Gold, J., Batterham, M.J., Rekers, H., Harms, M.K., Geurts, T.B.P., Helmyr, P.M.E., ...
Objectives Current research is unclear about the most effective pharmacological agents for managing the loss of weight and fat-free mass common in HIV/AIDS. The aim of this study was to compare...
T-cell immune activation in children with vertically transmitted hepatitis C virus infection (2001)
Giovannetti, A., Mazzetta, F., Coviello, R., Casadei, A. M., Mattia, S., Marziali, M., ...
Improvement of CD4, but not CD8, TCR BV repertoire after HAART (2000)
Giovannetti, A., Kuonen, D., Mazzetta, F., Iebba, F., Lusi, E. A., Rosso, P., ...
Tirelli, U., Vaccher, E., Lazzarin, A., Errante, D., Alessi, E., Crosato, I., ...
The Italian Cooperative Group on AIDS & Tumors (GICAT) is collecting data on the epidemiological and clinical features of Kaposi's sarcoma (KS) in Italy, a country where intravenous drug users...
Incluye bibliografía
SIRIANNI, M. C., ROSSI, P., MORONI, M., ROMAGNANI, S., LAZZARIN, A., CARBONARI, M., ...
An epidemiologic survey of the distribution of lymphoadenopathy syndrome in six Italian cities and its correlation with human T-lymphotropic retrovirus III (HTLV-III) is reported. Serum samples of...
Cassone, A, Palma, C, Djeu, J Y, Aiuti, F, Quinti, I
Polymorphonuclear granulocytes (PMN; or neutrophils) from uninfected or human immunodeficiency virus-infected subjects were tested for their ability to inhibit growth of Candida albicans and produce...
Detection and partial characterization of circulating immune complexes in hydatid disease.
D'Amelio, R, Pontesilli, O, Palmisano, L, Pezzella, M, Vullo, V, Delia, S, ...
Thirty sera from eight patients with disseminated or localized hydatid disease have been examined for the presence of circulating immune complexes (CICs) by the conglutinin-binding assay and for...
Cell-mediated immunity in human cytomegalovirus infection.
Fiorilli, M, Sirianni, M C, Iannetti, P, Panà, A, Divizia, M, Aiuti, F
The direct leukocyte migration inhibition test, in response to cytomegalovirus stimulation, was used to study cell-mediated immunity in a group of children with cytomegalovirus infection. The test...
Aiuti, F, Rossi, P, Sirianni, M C, Carbonari, M, Popovic, M, Sarngadharan, M G, ...
A study was performed to assess the prevalence of specific antibodies to human T cell lymphotropic retrovirus (HTLV-III) in patients with lymphadenopathy syndrome, patients with the acquired immune...
Cassone, A, Palma, C, Djeu, J Y, Aiuti, F, Quinti, I
Polymorphonuclear granulocytes (PMN; or neutrophils) from uninfected or human immunodeficiency virus-infected subjects were tested for their ability to inhibit growth of Candida albicans and produce...
Detection and partial characterization of circulating immune complexes in hydatid disease.
D'Amelio, R, Pontesilli, O, Palmisano, L, Pezzella, M, Vullo, V, Delia, S, ...
Thirty sera from eight patients with disseminated or localized hydatid disease have been examined for the presence of circulating immune complexes (CICs) by the conglutinin-binding assay and for...
Cell-mediated immunity in human cytomegalovirus infection.
Fiorilli, M, Sirianni, M C, Iannetti, P, Panà, A, Divizia, M, Aiuti, F
The direct leukocyte migration inhibition test, in response to cytomegalovirus stimulation, was used to study cell-mediated immunity in a group of children with cytomegalovirus infection. The test...
Aiuti, F, Rossi, P, Sirianni, M C, Carbonari, M, Popovic, M, Sarngadharan, M G, ...
A study was performed to assess the prevalence of specific antibodies to human T cell lymphotropic retrovirus (HTLV-III) in patients with lymphadenopathy syndrome, patients with the acquired immune...
Gastric pathology in patients with common variable immunodeficiency
Zullo, A, Romiti, A, Rinaldi, V, Vecchione, A, Tomao, S, Aiuti, F, ...
BACKGROUND/AIMS—Common variable immunodeficiency (CVID) is an immunological disorder characterised by defective antibody production. Patients with CVID have a high risk of gastric cancer. It has...
Giovannetti, A, Aiuti, A, Pizzoli, P M, Pierdominici, M, Agostini, E, Oliva, A, ...
The molecular mechanisms regulating IFN-gamma production have yet to be well characterized. We describe here how treatment of activated cultures of peripheral blood mononuclear cells (PBMC) with the...
HIV-specific lymphoproliferative responses in asymptomatic HIV-infected individuals.
Pontesilli, O, Carlesimo, M, Varani, A R, Ferrara, R, Guerra, E C, Bernardi, M L, ...
In vitro lymphoproliferative responses to HIV-1 recombinant antigens (gp160, p24, and Rev protein) were studied in 83 patients with asymptomatic HIV-1 infection (CDC groups II and III) and...
Paganelli, R, Scala, E, Capobianchi, M R, Fanales-Belasio, E, D'Offizi, G, Fiorilli, M, ...
We measured the in vitro production of interferon-gamma (IFN-gamma) in five cases of hyper-IgE syndrome (HIgE), induced by mitogens, calcium ionophores and phorbol ester. The biosynthesis of...
Quinti, I, Palma, C, Guerra, E C, Gomez, M J, Mezzaroma, I, Aiuti, F, ...
Mucosal candidiasis is one of the first opportunistic diseases in HIV-infected subjects. In order to understand the relationship between this disease and immunodeficiency to chemically defined,...
Pandolfi, F, Semenzato, G, De Rossi, G, Quinti, I, Guglielmi, C, Pezzutto, A, ...
Among 12 cases of chronic T lymphoproliferative disorders we observed, six patients showed an expansion of mononuclear cells with azurophilic granules usually referred to as large granular...
Pandolfi, F, Corte, G, Quinti, I, Fiorilli, M, Frieligsdorf, A, Bargellesi, A, ...
Peripheral blood lymphocytes from 17 patients with common variable hypogammaglobulinaemia (CVH) were tested for reactivity with the 5/9 monoclonal antibody which reacts with about 15% of normal T-PBL...
Impaired production of interleukins in patients with cell-mediated immunodeficiencies.
Paganelli, R, Aiuti, F, Beverley, P C, Levinsky, R J
The poor mitogen response to phytohaemagglutinin (PHA) of lymphocytes from three patients with cell-mediated immunodeficiencies was restored to normal when supernatants containing interleukin 2...
Sirianni, M C, Pucillo, L P, Fiorilli, M, Aiuti, F, Banck, G, Forsgren, A
The mitogenic activity of the formalin-treated bacterial strains Branhamella catarrhalis, Haemophilus influenzae and the Cowan I strain of Staphylococcus aureus was assessed in peripheral blood...
Fiorilli, M, Sirianni, M C, Pandolfi, F, Quinti, I, Tosti, U, Aiuti, F, ...
The case of an 18-month-old child, affected by malnutrition, severe interstitial pneumonia and immunological abnormalities is reported. Since the age of 10 months, the infant suffered from severe...
Circulating immune complexes in normal pregnant women and in some conditions complicating pregnancy.
D'Amelio, R, Bilotta, P, Pachì, A, Aiuti, F
The polyethylene-glycol (PEG) precipitation assay was used to examine the sera of sixty-nine pregnant women, thirty with normal pregnancies, ten with toxaemia of pregnancy, eleven with pregnancy...
Sirianni, M C, Pandolfi, F, Aiuti, F, Wigzell, H
Staphylococcus aureus protein A-positive bacteria have recently been proposed as selective B lymphocyte mitogens. We have studied the lymphocyte response to such mitogens in bacteria in normal...
Effect of thymus factor on human precursor T lymphocytes
Aiuti, F., Schirrmacher, V., Ammirati, P., Fiorilli, M.
A pig thymus factor is shown to transform in vitro human immature lymphoid cells (from cord blood, bone marrow and foetal tissue) into mature T lymphocytes forming spontaneous rosettes with sheep...
Businco, L, Rezza, E, Giunchi, G, Aiuti, F
The case is reported of a 4-year-old girl affected with recurrent infections; anaemia, thrombocytopenia, haemorrhages and hepatosplenomegaly. Immunological investigations revealed a defect in...
Paganelli, R, Capobianchi, M R, Ensoli, B, D'Offizi, G P, Facchini, J, Dianzani, F, ...
We have selected 11 patients with primary immunodeficiency disorders predominantly affecting T lymphocyte function (four with ataxia-telangiectasia (AT), four with common variable immunodeficiency...
Perricone, R, Fontana, L, De Carolis, C, Carini, C, Sirianni, M C, Aiuti, F
The complement system was examined in 16 patients with AIDS-related complex (ARC) (n = 5) and/or lymphoadenopathy syndrome (LAS) (n = 11). Of these patients 62.5% showed an impairment of classical...
Ragona, G, Sirianni, M C, Soddu, S, Vercelli, B, Sebastiani, G, Piccoli, M, ...
Patients affected by AIDS-related complex (ARC) show several immunological abnormalities which may lead to a disregulation of immunosurveillance against viral latent infections. In this paper...
HCV infection in patients with primary defects of immunoglobulin production.
Quinti, I, Pandolfi, F, Paganelli, R, El Salman, D, Giovannetti, A, Rosso, R, ...
We tested for infection with hepatitis C virus (HCV) in 58 patients affected by humoral immunodeficiencies: 43 common variable immunodeficiency (CVI), two hyper IgM syndrome (HIM), two IgG subclass...
Antisera were prepared in rabbits against lymphoid cells from peripheral blood of a patient with Bruton-type agammaglobulinaemia. Such antisera could be shown to display a two plateau level of...
Using rabbit–anti-human T lymphocyte antisera in cytotoxic assays estimates of human T lymphocytes in normal or diseased lymphoid populations have been made. Lymphocytes from normal adult blood...
Aiuti, F., Lacava, V., Garofalo, J. A., D'Amelio, R., D'Asero, C.
Peripheral blood lymphocytes of twenty normal controls and twelve patients with primary immunodeficiencies were examined for surface membrane Ig and receptors for C3 complement (B cell markers) and...
Increased IL-6 gene expression and production in patients with common variable immunodeficiency.
Pandolfi, F, Paganelli, R, Oliva, A, Quinti, I, Polidori, V, Fanales-Belasio, E, ...
We have studied IL-6 gene expression and production by in vitro stimulated peripheral blood mononuclear cells (PBMC) isolated from common variable immunodeficiency (CVI) patients. A strong...
Natural killer cells in intravenous drug abusers with lymphadenopathy syndrome.
Poli, G, Introna, M, Zanaboni, F, Peri, G, Carbonari, M, Aiuti, F, ...
We have investigated 25 intravenous drug abusers with the clinical and laboratory features of lymphadenopathy syndrome (LAS) and 10 AIDS patients for the expression of NK activity. LAS and AIDS...
CD28 costimulation and T lymphocyte proliferative responses in HIV-1 infection
CARLESIMO, M, PONTESILLI, O, VARANI, A R, BERNARDI, M L, MAZZONE, A M, ROSSO, R, ...
To investigate whether defective costimulatory signals could be involved in the loss of T lymphocyte functions during HIV-1 infection, we tested the effect of CD28 costimulation on both T cell...
Pandolfi, F, Alario, C, Girardi, E, Rava', L, Ippolito, G, Kunkl, A, ...
We report on the experience of establishing a national network for a quality control programme in evaluating CD4 cell counts in most Italian centres involved in the care of patients with HIV disease....
Giovannetti, A, Ensoli, F, Mazzetta, F, De Cristofaro, M, Pierdominici, M, Muratori, D S, ...
Expression of chemokine receptors and β-chemokine production by peripheral blood mononuclear cells (PBMC) were determined in HIV-1-infected individuals before and after highly active anti-retroviral...
Pierdominici, M, Marziali, M, Giovannetti, A, Oliva, A, Rosso, R, Marino, B, ...
DiGeorge syndrome (DGS) and velocardiofacial syndrome (VCFS) are associated with chromosome 22q11.2 deletion. Limited information is available on the T cell receptor (TCR) Vβ repertoire. We...
Giovannetti, A, Pierdominici, M, Mazzetta, F, Salemi, S, Marziali, M, Kuonen, D, ...
The immunological correlates of highly active antiretroviral therapy (HAART)-induced suppression of human immunodeficiency virus type 1 (HIV-1) replication have been investigated.
GUAZZI, V, AIUTI, F, MEZZAROMA, I, MAZZETTA, F, ANDOLFI, G, Mortellaro, A, ...
Common variable immunodeficiency (CVID) is a heterogeneous syndrome characterized by repeated infections and hypogammaglobulinaemia. Additionally, T-cell abnormalities including lymphopenia,...
A child with atopic features, raised serum IgE, and recurrent infection treated with levamisole.
Businco, L, Laurenti, F, Rossi, P, Galli, E, Aiuti, F
A 6-year-old girl had a long history of severe eczema, asthma, recurrent otitis media, and staphylococcal infections with disseminated chronic skin abscesses. Immunological studies showed a...