Human cartilage glycoprotein-39 directed T-cell responses in health and arthritic diseases (2003)
Toes, R, Bilsen, J Van, Lard, L, Miltenburg, A, Breedveld, F, Huizinga, T, ...
No abstract available.
Epidemiology of inclusion body myositis in the Netherlands: a nationwide study (2000)
Badrising, U.A., Maat-Schieman, M., Duinen, S.G. Van, Breedveld, F., Doorn, P. Van, Engelen, B. Van, ...
Synovial biopsy in arthritis research: five years of concerted European collaboration (2000)
Bresnihan, B., Tak, P.P., Emery, P., Klareskog, L., Breedveld, F.
Brooks, P., Emery, P., Evans, J. F., Fenner, H., Hawkey, C. J., Patrono, C., ...
The International Consensus Meeting on the Mode of Action of COX-2 Inhibition (ICMMAC) brought together 17 international experts in arthritis, gastroenterology and pharmacology on 5–6 December...
Ten, W, Hermans, J., Breedveld, F., Dijkmans, B.
OBJECTIVE—To assess the effect of resumption of second line drugs in patients with rheumatoid arthritis (RA) that flared after treatment discontinuation. METHODS—RA patients were studied whose...
Influence of non-inherited maternal HLA-DR antigens on susceptibility to rheumatoid arthritis
Hazes, J, Schreuder, G, Radstake, T, Barrera, P, ...
OBJECTIVE—It has recently been observed that non-inherited maternal DR4 antigens (NIMAs) of DR4 negative rheumatoid arthritis (RA) patients were increased compared with non-inherited paternal DR4...
Voskuyl, A., Van Duinen, S. G, Zwinderman, A., Breedveld, F., Hazes, J.
OBJECTIVE—To determine the diagnostic value of perivascular infiltrates (PVI) in randomly obtained muscle biopsy specimens for the assessment of rheumatoid vasculitis (RV). METHODS—The number...
Van Schendel, P W, Breedveld, F, Schreuder, G, ...
OBJECTIVE—To assess the relation between the course of rheumatoid arthritis (RA) during pregnancy or the onset of RA postpartum and DRB1, DQA1, and DQB1 incompatibilities between mother and...
Meulenbelt, I, Bijkerk, C, Miedema, H, Breedveld, F, Hofman, A, Valkenburg, H, ...
OBJECTIVE—A genetic association study was performed to investigate whether radiographical osteoarthritis (ROA) was associated with specific genotypes of the insulin-like growth factor I (IGF-1)...
Rood, M, Keijsers, V, Van Der Linden, M W, Tong, T, Borggreve, S, Verweij, C, ...
OBJECTIVE—To investigate the association of interleukin 10 (IL10) promoter polymorphisms and neuropsychiatric manifestations of systemic lupus erythematosus (SLE). METHODS—IL10 haplotypes of...
Leflunomide: mode of action in the treatment of rheumatoid arthritis
Leflunomide is a selective inhibitor of de novo pyrimidine synthesis. In phase II and III clinical trials of active rheumatoid arthritis, leflunomide was shown to improve primary and secondary...
Synovial biopsy in arthritis research: five years of concerted European collaboration
Bresnihan, B., Tak, P. P., Emery, P., Klareskog, L., Breedveld, F.
Vos, K, Steenbakkers, P, Miltenburg, A, Bos, E, Van Den Heuvel, M W, Van Hogezand, R A, ...
OBJECTIVE—To evaluate plasma human cartilage glycoprotein (HC gp-39) as a possible marker for the presence and/or activity of rheumatoid arthritis (RA) and other inflammatory...
Verschueren, P., Voskuyl, A., Smeets, T, Zwinderman, K., Breedveld, F., Tak, P.
OBJECTIVE—Histological analysis of random quadriceps muscle biopsy specimens can be used to detect vasculitis in patients with rheumatoid arthritis (RA). This study aimed at determining the...
Breedveld, F, Le Cessie, S, Dijkmans, B, De Mug, A W, Hazes, J
OBJECTIVE—To investigate the effects of a dynamic, intensive exercise regimen on pain, disease activity, and physical functioning in active rheumatoid arthritis (RA). METHODS—64 patients with...
Kraan, M, Smith, M, Weedon, H, Ahern, M, Breedveld, F, Tak, P
OBJECTIVE—Digital image analysis (DIA) offers the opportunity to quantify the stained area and staining intensity when synovial tissue (ST) is investigated by immunohistochemical analysis. This...
CNS involvement in systemic lupus erythematosus: a case with remarkable histopathological findings
Rood, M, Haverman, J, Van Duinen, S G, Breedveld, F, Verschuuren, J, Huizinga, T
Binks, M, Passweg, J, Furst, D, McSweeney, P, Sullivan, K, Besenthal, C, ...
BACKGROUND—Systemic sclerosis (SSc, scleroderma) in either its diffuse or limited skin forms has a high mortality when vital organs are affected. No treatment has been shown to influence the...
Tolboom, T, Pieterman, E, Van Der Laan, W H, Toes, R, Huidekoper, A, Nelissen, R, ...
Background: Matrix metalloproteinases (MMPs) have a pivotal role in the destruction of cartilage in rheumatoid arthritis (RA), which is mediated by the fibroblast-like synoviocytes (FLS).
Emery, P, Breedveld, F, Dougados, M, Kalden, J, Schiff, M, Smolen, J
Objective: To develop a referral recommendation that may serve as a clinical guide for primary care doctors, enabling them to identify patients with suspected RA during the early inflammatory stages.
Drossaers-Bakker, K, Zwinderman, A, Van Zeben, D, Breedveld, F, Hazes, J
Background: Oral contraceptives (OC) and pregnancy are known to have an influence on the risk of onset of rheumatoid arthritis (RA). Pregnancy itself has beneficial effects on the activity of the...
Sarcoid arthritis: clinical characteristics, diagnostic aspects, and risk factors
Visser, H, Vos, K, Zanelli, E, Verduyn, W, Schreuder, G, Speyer, I, ...
Objectives: (a) To describe the clinical characteristics of acute sarcoid arthritis and the diagnostic value of its presenting clinical features; (b) to evaluate whether disease onset is seasonal;...
Hoeksma, H, Ronday, H, Heering, A, Breedveld, F, Dekker, J
Objective: To compare responsiveness of the Harris Hip Score with generic measures (that is, the Short Form-36 (SF-36), and a test of walking speed and pain during walking) in patients with...
Tchetverikov, I, Lard, L, DeGroot, J, Verzijl, N, TeKoppele, J, Breedveld, F, ...
Objective: To analyse the relation between systemic levels of pro-MMP-3, -8, and -9 matrix metalloproteinase (MMP) activity in α2 macroglobulin (α2M)/MMP complexes and the progression of joint...
Rau, R, Breedveld, F, Kalden, J, Malaise, M, ...
Objectives: To evaluate efficacy, dose response, safety, and tolerability of adalimumab (D2E7) in disease modifying antirheumatic drug (DMARD) refractory patients with longstanding, active rheumatoid...
Van Den Hout, W B, Tijhuis, G, Hazes, J, Breedveld, F, Vliet, V
Objective: To assess the relative cost effectiveness of clinical nurse specialist care, inpatient team care, and day patient team care.
Diagnostic strategy for the assessment of rheumatoid vasculitis
Voskuyl, A, Hazes, J, Zwinderman, A, Paleolog, E, Daha, M, ...
Objective: To determine the clinical features associated with histologically proven rheumatoid vasculitis (HRV) and the additional diagnostic value of serological markers in an inception cohort of 81...
Smeets, T, Barg, E, Kraan, M, Smith, M, Breedveld, F, Tak, P
Background: Synovial tissue (ST) from end stage destructive rheumatoid arthritis (RA) and arthroscopic biopsies obtained during active inflammation might exhibit different characteristics.
Infliximab in active early rheumatoid arthritis
Breedveld, F, Emery, P, Keystone, E, Patel, K, Furst, D, Kalden, J, ...
Objective: To examine the impact of the combination of infliximab plus methotrexate (MTX) on the progression of structural damage in patients with early rheumatoid arthritis (RA).
Access to disease modifying treatments for rheumatoid arthritis patients
FURST, D, BREEDVELD, F, BURMESTER, G, CROFFORD, L, EMERY, P, FELDMAN, M, ...
FURST, D, KEYSTONE, E, BREEDVELD, F, KALDEN, J, SMOLEN, J, ANTONI, C, ...
Furst, D, Breedveld, F, Kalden, J, Smolen, J, Antoni, C, Bijlsma, J, ...
Van Aken, J, Lard, L, Le Cessie, S, Hazes, J, Breedveld, F, Huizinga, T
Objective: To determine the effect of different treatment strategies (early versus delayed) on the radiological progression of joint damage during 4 years. Additionally, to determine the effect of...
Kraan, M, Haringman, J, Weedon, H, Barg, E, Smith, M, Ahern, M, ...
Objective: To determine immunohistological markers in synovial tissue of patients with early rheumatoid arthritis (RA) which are associated with unfavourable disease outcome.
Farge, D, Passweg, J, Van Laar, J M, Marjanovic, Z, Besenthal, C, Finke, J, ...
Objective: To analyse the durability of the responses after haematopoietic stem cell transplantation (HSCT) for severe systemic sclerosis (SSc) and determine whether the high transplant related...
Differential effects of leflunomide and methotrexate on cytokine production in rheumatoid arthritis
Kraan, M, Smeets, T, Van Loon, M J, Breedveld, F, Dijkmans, B, Tak, P
Background: T cells have a pivotal role in RA. Leflunomide inhibits pyrimidine biosynthesis, to which T cells are especially susceptible, and therefore may have a different cytokine profile than...
Long term high intensity exercise and damage of small joints in rheumatoid arthritis
De Jong, Z, Munneke, M, Zwinderman, A, Kroon, H, Ronday, K, Lems, W, ...
Objective: To investigate the effect of long term high intensity weightbearing exercises on radiological damage of the joints of the hands and feet in patients with rheumatoid arthritis (RA).
Furst, D, Breedveld, F, Kalden, J, Smolen, J, Burmester, G, Bijlsma, J, ...
Breedveld, F, Han, C, Bala, M, Baker, D, Kavanaugh, A, ...
Objectives: To identify factors associated with poor physical function in rheumatoid arthritis and to assess whether baseline joint damage has an impact on improvement in physical function during...
Riyazi, N, Meulenbelt, I, Kroon, H, Ronday, K, L Hellio,, Rosendaal, F, ...
Objective: To evaluate whether familial aggregation of osteoarthritis differs by joint site in a sibling pair study (GARP) of patients with osteoarthritis at multiple sites.