Unraveling DNA tori under tension (2009)
Battle, C., Broek, B. Van Den, Noom, M. C., Van Mameren, J., Wuite, G. J. L., MacKintosh, F. C.
Motivated by recent experiments, we develop a model for DNA toroids under external tension. We find that tori are the equilibrium states for our model up to a critical tension, above which they...
Co-promotor: Dr. P. R. ten Wolde (2008)
Marco Morelli, Academisch Proefschrift, Marco Morelli, Promotor Prof, Dr. D. Frenkel, Wiskunde En Informatica, ...
ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. D. C. van den Boom ten overstaan van een door het college voor promoties...
Effective medium approach for stiff polymer networks with flexible cross-links (2008)
Broedersz, C. P., Storm, C., MacKintosh, F. C.
Recent experiments have demonstrated that the nonlinear elasticity of in vitro networks of the biopolymer actin is dramatically altered in the presence of a flexible cross-linker such as the abundant...
Crosslinked networks of stiff filaments exhibit negative normal stress (2008)
Conti, Enrico, MacKintosh, F. C.
Motivated by recent experiments showing that stiff biopolymer gels exhibit highly unusual negative normal elastic stresses, we develop a computational model for stiff polymer networks subject to...
Effective temperatures from the fluctuation-dissipation measurements in soft glassy materials (2008)
Jabbari-Farouji, S., Mizuno, D., Derks, D., Wegdam, G. H., MacKintosh, F. C., Schmidt, C. F., ...
We have investigated the validity of the fluctuation-dissipation theorem (FDT) and the applicability of the concept of effective temperature in a number of non-equilibrium soft glassy materials....
Atakhorrami, M., Mizuno, D., Koenderink, G. H., Liverpool, T. B., MacKintosh, F. C., Schmidt, C. F.
We have directly observed short-time stress propagation in viscoelastic fluids using two optically trapped particles and a fast interferometric particle-tracking technique. We have done this both by...
Round versus flat: bone cell morphology, elasticity, and mechanosensing (2008)
Bacabac, R.G., Mizuno, D., Schmidt, C.F., MacKintosh, F.C., Klein Nulend, J., ...
There is increasing evidence that cell function and mechanical properties are closely related to morphology. However, most in vitro studies investigate flat adherent cells, which might not reflect...
Internal structures in membranes: ripples, hats, saddles, and egg cartons (2007)
Membranes such as bilayers that form spontaneously in lipid-water systems can show surprising variety in their phase behavior, shapes, and textures. Many of these phases and textures seem to be the...
High-bandwidth viscoelastic properties of aging colloidal glasses and gels (2007)
Jabbari-Farouji, S., Atakhorram, M., Mizuno, D., Eiser, E., Wegdam, G. H., MacKintosh, F. C., ...
We report measurements of the frequency-dependent shear moduli of aging colloidal systems that evolve from a purely low-viscosity liquid to a predominantly elastic glass or gel. Using microrheology,...
Nonlinear elasticity of composite networks of stiff biopolymers with flexible linkers (2007)
Broedersz, C. P., Storm, C., MacKintosh, F. C.
Motivated by recent experiments showing nonlinear elasticity of in vitro networks of the biopolymer actin cross-linked with filamin, we present an effective medium theory of flexibly cross-linked...
Non-equilibrium microtubule fluctuations in a model cytoskeleton (2007)
Brangwynne, C. P., Koenderink, G. H., MacKintosh, F. C., Weitz, D. A.
Biological activity gives rise to non-equilibrium fluctuations in the cytoplasm of cells; however, there are few methods to directly measure these fluctuations. Using a reconstituted actin...
Buckling and force propagation along intracellular microtubules (2007)
Das, Moumita, Levine, Alex J., MacKintosh, F. C.
Motivated by recent experiments showing the buckling of microtubules in cells, we study theoretically the mechanical response of, and force propagation along elastic filaments embedded in a...
Liu, J., Koenderink, G. H., Kasza, K. E., MacKintosh, F. C., Weitz, D. A.
We image semi-flexible polymer networks under shear at the micrometer scale. By tracking embedded probe particles, we determine the local strain field, and directly measure its uniformity, or degree...
Round versus flat: bone cell morphology, elasticity, and mechanosensing (2007)
Bacabac, R.G., Mizuno, D., Vatsa, A.V., Schmidt, C.F., MacKintosh, F.C., ...
Fluctuation-Dissipation Theorem in an Aging Colloidal Glass (2007)
Jabbari Farouji, S., Mizuno, D., Atakhorrami, M., MacKintosh, F.C., Schmidt, C.F., Eiser, E., ...
Fluctuation-Dissipation Theorem in an Aging Colloidal Glass (2007)
Jabbari Farouji, S., Mizuno, D., Atakhorrami, M., MacKintosh, F.C., Schmidt, C.F., Eiser, E., ...
Fluctuation-dissipation theorem in an aging colloidal glass (2007)
Jabbari Farouji, S., Mizuno, D., Atakhorrami, M., MacKintosh, F.C., Schmidt, C.F., Eiser, E., ...
Effective medium theory of semiflexible filamentous networks (2006)
Das, Moumita, MacKintosh, F. C., Levine, Alex
We develop an effective medium approach to the mechanics of disordered, semiflexible polymer networks and study the response of such networks to uniform and nonuniform strain. We identify distinct...
Microrheology of mechanosensitive bone cells (2006)
Bacabac, R.G., Mizuno, D., Schmidt, C.F., MacKintosh, F.C., Smit, T.H., ...
The mechanical response of semiflexible networks to localized perturbations (2005)
Head, D. A., Levine, A. J., MacKintosh, F. C.
Previous research on semiflexible polymers including cytoskeletal networks in cells has suggested the existence of distinct regimes of elastic response, in which the strain field is either uniform...
Collapse of a semiflexible polymer in poor solvent (2003)
Montesi, Alberto, Pasquali, Matteo, MacKintosh, F. C.
We investigate the dynamics and the pathways of the collapse of a single, semiflexible polymer in a poor solvent via 3-D Brownian Dynamics simulations. Earlier work indicates that the condensation of...
Head, D. A., Levine, A. J., MacKintosh, F. C.
Semiflexible polymers such as filamentous actin play a vital role in the mechanical behavior of cells, yet the basic properties of cross-linked F-actin networks remain poorly understood. To address...
Velocity distributions in dissipative granular gases (2003)
Van Zon, J. S., MacKintosh, F. C.
Motivated by recent experiments reporting non-Gaussian velocity distributions in driven dilute granular materials, we study by numerical simulation the properties of 2D inelastic gases. We find...
Dynamics of rigid and flexible extended bodies in viscous films and membranes (2003)
Levine, Alex J., Liverpool, T. B., MacKintosh, F. C.
We study the dynamics of extended rod-like bodies in (or associated with) membranes and films. We demonstrate a striking difference between the mobilities in films and bulk fluids, even when the...
Non-universality of elastic exponents in random bond-bending networks (2003)
Head, D. A., MacKintosh, F. C., Levine, A. J.
We numerically investigate the rigidity percolation transition in two-dimensional flexible, random rod networks with freely rotating cross-links. Near the transition, networks are dominated by...
Deformation of crosslinked semiflexible polymer networks (2003)
Head, D. A., Levine, A. J., MacKintosh, F. C.
Networks of filamentous proteins play a crucial role in cell mechanics. These cytoskeletal networks, together with various crosslinking and other associated proteins largely determine the...
On the mobility of extended bodies in viscous films and membranes (2003)
Levine, Alex J., Liverpool, T. B., MacKintosh, F. C.
We develop general methods to calculate the mobilities of extended bodies in (or associated with) membranes and films. We demonstrate a striking difference between in-plane motion of rod-like...
Velocity distributions in dilute granular systems (2002)
Van Zon, J. S., MacKintosh, F. C.
Motivated by recent experiments reporting non-Gaussian velocity distributions in driven dilute granular materials, we study by numerical simulation the properties of inelastic gases as functions of...
Metastable Intermediates in the Condensation of Semiflexible Polymers (2001)
Schnurr, B., Gittes, F., MacKintosh, F. C.
Motivated by results from an earlier Brownian Dynamics (BD) simulation for the collapse of a single, stiff polymer in a poor solvent [B. Schnurr, F. C. MacKintosh, and D. R. M. Williams, Europhys....
Dynamics of viscoelastic membranes (2001)
Levine, Alex J., MacKintosh, F. C.
We determine both the in-plane and out-of-plane dynamics of viscoelastic membranes separating two viscous fluids in order to understand microrheological studies of such membranes. We demonstrate the...
Instability of Myelin Tubes under Dehydration: deswelling of layered cylindrical structures (2001)
Schmidt, C. F., Olmsted, P. D., MacKintosh, F. C.
We report experimental observations of an undulational instability of myelin figures. Motivated by this, we examine theoretically the deformation and possible instability of concentric, cylindrical,...
Viscoelastic properties of actin-coated membranes (2001)
Helfer, E., Harlepp, S., Bourdieu, L., Robert, J., MacKintosh, F.C., Chateney, D.
Buckling of actin-coated membranes under application of a local force (2001)
Helfer, E., Harlepp, S., Bourdieu, L., Robert, J., MacKintosh, F.C., Chateney, D.
Buckling of Actin-Coated Membranes under Application of a Local Force (2001)
Bourdieu, L., Harlepp, S., Helfer, E., MacKintosh, F. C., Robert, J.
Theory of Cylindrical Tubules and Helical Ribbons of Chiral Lipid Membranes (1998)
Selinger, J.V., MacKintosh, F.C., Schnur, J.M.
We present a general theory for the equilibrium structure of cylindrical tubules and helical ribbons of chiral lipid membranes. This theory is based on a continuum elastic free energy that permits...
Gittes, F., Schnurr, B., Olmsted, P. D., MacKintosh, F. C., Schmidt, C. F.
We describe a high-resolution, high-bandwidth technique for determining the local viscoelasticity of soft materials such as polymer gels. Loss and storage shear moduli are determined from the power...
Schnurr, B., Gittes, F., MacKintosh, F. C., Schmidt, C. F.
We have developed a new technique to measure viscoelasticity in soft materials such as polymer solutions, by monitoring thermal fluctuations of embedded probe particles using laser interferometry in...
B. Schnurr, F. Gittes, F. C. Mackintosh, C. F. Schmidt
ABSTRACT: We have developed a new technique to measure viscoelasticity in soft materials such as entangled polymer solutions, by monitoring thermal fluctuations of embedded probe particles using...
Instability and front propagation in laser-tweezed lipid bilayer tubules (1996)
Olmsted, Peter D., MacKintosh, F. C.
We study the mechanism of the `pearling' instability seen recently in experiments on lipid tubules under a local applied laser intensity. We argue that the correct boundary conditions are fixed...
n-atic Order and Continuous Shape Changes of Deformable Surfaces of Genus Zero (1996)
Park, Jeong-Man, Lubensky, T. C., MacKintosh, F. C.
We consider in mean-field theory the continuous development below a second-order phase transition of $n$-atic tangent plane order on a deformable surface of genus zero with order parameter $\psi =...
Theory of Cylindrical Tubules and Helical Ribbons of Chiral Lipid Membranes (1995)
Selinger, J. V., MacKintosh, F. C., Schnur, J. M.
We present a general theory for the equilibrium structure of cylindrical tubules and helical ribbons of chiral lipid membranes. This theory is based on a continuum elastic free energy that permits...
Elasticity of Semiflexible Biopolymer Networks (1995)
MacKintosh, F. C., Kas, J., Janmey, P. A.
We develop a model for gels and entangled solutions of semiflexible biopolymers such as F-actin. Such networks play a crucial structural role in the cytoskeleton of cells. We show that the rheologic...
Swelling Kinetics of Layered Structures: Triblock Copolymer Mesogels (1995)
MacKintosh, F. C., Williams, D. R. M.
We consider the swelling kinetics of layered structures. We focus on the case of triblock copolymer mesogels, although our results are applicable to other layered structures including clays. We...
Growth of charged micelles (1990)
Safran, S.A., Pincus, P.A., Cates, M. E., Mackintosh, F.C.
We consider the electrostatics of charged, cylindrical micelles with spherical end-caps. In the semidilute regime (volume fraction Φ 0 depends on the renormalized coulomb charge of an end cap....
Growth of charged micelles (1990)
Safran, S.A., Pincus, P.A., Cates, M. E., Mackintosh, F.C.
We consider the electrostatics of charged, cylindrical micelles with spherical end-caps. In the semidilute regime (volume fraction Φ 0 depends on the renormalized coulomb charge of an end cap....
Growth of charged micelles (1990)
Safran, S.A., Pincus, P.A., Cates, M. E., Mackintosh, F.C.
We consider the electrostatics of charged, cylindrical micelles with spherical end-caps. In the semidilute regime (volume fraction Φ 0 depends on the renormalized coulomb charge of an end cap....
Bacteriophage capsids: Tough nanoshells with complex elastic properties
Ivanovska, I. L., De Pablo, P. J., Ibarra, B., Sgalari, G., MacKintosh, F. C., Carrascosa, J. L., ...
The shell of bacteriophages protects the viral DNA during host-to-host transfer and serves as a high-pressure container storing energy for DNA injection into a host bacterium. Here, we probe the...
Bacteriophage capsids: Tough nanoshells with complex elastic properties
Ivanovska, I. L., De Pablo, P. J., Ibarra, B., Sgalari, G., MacKintosh, F. C., Carrascosa, J. L., ...
The shell of bacteriophages protects the viral DNA during host-to-host transfer and serves as a high-pressure container storing energy for DNA injection into a host bacterium. Here, we probe the...
Force fluctuations and polymerization dynamics of intracellular microtubules
Brangwynne, Clifford P., MacKintosh, F. C., Weitz, David A.
Microtubules are highly dynamic biopolymer filaments involved in a wide variety of biological processes including cell division, migration, and intracellular transport. Microtubules are very rigid...