Davis, M. J., Hanson, K. A., Clark, F., Fink, J. L., Zhang, F. S., Kasukawa, T., ...
Membrane organization describes the orientation of a protein with respect to the membrane and can be determined by the presence, or absence, and organization within the protein sequence of two...
Patient choice at the point of GP referral: Department of Health (2005)
McDougall, A, McDonald, T, Koduah, H, Round, J, Clark, F, Bourn, J
1 The Department of Health has a Public Service Agreement target to ensure that by the end of 2005 every hospital appointment in the National Health Service in England (the NHS) will be booked for...
Understanding alternative splicing: Towards a cellular code (2005)
Matlin, AJ, Clark, F, Smith, CWJ
In violation of the 'one gene, one polypeptide' rule, alternative splicing allows individual genes to produce multiple protein isoforms - thereby playing a central part in generating complex...
ASD: the Alternative Splicing Database (2004)
Thanaraj, TA, Stamm, S, Clark, F, Riethoven, JJ, Le Texier, V, Muilu, J
Alternative splicing is widespread in mammalian gene expression, and variant splice patterns are often specific to different stages of development, particular tissues or a disease state. There is a...
By spliced alignment of human DNA and transcript sequence data we constructed a data set of transcript-confirmed exons and introns from 2793 genes, 796 of which (28%) were seen to have multiple...
It has been previously observed that the intrinsically weak variant GC donor sites, in order to be recognized by the U2-type spliceosome, possess strong consensus sequences maximized for base pair...
ISIS - The Intron Database. A glimpse of Intron function (1999)
Croft, L., Clark, F., Schandorff, S., Burrage, K., Mattick, J. S.
Thesis (Ph. D.)--University of Leicester, 1988.
Thesis (Ph. D.)--Florida State University.
Spuriously high free thyroxine with the Amerlite MAB FT4 assay.
Lai, L C, Day, J A, Clark, F, Peaston, R T
In the Amerlite MAB FT4 assay, as stated by the manufacturer, FT4 values should be normal in patients with anti-thyroid hormone autoantibodies. The case of a 69 year old woman with a spuriously high...
Natural history of autoimmune thyroiditis.
Tunbridge, W M, Brewis, M, French, J M, Appleton, D, Bird, T, Clark, F, ...
One hundred and sixty-three asymptomatic people with thyroid antibodies or raised serum thyrotrophin (TSH) concentrations, or both, and 209 age-matched and sex-matched controls without either marker...
Shuster, S, Smith, A, Plummer, N, Thody, A, Clark, F
Immunoreactive beta-melanocyte-stimulating hormone (beta-MSH) was measured in the plasma of 19 patients with hypopituitarism and in the cerebrospinal fluid (CSF) of five of these patients. In neither...
Neonatal Hyperthyroidism and Long-acting Thyroid Stimulator Protector
Nutt, J., Clark, F., Welch, R. G., Hall, R.
Neonatal hyperthyroidism has been thought to result from transplacental passage of long-acting thyroid stimulator (L.A.T.S.) from a mother with Graves's disease. A case is presented here in which no...
Electrocardiographic abnormalities associated with raised intracranial pressure.
Jachuck, S J, Ramani, P S, Clark, F, Kalbag, R M
Serial electrocardiographic (E.C.G.) recordings were taken in seven patients suffering from intracranial conditions, for which their intracranial pressure was directly and continuously monitored with...
Spuriously high free thyroxine with the Amerlite MAB FT4 assay.
Lai, L C, Day, J A, Clark, F, Peaston, R T
In the Amerlite MAB FT4 assay, as stated by the manufacturer, FT4 values should be normal in patients with anti-thyroid hormone autoantibodies. The case of a 69 year old woman with a spuriously high...
Natural history of autoimmune thyroiditis.
Tunbridge, W M, Brewis, M, French, J M, Appleton, D, Bird, T, Clark, F, ...
One hundred and sixty-three asymptomatic people with thyroid antibodies or raised serum thyrotrophin (TSH) concentrations, or both, and 209 age-matched and sex-matched controls without either marker...
Shuster, S, Smith, A, Plummer, N, Thody, A, Clark, F
Immunoreactive beta-melanocyte-stimulating hormone (beta-MSH) was measured in the plasma of 19 patients with hypopituitarism and in the cerebrospinal fluid (CSF) of five of these patients. In neither...
Neonatal Hyperthyroidism and Long-acting Thyroid Stimulator Protector
Nutt, J., Clark, F., Welch, R. G., Hall, R.
Neonatal hyperthyroidism has been thought to result from transplacental passage of long-acting thyroid stimulator (L.A.T.S.) from a mother with Graves's disease. A case is presented here in which no...
Electrocardiographic abnormalities associated with raised intracranial pressure.
Jachuck, S J, Ramani, P S, Clark, F, Kalbag, R M
Serial electrocardiographic (E.C.G.) recordings were taken in seven patients suffering from intracranial conditions, for which their intracranial pressure was directly and continuously monitored with...
Defective regulation of the immune response to tetanus toxoid in Hashimoto's disease.
Fawcett, J, Hutton, C, Mclachlan, S M, Clark, F, Rees Smith, B
The humoral immune response to tetanus toxoid has been studied in patients with Hashimoto's disease. Although the magnitude of the response was similar to that observed in normal subjects, the...
McGregor, A, McLachlan, S, Clark, F, Smith, B R, Hall, R
Peripheral blood lymphocytes from patients with Hashimoto's thyroiditis have been cultured for 2--3 weeks in Marbrook flasks. During this period, readily detectable amounts of thyroglobulin and...
Cytokines, thyroid autoantibody synthesis and thyroid cell survival in culture.
McLachlan, S M, Taverne, J, Atherton, M C, Cooke, A, Middleton, S, Pegg, C A, ...
In autoimmune thyroid disease lymphoid cells infiltrating the thyroid gland occur in conspicuous aggregates or as a diffusely distributed population invading the thyroid follicles. Consequently...
Thyroid peroxidase and the induction of autoimmune thyroid disease.
McLachlan, S M, Atherton, M C, Nakajima, Y, Napier, J, Jordan, R K, Clark, F, ...
Animal models of autoimmune thyroid disease are associated with thyroglobulin (Tg) as autoantigen whereas in man the autoimmune response to microsomal antigen/thyroid peroxidase (TPO) appears to play...
Serial studies on the affinity and heterogeneity of human autoantibodies to thyroglobulin.
Devey, M E, Bleasdale-Barr, K M, McLachlan, S M, Bradbury, J, Clark, F, Young, E T
The functional affinity and heterogeneity of autoantibodies to thyroglobulin (Tg) were measured by an IgG subclass-specific solid-phase competition ELISA in patients with autoimmune thyroid disease....
McLachlan, S M, Pegg, C A, Atherton, M C, Middleton, S L, Dickinson, A, Clark, F, ...
Lymphocytes isolated from Graves' and Hashimoto thyroid tissue by enzymatic (dispase) digestion or mechanical disaggregation were markedly different in terms of their ability to synthesize thyroid...
T cell regulation of thyroglobulin autoantibody IgG subclasses in Hashimoto's thyroiditis.
Forouhi, N G, McLachlan, S M, Middleton, S L, Atherton, M C, Baylis, P, Clark, F, ...
Microsomal and thyroglobulin (Tg) antibodies in patients with autoimmune thyroid disease are usually predominantly of subclasses IgG1 and/or IgG4 and the distribution pattern is characteristic for...
Functional analysis of T and B cells from blood and thyroid tissue in Hashimoto's disease.
McLachlan, S M, Proud, G, Pegg, C A, Clark, F, Rees Smith, B
B lymphocytes from Hashimoto blood and thyroid tissue have been cultured with autologous T cells from thyroid/blood to assess their ability to synthesise IgG and thyroid autoantibody. Thyroid B cells...
Jansson, R, Thompson, P M, Clark, F, McLachlan, S M
The potential role of thyroid microsomal (Mic) antibodies in the development of postpartum hypothyroidism was investigated in 34 euthyroid women, whose sera were found to contain Mic antibodies in...
Graves' disease and Down's syndrome
McCulloch, A J, Clark, F, Steele, N R
A case is described of severe thyrotoxicosis occurring in a patient with Down's syndrome, in which behavioural disturbance was a marked but reversible phenomenon. In addition, we report that...
Winocour, P. H., Masud, T., Clark, F., Cooper, B. G., Laker, M. F., Alberti, K. G.
Lipid metabolism was evaluated during management of phaeochromocytoma in a 41 year old non-obese post-menopausal women with familial combined hyperlipidaemia. The main effect of the excess...
Polycystic ovarian syndrome in identical twins.
Two 21-year-old female twins are described. They presented simultaneously with hirsutism and oligomenorrhoea. Investigation showed they had polycystic ovaries, they were identical and were not cases...
A brainstem syndrome associatedxb with Mycoplasma pneumoniae infection—A report of two cases*
Jachuck, S. J., Gardner-Thorpe, C., Clark, F., Foster, J. B.
Two patients with a serologically-proved infection with Mycoplasma pneumoniae (MP) developed cranial nerve pareses which cleared spontaneously within 1 month of the onset. The sixth and seventh...
Ophthalmic Graves' disease in monozygotic twins
Thornham, J. R., Nutt, J. E., Clark, F.
A pair of identical female twins with ophthalmic Graves' disease is described. Monozygosity was confirmed by analysis of blood groups and red cell isoenzymes. Thyroid status was assessed by standard...
Oxyphenbutazone-induced goitre.
Lane, R. J., Clark, F., McCollum, J. K.
A woman who had taken oxyphenbutazone for 4 years because of back pain presented with goitre and hypothyroidism. This was shown to be due to an organification defect, caused or aggravated by...
Practolol-induced autoantibodies and their relation to oculo-cutaneous complications.
Jachuck, S. J., Stephenson, J., Bird, T., Jackson, F. S., Clark, F.
Tissue auto-antibodies were investigated in fifty-one patients (twenty-five female, twenty-six male) receiving practolol for ischaemic heart disease or dysrhythmias and compared with those found in...