen at 765 Torr in a controlled environmental chamber. Groups were sacrificed at 6, 24, 48, and 72 hours and the lungs were prepared for light and electron microscopic...

ELECTRON MICROSCOPIC AND MORPHOMETRIC STUDY OF MONKEY AND DOG LUNGS EXPOSED TO BERYLLIUM-CONTAINING DUST (2006)

Conradi, Carmen R., Kapanci, Yusuf, Weibel, Ewald R., Sopher, Roger L.

Five monkeys and six dogs were exposed three times for 30 minutes each at monthly intervals to an atmosphere contaminated by a beryllium compound whose chief component was beryllium oxide. Two years...

PULMONARY PATHOLOGY OF OXYGEN TOXICITY: PART I. ELECTRON MICROSCOPIC AND MORPHOMETRIC STUDY OF RAT LUNGS EXPOSED TO 98.5% O2 AT ATMOSPHERIC PRESSURE. (2005)

Weibel,Ewald R., Kistler,Gonzague S., Caldwell,Peter R. B.

Rats were exposed to pure oxygen at 1 atm. The lungs were investigated by electron microscopy using morphometric methods. First damage occurred during the second day and progressed. Capillary blood...

ELECTRON MICROSCOPIC AND MORPHOMETRIC STUDY OF RAT LUNGS EXPOSED TO 97% OXYGEN AT 258 TORR (27,000 FEET). (1998)

Kistler,Gonzague S., Caldwell,Peter R. B., Weibel,Ewald R.

A group of young growing rats was exposed to 97% oxygen at 258 torr in a controlled environmental chamber. They were sacrified in groups after 1, 5, and 14 days and their lungs were processed for...

Molecular architecture of the inner membrane of mitochondria from rat liver: Combined biochemical and stereological study (1986)

Klaus Schwerzmann, Rita Eggman, Ewald R. Weibel

Abstract. The molecular structure of mitochondria and their inner membrane has been studied using a combined approach of stereology and biochemistry. The amount of mitochondrial structures (volume,...

Working underground: Respiratory adaptations in the blind mole rat

Widmer, Hans R., Hoppeler, Hans, Nevo, Eviatar, Taylor, C. Richard, Weibel, Ewald R.

Mole rats (Spalax ehrenbergi superspecies) perform the heavy work of digging their subterranean burrows in Israel under highly hypoxic/hypercapnic conditions. Unlike most other mammals, they can...

Working underground: Respiratory adaptations in the blind mole rat

Widmer, Hans R., Hoppeler, Hans, Nevo, Eviatar, Taylor, C. Richard, Weibel, Ewald R.

Mole rats (Spalax ehrenbergi superspecies) perform the heavy work of digging their subterranean burrows in Israel under highly hypoxic/hypercapnic conditions. Unlike most other mammals, they can...

A MORPHOMETRIC STUDY ON THE THICKNESS OF THE PULMONARY AIR-BLOOD BARRIER

Weibel, Ewald R., Knight, Bruce W.

A reliable knowledge of the thickness of the alveolo-capillary "membrane" or air-blood barrier is of physiologic interest since it is intimately related to a quantitative estimation of such...

NEW CYTOPLASMIC COMPONENTS IN ARTERIAL ENDOTHELIA

Weibel, Ewald R., Palade, George E.

A hitherto unknown rod-shaped cytoplasmic component which consists of a bundle of fine tubules, enveloped by a tightly fitted membrane, was regularly found in endothelial cells of small arteries in...

PRACTICAL STEREOLOGICAL METHODS FOR MORPHOMETRIC CYTOLOGY

Weibel, Ewald R., Kistler, Gonzague S., Scherle, Walter F.

Stereological principles provide efficient and reliable tools for the determination of quantitative parameters of tissue structure on sections. Some principles which allow the estimation of...

DEVELOPMENT OF FINE STRUCTURAL DAMAGE TO ALVEOLAR AND CAPILLARY LINING CELLS IN OXYGEN-POISONED RAT LUNGS

Kistler, Gonzague S., Caldwell, Peter R. B., Weibel, Ewald R.

Rats were exposed to 98.5% oxygen at 765 torr for 6–72 hr. The pulmonary changes were investigated by electron microscopy and by morphometric methods. A progressive thickening of the air-blood...

CORRELATED MORPHOMETRIC AND BIOCHEMICAL STUDIES ON THE LIVER CELL : I. Morphometric Model, Stereologic Methods, and Normal Morphometric Data for Rat Liver

Weibel, Ewald R., Stäubli, Willy, Gnägi, Hans Rudolf, Hess, Felix A.

The basic morphological properties of liver cells are defined in the form of a morphometric model to permit integrated quantitative characterization of functionally important parameters. Stereologic...

CORRELATED MORPHOMETRIC AND BIOCHEMICAL STUDIES ON THE LIVER CELL : II. Effects of Phenobarbital on Rat Hepatocytes

Stäubli, Willy, Hess, Robert, Weibel, Ewald R.

The changes occurring in rat hepatocytes during a 5 day period of treatment with phenobarbital were determined by morphometric and biochemical methods, particular attention being paid to the...

A MORPHOMETRIC STUDY OF THE REMOVAL OF PHENOBARBITAL-INDUCED MEMBRANES FROM HEPATOCYTES AFTER CESSATION OF TREATMENT

Bolender, Robert P., Weibel, Ewald R.

It is well known that phenobarbital (PB) treatment produces an increase in the amount of cytoplasmic membranes of hepatocytes, with a parallel enhancement in the activity of drug-metabolizing...