M. Durante, K. George, F. A. Cucinotta
Durante, M., George, K. and Cucinotta, F. A. Chromosomes Lacking Telomeres are Present in the Progeny of Human Lymphocytes Exposed to Heavy Ions. Radiat. Res. 165, 51–58 (2006). High-charge and...
K. George, V. Willingham, F. A. Cucinotta
George, K., Willingham, V. and Cucinotta, F. A. Stability of Chromosome Aberrations in the Blood Lymphocytes of Astronauts Measured after Space Flight by FISH Chromosome Painting. Radiat. Res. 164,...
Immunofluorescence Detection of Clustered γ-H2AX Foci Induced by HZE-Particle Radiation (2005)
N. Desai, E. Davis, P. O'Neill, M. Durante, F. A. Cucinotta, H. Wu
Desai, N., Davis, E., O'Neill, P., Durante, M., Cucinotta, F. A. and Wu, H. Immunofluorescence Detection of Clustered γ-H2AX Foci Induced by HZE-Particle Radiation. Radiat. Res. 164, 518–522...
Cytogenetic Effects of High-Energy Iron Ions: Dependence on Shielding Thickness and Material (2005)
M. Durante, K. George, G. Gialanella, G. Grossi, C. La Tessa, L. Manti, ...
Durante, M., George, K., Gialanella, G., Grossi, G., La Tessa, C., Manti, L., Miller, J., Pugliese, M., Scampoli, P. and Cucinotta, F. A. Cytogenetic Effects of High-Energy Iron Ions: Dependence on...
J. Miller, C. Zeitlin, F. A. Cucinotta, L. Heilbronn, D. Stephens, J. W. Wilson
Miller, J., Zeitlin, C., Cucinotta, F. A., Heilbronn, L., Stephens, D. and Wilson, J. W. Benchmark Studies of the Effectiveness of Structural and Internal Materials as Radiation Shielding for the...
Katz, Robert, Cucinotta, F. A.
The question of the appropriate extrapolation to low dose has long been a subject of controversy. A linear no-threshold model is favored by regulatory bodies as the basis of RBE assignments and...
Deep Space Design Environments For Human (2002)
M. S. Clowdsley, F. A. Cucinotta, R. K. Tripathi, J. E. Nealy, G. De Angelis
Mission scenarios outside the Earth's protective magnetic shield are being studied. Included are high usage assets in the near-Earth environment for casual trips, for research, and for...
Space Radiation Transport Methods Development (2002)
J. W. Wilson, G. D. Qualls, F. A. Cucinotta, J. W. Norbury, J. H. Heinbockel, J. Tweed
Improved spacecraft shield design requires early entry of radiation constraints into the design process to maximize performance and minimize costs. As a result, we have been investigating high-speed...
Karyotypes of Human Lymphocytes Exposed to High-Energy Iron Ions (2002)
M. Durante, K. George, H. Wu, F. A. Cucinotta
Durante, M., George, K., Wu, H. and Cucinotta, F. A. Karyotypes of Human Lymphocytes Exposed to High-Energy Iron Ions. Radiat. Res. 158, 581–590 (2002). Chromosomal aberrations were analyzed using...
Chromosome Aberrations in the Blood Lymphocytes of Astronauts after Space Flight (2001)
K. George, M. Durante, H. Wu, V. Willingham, G. Badhwar, F. A. Cucinotta
George, K., Durante, M., Wu, H., Willingham, V., Badhwar, G. and Cucinotta, F. A. Chromosome Aberrations in the Blood Lymphocytes of Astronauts after Space Flight. Radiat. Res. 156, 731–738 (2001)....
Space Radiation and Cataracts in Astronauts (2001)
F. A. Cucinotta, F. K. Manuel, J. Jones, G. Iszard, J. Murrey, B. Djojonegro, ...
Cucinotta, F. A., Manuel, F. K., Jones, J., Iszard, G., Murrey, J., Djojonegro, B. and Wear, M. Space Radiation and Cataracts in Astronauts. Radiat. Res. 156, 460–466 (2001). For over 30 years,...
A. L. Ponomarev, F. A. Cucinotta, R. K. Sachs, D. J. Brenner, L. E. Peterson
Ponomarev, A. L., Cucinotta, F. A., Sachs, R. K., Brenner, D. J. and Peterson, L. E. Extrapolation of the DNA Fragment-Size Distribution after High-Dose Irradiation to Predict Effects at Low Doses....
Rejoining of Isochromatid Breaks Induced by Heavy Ions in G2-Phase Normal Human Fibroblasts (2001)
T. Kawata, M. Durante, Y. Furusawa, K. George, H. Ito, H. Wu, ...
Kawata, T., Durante, M., Furusawa, Y., George, K., Ito, H., Wu, H. and Cucinotta, F. A. Rejoining of Isochromatid Breaks Induced by Heavy Ions in G2-Phase Normal Human Fibroblasts. Radiat. Res. 156,...
Risk Estimation Based on Chromosomal Aberrations Induced by Radiation (2001)
M. Durante, S. Bonassi, K. George, F. A. Cucinotta
Durante, M., Bonassi, S., George, K. and Cucinotta, F. A. Risk Estimation based on Chromosomal Aberrations Induced by Radiation. Radiat. Res. 156, 662–667 (2001). The presence of a causal...
A detailed spacesuit computational model is being developed at the Langley Research Center for radiation exposure evaluation studies. The details of the construction of the spacesuit are critical to...
G. D. Quails, J. W. Wilson, F. A. Cucinotta, J. E. Nealy, J. H. Heinbockel, ...
The projected radiation levels within the International Space Station (ISS) have been criticized by the Aerospace Safety Advisory Panel in their report to the NASA Administrator. Methods for optimal...
G. D. Qualls, J. W. Wilson, F. A. Cucinotta, W. Atwell, R. Barber
The projected radiation levels within the International Space Station (ISS) have been criticized by the Aerospace Safety Advisory Panel in their report to the NASA Administrator. Methods for optimal...
Importance Of Nuclear Physics To Nasa's Space Missions (2001)
R. K. Tripathi, F. A. Cucinotta
. We show that nuclear physics is extremely important for accurate risk assessments for space missions. Due to paucity of experimental input radiation interaction information it is imperative to...
Deep Space Mission Radiation Shielding Optimization (2001)
R. K. Tripathi, J. W. Wilson, F. A. Cucinotta, J. E. Nealy, M. S. Clowdsley
Providing protection against the hazards of space radiation is a major challenge to the exploration and development of space. The great cost of added radiation shielding is a potential limiting...
Estimation of neutron and other radiation exposure comonents in low earth orbit (2001)
Singleterry, R.C., Badavi, F.F., Shinna, J.L., Cucinotta, F.A., Badhwar, G.D., Clowdsley, M.S., ...
The interaction of high-energy space radiation with spacecraft materials generates a host of secondary particles, some, such as neutrons, are more biologically damaging and penetrating than the...
Shield Materials Optimization and Testing (2000)
J. W. Wilson, F. A. Cucinotta, R. K. Tripathi, M. S. Clowdsley, J. L. Shinn, R. C. Singleterry, ...
Introduction Methods by which radiation shielding is optimized need to be developed and materials of improved shielding characteristics identified and validated. The GCR are very penetrating and the...
Shield Materials Optimization and Testing (2000)
F. A. Cucinotta, R. K. Tripathi, M. S. Clowdsley, J. L. Shinn, R. C. Singleterry, S. A. Thibeault, ...
Introduction Methods by which radiation shielding is optimized need to be developed and materials of improved shielding characteristics identified and validated. The GCR are very penetrating and the...
Optimized Shielding for Space Radiation Protection (2000)
J. W. Wilson, F. A. Cucinotta, W. Schimmerling
. Future deep space mission and International Space Station exposures will be dominated by the high-charge and-energy (HZE) ions of the Galactic Cosmic Rays (GCR). A few mammalian systems have been...
Optimized Shielding for Space Radiation Protection (2000)
J. W. Wilson, F. A. Cucinotta, W. Schimmerling
. Future deep space mission and International Space Station exposures will be dominated by the high-charge and-energy (HZE) ions of the Galactic Cosmic Rays (GCR). A few mammalian systems have been...
Katz, Robert, Cucinotta, F. A., Fromm, M., Chambaudet, A.
Unanticipated late effects in neutron and heavy ion therapy, not attributable to overdose, imply a qualitative difference between low and high LET therapy. We identify that difference as 'ion kill',...
F. A. Cucinotta, H. Nikjoo, D. T. Goodhead
Cucinotta, F. A., Nikjoo, H. and Goodhead, D. T. Model for Radial Dependence of Frequency Distributions for Energy Imparted in Nanometer Volumes from HZE Particles. This paper develops a...
Natural Interplanetary Transfer of Ciable Microbes in Ejecta (2000)
Mileikowsky, C., F.A. Cucinotta, W. Wilson, B. Gladman, G. Horneck, L. Lindgren, ...
Paper Number 1999-01-2173 (1999)
J. W. Wilson, L. C. Simonsen, J. L. Shinn, F. A. Cucinotta, F. F. Badavi, ...
The normal working and living areas of the astronauts are designed to provide an acceptable level of protection against the hazards of ionizing radiation of the space environment. Still there are...
Katz, Robert, Cucinotta, F. A.
Studies of the structure of particle tracks have led to models of track effects based on radial dose and radiobiological target theory that have been very successful in describing and predicting...
NUCFRG2: An Evaluation of the Semiempirical Nuclear Fragmentation Database (1998)
J. W. Wilson, R. K. Tripathi, F. A. Cucinotta, J. L. Shinn, F. F. Badavi, S. Y. Chun, ...
A semiempirical abrasion-ablation model has been successful in generating a large nuclear database for the study of high charge and energy (HZE) ion beams, radiation physics, and galactic cosmic ray...
Cucinotta, F. A., Katz, Robert, Wilson, J. W.
An analytic method is described for evaluating the average radial electron spectrum and the radial and total frequency-event spectrum for high-energy ions. For high-energy ions, indirect events make...
P. M. O'neill, J. L. Shinn, F. A. Cucinotta, J. W. Wilson, G. D. Badhwar, F. F. Badavi
Recent improvements in the radiation transport code HZETRN/BRYNTRN and galactic cosmic ray environmental model have provided an opportunity to investigate the effects of target fragmentation on...
The Local Tissue Environment During The September 29, 1989 Solar Particle Event (1998)
J. W. Wilson, F. A. Cucinotta, L. C. Simonsen, W. Atwell, F. F. Badavi, ...
The solar particle event (SPE) of September 29, 1989, produced an iron-rich spectrum with energies approaching 1 GeV/amu with an energy power index of 2.5. These high charge and energy (HZE) ions of...
Biological Response To Spe Exposures (1998)
J. W. Wilson, F. A. Cucinotta, M. Kim, J. L. Shinn, T. D. Jones, C. K. Chang
It has long been recognized that a single solar particle event (SPE) can produce, over a short period of time, exposures on the order of LD 50 for humans under normal physiological conditions. It is...
J. W. Wilson, F. A. Cucinotta, M. Kim, J. L. Shinn, T. D. Jones, C. K. Chang
It has long been recognized that a single solar particle event (SPE) can produce, over a short period of time, exposures on the order of LD 50 for humans under normal physiological conditions. It is...
Shielding Strategies for Human Space Exploration (1998)
J. W. Wilson, J. Miller, A. Konradi, F. A. Cucinotta
The shield effectiveness of lunar regolith is compared with possible prefabricated shield materials from Earth, including commercially used shield materials in nuclear facilities. Several of the...
TRACK STRUCTURE AND RADIATION TRANSPORT MODEL FOR SPACE RADIOBIOLOGY STUDIES (1996)
Cucinotta, F. A., Wilson, J. W., Katz, Robert, Atwell, W., Badhwar, G. D., Shavers, M. R.
Radiobiology experiments performed in space are deemed necessary for validation of risk-assessment methods. The understanding of space radiobiology experiments must combine knowledge of the space...
P. M. O'neill, J. L. Shinn, F. A. Cucinotta, J. W. Wilson, G. D. Badhwar, F. F. Badavi
Recent improvements in the radiation transport code HZETRN/BRYNTRN and galactic cosmic ray environmental model have provided an opportunity to investigate the effects of target fragmentation on...
RADIOSENSITIVITY PARAMETERS FOR LETHAL MUTAGENESIS IN CAENORHABDITIS ELEGANS (1994)
Cucinotta, F. A., Wilson, J. W., Katz, Robert
For the first time track structure theory has been applied to radiobiological effects in a living organism. Data for lethal mutagenesis in Caenorhabditis elegans, obtained after irradiation with nine...
A Model of Cell Damage in Space Flight (1993)
Katz, Robert, Cucinotta, F. A., Wilson, J. W., Shinn, J. L., Ngo, Duc M.
Cell damage by high LET radiations has been described by a phenomenological model (track theory) for 20 years and more. Molecules of biological significance (dry enzymes and viruses) act as 1 hit...
RBE VS. DOSE FOR LOW DOSES OF HIGH-LET RADIATIONS (1991)
Katz, Robert, Cucinotta, F. A.
(LET) radiations varies with cellular radiosensitivity parameters and the radiation environment. Of special interest is that the RBE varies as the dose of high-LET radiation to the power (1/m - 1)...