Gouw, A. A., Seewann, A., Vrenken, H., Van Der Flier, W. M., Rozemuller, J. M., Barkhof, F., ...
White matter hyperintensities (WMH) are frequently seen on T2-weighted MRI scans of elderly subjects with and without Alzheimer's disease. WMH are only weakly and inconsistently associated with...
Reduced resting-state brain activity in the "default network" in normal aging (2008)
Damoiseaux, J.S., Beckmann, C.F., Arigita, E.J. Sanz, Barkhof, F., Scheltens, Ph., Stam, C.J., ...
Normal aging is associated with cognitive decline. Functions such as attention, information processing, and working memory are compromised. It has been hypothesized that not only regional changes,...
Polman, C., Kappos, L., Freedman, M., Edan, G., Hartung, H.P., Miller, D.H., ...
Background The BENEFIT study examined interferon beta (IFNB)-1b treatment in patients with clinically isolated syndrome (CIS) and ≥ 2 clinically silent brain MRI lesions. Methods Subgroups of 468...
Swanton, J.K., Rovira, A., Tintore, M., Altmann, D.R., Barkhof, F., Filippi, M., ...
Summary: Background: The 2001 and 2005 McDonald criteria allow MRI evidence for dissemination in space (DIS) and dissemination in time (DIT) to be used to diagnose multiple sclerosis in patients who...
Yousry, T.A., Habil, M., Major, E.O., Ryschkewitsch, C., Fahle, G., Fischer, S., ...
Background: Progressive multifocal leukoencephalopathy (PML) was reported to have developed in three patients treated with natalizumab. We conducted an evaluation to determine whether PML had...
Childhood white matter disorders: Quantitative MR imaging and spectroscopy (2006)
Pouwels, P.J.W., Hart, A.A.M., Serrarens, J., Kremer, H.P.H., ...
Purpose: To prospectively investigate whether quantitative magnetic resonance (MR) parameters, including magnetization transfer ratio (MTR), apparent diffusion coefficient (ADC), fractional...
Barkhof, F, STINISSEN, Piet, MEDAER, Rob, HELLINGS, Niels, VANROOSE, Erwin, RAUS, Jef
Hasselt Univ, Diepenbeek, Belgium. Image Anal Ctr, Amsterdam, Netherlands.
STINISSEN, Piet, MEDAER, Rob, HELLINGS, Niels, Barkhof, F, RAUS, Jef
Hasselt Univ, Biomedisch Onderzoeksinstituut, Diepenbeek, Belgium. Transnatl Univ Limburg, Sch Life Sci, Diepenbeek, Belgium. VU Med Ctr, Image Anal Ctr, Amsterdam, Netherlands.
Veltman , D.J., Ruiter, M.B. De, Lazeron, R.H.C., Barkhof, F., Dyck, R. Van, ...
Background. Dissociation, defined as a disruption in usually integrated mental functions, is found not only in DSM-IV dissociative disorders, but also in post-traumatic stress disorder and eating...
fMRI of working memory in Alzheimer's disease and frontotemporal dementia (2004)
Van Swieten, J, Barkhof, F, Pijnenburg, Y, Goekoop, R, Scheltens, P
Cytokine producing CD8(+) T cells are correlated to MRI features of tissue destruction in MS (2003)
Killestein, J., Eikelenboom, M.J., Izeboud, T., Kalkers, N.F., Ader, H.J., Barkhof, F., ...
The interleukin-1 gene family in multiple sclerosis susceptibility and disease course (2003)
Schrijver, H.M., Zwiers, A., Crusius, J.B.A., Knol, D.L., Kalkers, N.F., ...
Increased working memory performance in high-dissociative subjects (2003)
Veltman, D.J., Ruiter, M.B. De, Lazeron, R.H.C., Barkhof, F., Dyck, R. Van, ...
A new leukodystrophy with brainstem and spinal cord involvement and high lactate (2003)
VAN DER KNAAP, MS, BARKHOF, F, Van Coster, Rudy, KRAGELOH-MANN, I, FEIGENBAUM, A, ...
Presurgical identification of sensorimotor cortex (2003)
Ossenblok, P, Leijten, F, De Munck, J, Huiskamp, GJ, Barkhof, F, Boon, Paul
fMRI of working memory in Alzheimer's disease and frontotemporal dementia (2002)
Barkhof, F, Pijnenburg, Y, Goekoop, R, Scheltens, P, Van Scheltens, P
Seasonal variation in immune measurements and MRI markers of disease activity in MS (2002)
Killestein, J., Rep, M.H.G., Meilof, J.F., Ader, H.J., Uitdehaag, B.M., Barkhof, F., ...
Barkhof, F., Filippi, M., Yousry, T., Miller, D.H., Hahn, D., ...
Recently, the clinical efficacy of interferon ß-1b (IFNß-1b) was demonstrated for secondary progressive (SP) multiple sclerosis in a European multicentre study. We evaluated the effect of IFNß-1b...
PRISMS-4: Long-term efficacy of interferon-beta-1a in relapsing MS (2001)
Francis, G, Hughes, R, King, J, Mitchell, P, Joubert, J, McLeod, J, ...
Background: The PRISMS study demonstrated significant clinical and MRI benefit at 2 years for interferon-beta -1a, 22 and 44 meg thrice weekly (tiw), compared with placebo in relapsing-remitting MS....
PRISMS-4: Long-term efficacy of interferon-beta-1a in relapsing MS (2001)
Francis, G, Hughes, R, King, J, Mitchell, P, Joubert, J, McLeod, J, ...
Background: The PRISMS study demonstrated significant clinical and MRI benefit at 2 years for interferon-beta -1a, 22 and 44 meg thrice weekly (tiw), compared with placebo in relapsing-remitting MS....
Bergers, E., Kamphorst, W., Bot, J., Nicolay, K., Castelijns, J. A., ...
We used high-resolution MRI to study the post-mortem appearance of spinal cord multiple sclerosis in relation to histopathology and low-resolution images. Fifty-nine 3 cm long formalin-fixed spinal...
Bergers, E., Kamphorst, W., Ravid, R., Polman, C. H., Barkhof, F., ...
Macroscopic sampling of multiple sclerosis lesions in the brain tends to find chronic lesions. For a better understanding of the dynamics of the multiple sclerosis disease process, research into new...
Cortico-hippocampal communication by way of parallel parahippocampal-subicular pathways (2000)
Witter, M.P., Naber, P.A., Haaften, T. Van, Machielsen, W.C.M., Barkhof, F., ...
Molyneux, P. D., Kappos, L., Polman, C., Pozzilli, C., Barkhof, F., Filippi, M., ...
The recently completed European trial of interferon beta-1b (IFNβ-1b) in patients with secondary progressive multiple sclerosis (SP multiple sclerosis) has given an opportunity to assess the impact...
Spinal xanthomatosis: a variant of cerebrotendinous xanthomatosis (1999)
Verrips, A., Lycklama A Nijeholt, G.J., Barkhof, F., Wesseling, P., ...
Cortical lesions in multiple sclerosis (1999)
Kidd, D., Barkhof, F., McConnell, R., Algra, P. R., Allen, I. V., Revesz, T.
Although previous studies have shown that the lesions of multiple sclerosis may involve the cerebral cortex, there is little published research on the prevalence and distribution of such lesions....
Spinal xanthomatosis: a variant of cerebrotendinous xanthomatosis (1999)
Verrips, A., Lycklama à Nijeholt, G. J., Barkhof, F., Wesseling, P., ...
We describe seven Dutch patients from six families with a slowly progressive, mainly spinal cord syndrome that remained for many years the sole expression of cerebrotendinous xanthomatosis (CTX). MRI...
Barkhof, F., Elton, M., Lindeboom, J., Tas, M.W., Schmidt, W.F., Kok, A.
In multiple sclerosis (MS), periventricular lesions produce atrophy of the corpus callosum (CC), as evidenced by magnetic resonance imaging (MRI). We investigated whether CC atrophy in...
White matter changes on CT and MRI : an overview of visual rating scales (1998)
SCHELTENS, PH, ERKINJUNTI, T, LEYS, D, WAHLUND, LO, INZITARI, D, DEL SER, T, ...
MR imaging in retinoblastoma (1997)
Barkhof, F, Smeets, M, VanderValk, P, Tan, KEWP, Hoogenraad, F, Peeters, J, ...
We studied the appearance of retinoblastoma on unenhanced and gadolinium-enhanced images and the accuracy of tumour staging with MR imaging. The MR images were obtained in 18 children with...
Barkhof, F, Filippi, M, Miller, DH, Scheltens, P, Campi, A, Polman, CH, ...
Valk, J., Tobi, H., Polman, C.H., Hommes, O.R., Barkhof, F., ...
Quantitative assessment of MRI lesion load in monitoring the evolution of multiple sclerosis (1995)
Filippi, M., Horsfield, M. A., Tofts, P. S., Barkhof, F., Thompson, A. J., Miller, D. H.
In recent years, several segmentation techniques have been developed to quantify brain MRI lesion load in multiple sclerosis and are now being used increasingly for both evaluating the natural...
Miller, D. H., Barkhof, F., Nauta, J. J. P.
There is now widespread agreement that serial brain MRI is useful in monitoring treatments designed to modify the course of multiple sclerosis. It has been less clear whether gadolinium enhancement...
SCHELTENS, PH., BARKHOF, F., VALK, J., ALGRA, P. R., NAUTA, J., ...
In a prospective magnetic resonance imaging (MRI) study we evaluted the prevalence and severity of white matter changes in 29 patients with Alzheimer's Disease (AD) and 24 age-matched healthy...
Characterization of tissue damage in multiple sclerosis by nuclear magnetic resonance.
Nuclear magnetic resonance (NMR) imaging is an established diagnostic medium to diagnose multiple sclerosis (MS). In clinically stable MS patients, NMR detects silent disease activity, which is the...
Consistent resting-state networks across healthy subjects
Damoiseaux, J. S., Barkhof, F., Scheltens, P., Stam, C. J., Smith, S. M., ...
Functional MRI (fMRI) can be applied to study the functional connectivity of the human brain. It has been suggested that fluctuations in the blood oxygenation level-dependent (BOLD) signal during...
Miller, D H, Barkhof, F, Berry, I, Kappos, L, Scotti, G, Thompson, A J
Serial gadolinium enhanced MRI of the brain detects much clinically silent disease activity in early relapsing-remitting and secondary progressive multiple sclerosis (MS), and thus has an important...
Scheltens, P, Leys, D, Barkhof, F, Huglo, D, Weinstein, H C, Vermersch, P, ...
Magnetic resonance imaging (MRI) has shown a great reduction in medial temporal lobe and hippocampal volume of patients with Alzheimer's disease as compared to controls. Quantitative volumetric...
MATTERS ARISING: Miller et al reply:
Miller, DH, Barkhof, F, Berry, I, Kappos, L, Scotti, G, Thompson, AJ
Sormani, M, Molyneux, P, Gasperini, C, Barkhof, F, Yousry, T, Miller, D, ...
OBJECTIVES—To evaluate the durations of the follow up and the reference population sizes needed to achieve optimal and stable statistical powers for two period cross over and parallel group design...
One year follow up study of primary and transitional progressive multiple sclerosis
Stevenson, V, Miller, D, Leary, S, Rovaris, M, Barkhof, F, Brochet, B, ...
OBJECTIVE—To document clinical and magnetic resonance imaging (MRI) characteristics of a large cohort of primary and transitional progressive multiple sclerosis (PP and TP MS) patients over one...
Sormani, M, Miller, D, Comi, G, Barkhof, F, Rovaris, M, Bruzzi, P, ...
OBJECTIVE—A new parametric simulation procedure based on the negative binomial (NB) model was used to evaluate the sample sizes needed to achieve optimal statistical powers for parallel groups...
Alzheimer's disease—one clinical syndrome, two radiological expressions: a study on blood pressure
De Leeuw, F-E, Barkhof, F, Scheltens, P
Background: Vascular risk factors could play a role in the aetiology of Alzheimer's disease, but this has not been investigated in relation to neuroimaging findings
Rombouts, S, Barkhof, F, Van Meel, C S, Scheltens, P
Background: Rivastigmine enhances cholinergic activity and has been shown in clinical trials to decrease the rate of deterioration in Alzheimer's disease. It remains unclear where in the brain it...
Tubridy, N, Ader, H, Barkhof, F, Thompson, A, Miller, D
OBJECTIVES—Serial brain MRI is widely used in pilot studies of new agents to monitor treatment efficacy in relapsing-remitting (RR) and secondary progressive (SP) multiple sclerosis (MS). For pilot...
Progression of cerebral white matter lesions in Alzheimer's disease: a new window for therapy?
De Leeuw, F-E, Barkhof, F, Scheltens, P
Objective: To investigate the prevalence and risk factors for progression of WML in Alzheimer's disease.
Van Der Flier, W M, Barkhof, F, Ferro, J, Pantoni, L, Basile, A, ...
Objective: To assess the associations of medial temporal lobe atrophy (MTA) and white matter hyperintensities (WMH) with cognitive function in a large group of independently functioning elderly...
Pijnenburg, Y A L, Schoonenboom, S N M, Barkhof, F, Knol, D L, Mulder, C, Van Kamp, G J, ...
In order to better understand the large variation in cerebrospinal fluid (CSF) tau and amyloid‐beta(1–42) (Aβ42) in frontotemporal lobar degeneration (FTLD), relations between these biomarkers...
Is the whole brain periventricular?
The term periventricular is becoming meaningless and should be abandoned
Increased cortical atrophy in patients with Alzheimer's disease and type 2 diabetes mellitus
Biessels, G J, De Leeuw, F‐E, Lindeboom, J, Barkhof, F, Scheltens, P
Hippocampal atrophy on MRI in frontotemporal lobar degeneration and Alzheimer's disease
Van De Pol, L A, Hensel, A, Van Der Flier, W M, Visser, P‐J, Pijnenburg, Y A L, Barkhof, F, ...
Korteweg, T., Tintore, M., Uitdehaag, B. M. J., Knol, D. L., Vrenken, H., Rovira, A., ...
The International Panel on the Diagnosis of Multiple Sclerosis (MS) incorporated the Barkhof/Tintoré (B/T) magnetic resonance criteria into their diagnostic scheme to provide evidence of...